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Decoding Host-Pathogen Interaction N...
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Delgado-Moshkina, Natasha.
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Decoding Host-Pathogen Interaction Networks to Understand Viral Life Cycles and Host Response.
紀錄類型:
書目-電子資源 : Monograph/item
正題名/作者:
Decoding Host-Pathogen Interaction Networks to Understand Viral Life Cycles and Host Response./
作者:
Delgado-Moshkina, Natasha.
出版者:
Ann Arbor : ProQuest Dissertations & Theses, : 2020,
面頁冊數:
199 p.
附註:
Source: Dissertations Abstracts International, Volume: 83-01, Section: B.
Contained By:
Dissertations Abstracts International83-01B.
標題:
Biology. -
電子資源:
https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28547433
ISBN:
9798516930706
Decoding Host-Pathogen Interaction Networks to Understand Viral Life Cycles and Host Response.
Delgado-Moshkina, Natasha.
Decoding Host-Pathogen Interaction Networks to Understand Viral Life Cycles and Host Response.
- Ann Arbor : ProQuest Dissertations & Theses, 2020 - 199 p.
Source: Dissertations Abstracts International, Volume: 83-01, Section: B.
Thesis (Ph.D.)--Icahn School of Medicine at Mount Sinai, 2020.
This item must not be sold to any third party vendors.
The human body is a complex 'megalopolis' of organs, tissues, cells, and molecules thatgovern harmonious homeostatic flow that functions as a flexible system capable to adjust tofluctuations caused by external stressors. On the other hand, a seemingly simple viral particle ispowerful enough to invade a host and cause the butterfly effect ultimately altering nearly everyhost's cell. Viral perturbations in cellular homeostasis can result in misbalance of an entireorganism and lead to a diseased state. This work is dedicated to investigation of host-pathogenrelationships in an effort to understand how viral invasion manipulates the host immuneresponse and causes diseases. Specifically, we address pathogenicity of influenza virus and applyinfection as a tool for identifying genetic components that regulate inflammatory response inhuman cells. Our goal is to study mechanisms that underlie the innate immune response byinterrogating i) virus-host protein-protein interactions, ii) changes in the gene expression profileinduced by influenza virus infection, and iii) new candidate genes mutated in diseases.
ISBN: 9798516930706Subjects--Topical Terms:
522710
Biology.
Subjects--Index Terms:
Biology
Decoding Host-Pathogen Interaction Networks to Understand Viral Life Cycles and Host Response.
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