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The Effects of Exercise and Osteocal...

Rentz, Jesse Lee.

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The Effects of Exercise and Osteocalcin on Metabolism, Behaviour and Cognition of Female Mice Fed Either a Low-Fat or High-Fat Diet.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The Effects of Exercise and Osteocalcin on Metabolism, Behaviour and Cognition of Female Mice Fed Either a Low-Fat or High-Fat Diet./
Author:	Rentz, Jesse Lee.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2020,
Description:	104 p.
Notes:	Source: Masters Abstracts International, Volume: 82-06.
Contained By:	Masters Abstracts International82-06.
Subject:	Pharmacology. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28150446
ISBN:	9798698555162

The Effects of Exercise and Osteocalcin on Metabolism, Behaviour and Cognition of Female Mice Fed Either a Low-Fat or High-Fat Diet.
Rentz, Jesse Lee.

The Effects of Exercise and Osteocalcin on Metabolism, Behaviour and Cognition of Female Mice Fed Either a Low-Fat or High-Fat Diet. - Ann Arbor : ProQuest Dissertations & Theses, 2020 - 104 p.

Source: Masters Abstracts International, Volume: 82-06.

Thesis (M.Sc.)--University of Toronto (Canada), 2020.

This item must not be sold to any third party vendors.

Osteoblast-derived osteocalcin (Ocn) is implicated in the endocrine actions of the skeleton in modulating cognition, mood and energy homeostasis. Here we compared the effects of daily treadmill exercise, 30 ng/g/day Ocn administration, or the combination of both in female C57Bl/6J mice fed either a low-fat or high-fat diet. Weight gain from high-fat diet was decreased and glucose tolerance improved by exercise with or without Ocn but not by Ocn alone. Exercise, osteocalcin and their combination alleviated the depressive-like but not anxiety-like behaviours induced by a high-fat diet. Cognitive deficits induced by high-fat diet were reversed by exercise or Ocn, with combined treatment having the greatest effect. Under normal metabolic conditions, neither exercise nor Ocn altered behavioural responses. Together, these results suggest that exercise is more effective in improving metabolism while osteocalcin or exercise are effective in treating cognitive deficits and depressive-like behaviours caused by high-fat diet.

ISBN: 9798698555162Subjects--Topical Terms:

634543
Pharmacology.
Subjects--Index Terms:

Behaviour

The Effects of Exercise and Osteocalcin on Metabolism, Behaviour and Cognition of Female Mice Fed Either a Low-Fat or High-Fat Diet.
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