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Mechanisms of Chemotropism in Fungi:...

Clark-Cotton, Manuella Rossette.

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Mechanisms of Chemotropism in Fungi: Saccharomyces cerevisiae as a Model.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Mechanisms of Chemotropism in Fungi: Saccharomyces cerevisiae as a Model./
Author:	Clark-Cotton, Manuella Rossette.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2021,
Description:	115 p.
Notes:	Source: Dissertations Abstracts International, Volume: 82-12, Section: B.
Contained By:	Dissertations Abstracts International82-12B.
Subject:	Cellular biology. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28320831
ISBN:	9798738637292

Mechanisms of Chemotropism in Fungi: Saccharomyces cerevisiae as a Model.
Clark-Cotton, Manuella Rossette.

Mechanisms of Chemotropism in Fungi: Saccharomyces cerevisiae as a Model. - Ann Arbor : ProQuest Dissertations & Theses, 2021 - 115 p.

Source: Dissertations Abstracts International, Volume: 82-12, Section: B.

Thesis (Ph.D.)--Duke University, 2021.

This item must not be sold to any third party vendors.

Budding yeast decode pheromone gradients to locate mating partners, providing a model of chemotropism in fungi. How yeast polarize toward a single partner in crowded environments is unclear. Initially, cells often polarize in unproductive directions, but then they relocate the polarity site until two partners' polarity sites align, whereupon the cells "commit" to each other by stabilizing polarity to promote fusion. Using live-cell fluorescence microscopy, computational modeling, and quantitative autocorrelation analyses, I address the role of the early mobile polarity sites, finding that commitment by either partner failed if just one partner was defective in generating, orienting, or stabilizing its mobile polarity sites. Mobile polarity sites were enriched for pheromone receptors and G proteins, suggesting that such sites engage in an exploratory search of the local pheromone landscape, stabilizing only when they detect elevated pheromone levels. Mobile polarity sites were also enriched for pheromone secretion factors, and simulations suggest that only focal secretion at polarity sites would produce high pheromone concentrations at the partner's polarity site, triggering commitment.

ISBN: 9798738637292Subjects--Topical Terms:

3172791
Cellular biology.
Subjects--Index Terms:

Cell polarity

Mechanisms of Chemotropism in Fungi: Saccharomyces cerevisiae as a Model.
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245 1 0 $a Mechanisms of Chemotropism in Fungi: Saccharomyces cerevisiae as a Model.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2021
300 $a 115 p.
500 $a Source: Dissertations Abstracts International, Volume: 82-12, Section: B.
500 $a Advisor: Lew, Daniel J.
502 $a Thesis (Ph.D.)--Duke University, 2021.
506 $a This item must not be sold to any third party vendors.
520 $a Budding yeast decode pheromone gradients to locate mating partners, providing a model of chemotropism in fungi. How yeast polarize toward a single partner in crowded environments is unclear. Initially, cells often polarize in unproductive directions, but then they relocate the polarity site until two partners' polarity sites align, whereupon the cells "commit" to each other by stabilizing polarity to promote fusion. Using live-cell fluorescence microscopy, computational modeling, and quantitative autocorrelation analyses, I address the role of the early mobile polarity sites, finding that commitment by either partner failed if just one partner was defective in generating, orienting, or stabilizing its mobile polarity sites. Mobile polarity sites were enriched for pheromone receptors and G proteins, suggesting that such sites engage in an exploratory search of the local pheromone landscape, stabilizing only when they detect elevated pheromone levels. Mobile polarity sites were also enriched for pheromone secretion factors, and simulations suggest that only focal secretion at polarity sites would produce high pheromone concentrations at the partner's polarity site, triggering commitment.
590 $a School code: 0066.
650 4 $a Cellular biology. $3 3172791
650 4 $a Microbiology. $3 536250
650 4 $a Biology. $3 522710
653 $a Cell polarity
653 $a Chemotaxis
653 $a Chemotropism
653 $a Directional sensing
653 $a Gradient sensing
653 $a Gradient tracking
690 $a 0379
690 $a 0410
690 $a 0306
710 2 $a Duke University. $b Cell Biology. $3 3286054
773 0 $t Dissertations Abstracts International $g 82-12B.
790 $a 0066
791 $a Ph.D.
792 $a 2021
793 $a English
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28320831