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Estimation of Ingested Nano-Titanium...

Putra, Christianto.

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Estimation of Ingested Nano-Titanium Dioxide among Healthy Adults and Its Association with Intestinal Permeability and Inflammation.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Estimation of Ingested Nano-Titanium Dioxide among Healthy Adults and Its Association with Intestinal Permeability and Inflammation./
作者:	Putra, Christianto.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2021,
面頁冊數:	143 p.
附註:	Source: Dissertations Abstracts International, Volume: 82-12, Section: B.
Contained By:	Dissertations Abstracts International82-12B.
標題:	Pharmaceutical sciences. -
電子資源:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28415785
ISBN:	9798505599891

Estimation of Ingested Nano-Titanium Dioxide among Healthy Adults and Its Association with Intestinal Permeability and Inflammation.
Putra, Christianto.

Estimation of Ingested Nano-Titanium Dioxide among Healthy Adults and Its Association with Intestinal Permeability and Inflammation. - Ann Arbor : ProQuest Dissertations & Theses, 2021 - 143 p.

Source: Dissertations Abstracts International, Volume: 82-12, Section: B.

Thesis (Ph.D.)--University of Massachusetts Lowell, 2021.

This item must not be sold to any third party vendors.

Background: Titanium dioxide (TiO2/E171) is used in food primarily as a whitening agent. Over 99% of ingested TiO2 passes to the gastrointestinal (GI) tract. At present, little is known regarding TiO2 intake in the U.S. and how exposure relates to human gut health.Objective: To estimate usual TiO2 intake among healthy adults in the U.S. and to investigate the associations between TiO2 intake with gut permeability and inflammation.Methods: Healthy participants, aged 18-30y, were recruited in two phases from Lowell, MA. Phase 1: Dietary TiO2 was estimated from 3, 24-h dietary recalls (24hDR) and stool TiO2 was measured from 3 stool samples collected the same day of each recall, across a total of 14 days. Phase 2: usual 6-mo TiO2 intake was estimated from a tailored food frequency questionnaire (FFQ) and stool TiO2 was collected once a month for 3-mo. TiO2 concentration in food and stool samples was measured using ICP-MS. Differences in intestinal permeability (alpha-1-antitrypsin, A1AT) and inflammation (calprotectin and lactoferrin) were tested between high TiO2 (HT) and low TiO2 (LT) exposure groups, assessed by stool TiO2.Results: TiO2 food content varies widely by brand. Mean TiO2 intake was lower estimated from 3, 24hDR (0.19±0.31 mg/Kgbw/d) compared to FFQ (0.30±0.21 mg/Kgbw/d). Mean TiO2 in phase 1 and phase 2 dry stool was 0.402±0.486 μg/mg and 0.290±0.485 μg/mg, respectively. Estimated TiO2 intake was not predictive of stool TiO2, in either phase 1 (β: 0.056±0.125, P=0.66) nor phase 2 (β: -0.212±0.238, P=0.38). Higher intestinal permeability was observed in the HT group (A1AT: 17.57±10.00 μg/g) compared to the LT group (8.01±5.10 μg/g, P<0.05). Higher stool calprotectin was observed in the HT group (52.71±52.84 μg/g) compared to the LT group (50.23±61.28 μg/g, P=0.06). Participants with HT were twice as likely to have lactoferrin above the median of 0.45 μg/g compared to individuals in the LT group (OR=2.06; P=0.12).Conclusion: To our knowledge, this is the first study to assess dietary TiO2 using validated dietary methods in the U.S. and stool excretion as a marker of intake. Data from the current study demonstrates a wide distribution of TiO2 intake 0.00-1.53 mg/Kgbw/d. Due to high exposure in some populations, there is a need for a comprehensive engineered nanoparticle database to support future research. Material characterization, and careful evaluation for the widespread use of E171 and its chronic effect on human health, especially among individuals prone to gastrointestinal ailments, should be considered.

ISBN: 9798505599891Subjects--Topical Terms:

3173021
Pharmaceutical sciences.
Subjects--Index Terms:

Dietary recall

Estimation of Ingested Nano-Titanium Dioxide among Healthy Adults and Its Association with Intestinal Permeability and Inflammation.
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500 $a Source: Dissertations Abstracts International, Volume: 82-12, Section: B.
500 $a Advisor: Mangano, Kelsey M.
502 $a Thesis (Ph.D.)--University of Massachusetts Lowell, 2021.
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520 $a Background: Titanium dioxide (TiO2/E171) is used in food primarily as a whitening agent. Over 99% of ingested TiO2 passes to the gastrointestinal (GI) tract. At present, little is known regarding TiO2 intake in the U.S. and how exposure relates to human gut health.Objective: To estimate usual TiO2 intake among healthy adults in the U.S. and to investigate the associations between TiO2 intake with gut permeability and inflammation.Methods: Healthy participants, aged 18-30y, were recruited in two phases from Lowell, MA. Phase 1: Dietary TiO2 was estimated from 3, 24-h dietary recalls (24hDR) and stool TiO2 was measured from 3 stool samples collected the same day of each recall, across a total of 14 days. Phase 2: usual 6-mo TiO2 intake was estimated from a tailored food frequency questionnaire (FFQ) and stool TiO2 was collected once a month for 3-mo. TiO2 concentration in food and stool samples was measured using ICP-MS. Differences in intestinal permeability (alpha-1-antitrypsin, A1AT) and inflammation (calprotectin and lactoferrin) were tested between high TiO2 (HT) and low TiO2 (LT) exposure groups, assessed by stool TiO2.Results: TiO2 food content varies widely by brand. Mean TiO2 intake was lower estimated from 3, 24hDR (0.19±0.31 mg/Kgbw/d) compared to FFQ (0.30±0.21 mg/Kgbw/d). Mean TiO2 in phase 1 and phase 2 dry stool was 0.402±0.486 μg/mg and 0.290±0.485 μg/mg, respectively. Estimated TiO2 intake was not predictive of stool TiO2, in either phase 1 (β: 0.056±0.125, P=0.66) nor phase 2 (β: -0.212±0.238, P=0.38). Higher intestinal permeability was observed in the HT group (A1AT: 17.57±10.00 μg/g) compared to the LT group (8.01±5.10 μg/g, P<0.05). Higher stool calprotectin was observed in the HT group (52.71±52.84 μg/g) compared to the LT group (50.23±61.28 μg/g, P=0.06). Participants with HT were twice as likely to have lactoferrin above the median of 0.45 μg/g compared to individuals in the LT group (OR=2.06; P=0.12).Conclusion: To our knowledge, this is the first study to assess dietary TiO2 using validated dietary methods in the U.S. and stool excretion as a marker of intake. Data from the current study demonstrates a wide distribution of TiO2 intake 0.00-1.53 mg/Kgbw/d. Due to high exposure in some populations, there is a need for a comprehensive engineered nanoparticle database to support future research. Material characterization, and careful evaluation for the widespread use of E171 and its chronic effect on human health, especially among individuals prone to gastrointestinal ailments, should be considered.
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