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Vascular Hemodynamics and Blood Pres...

Ballenger, Brantley.

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Vascular Hemodynamics and Blood Pressure Differences Between Young and Older Women.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Vascular Hemodynamics and Blood Pressure Differences Between Young and Older Women./
Author:	Ballenger, Brantley.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2020,
Description:	25 p.
Notes:	Source: Masters Abstracts International, Volume: 82-04.
Contained By:	Masters Abstracts International82-04.
Subject:	Kinesiology. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28029867
ISBN:	9798672165936

Vascular Hemodynamics and Blood Pressure Differences Between Young and Older Women.
Ballenger, Brantley.

Vascular Hemodynamics and Blood Pressure Differences Between Young and Older Women. - Ann Arbor : ProQuest Dissertations & Theses, 2020 - 25 p.

Source: Masters Abstracts International, Volume: 82-04.

Thesis (M.S.)--The University of Alabama at Birmingham, 2020.

This item must not be sold to any third party vendors.

Background: CVD is one of the main causes of death in the United States, and hypertension is a primary risk factor of this disease. Therefore, the primary causes of hypertension need to be identified so they may be addressed for treatment. Hypertension is known to be brought on by factors such as obesity, smoking, and age, but more knowledge is needed to address why otherwise healthy individuals suffer from the condition. Additionally, knowledge is needed on identifiable predictive measures which have association with hypertension to decrease the progression of CVD.Purpose: Compare blood pressure with hemodynamic values and identify factors that predict the development of hypertension and other cardiovascular diseases between a cohort of healthy normotensive younger and older women.Methods: Participants were 49 young (Age: 33.8 ± 5.9) and 103 old (Age: 65.8 ± 4) who were non-hypertensive, had no previous history of heart disease or type 2 diabetes, BMI less than 30 kg/m2, normal electrocardiography (EKG) response at rest and during exercise, nonsmokers, and no use of medications known to affect cardiovascular or metabolic function. Body composition measured by dual-energy X-ray absorptiometry (DEXA). Hemodynamic values measured by non-invasive pulse wave velocity through radial artery tonometry. Markers of inflammation measured through blood sample analysis.Results: Significant differences exist between young and old groups in %fat (P<0.0001), systolic blood pressure (P=0.001), large artery elasticity (P=0.005), small artery elasticity (P<0.0001), systemic vascular resistance (P=0.004), total vascular impedance (P<0.0001), estimated cardiac output (P<0.0001), and TNF-⍺ (P<0.0001). ANCOVA showed small artery elasticity (P<0.0001) and TNF-⍺ (P=0.041) to both be significant with SBP when age was not.Discussion: These data demonstrate that blood pressure and vascular hemodynamic measures differ significantly between young and old women independent of body composition. Furthermore, these differences may be explained by the inflammation marker TNF-⍺ and/or small artery elasticity.

ISBN: 9798672165936Subjects--Topical Terms:

517627
Kinesiology.
Subjects--Index Terms:

Arterial elasticity

Vascular Hemodynamics and Blood Pressure Differences Between Young and Older Women.
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260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2020
300 $a 25 p.
500 $a Source: Masters Abstracts International, Volume: 82-04.
500 $a Advisor: Fisher, Gordon.
502 $a Thesis (M.S.)--The University of Alabama at Birmingham, 2020.
506 $a This item must not be sold to any third party vendors.
520 $a Background: CVD is one of the main causes of death in the United States, and hypertension is a primary risk factor of this disease. Therefore, the primary causes of hypertension need to be identified so they may be addressed for treatment. Hypertension is known to be brought on by factors such as obesity, smoking, and age, but more knowledge is needed to address why otherwise healthy individuals suffer from the condition. Additionally, knowledge is needed on identifiable predictive measures which have association with hypertension to decrease the progression of CVD.Purpose: Compare blood pressure with hemodynamic values and identify factors that predict the development of hypertension and other cardiovascular diseases between a cohort of healthy normotensive younger and older women.Methods: Participants were 49 young (Age: 33.8 ± 5.9) and 103 old (Age: 65.8 ± 4) who were non-hypertensive, had no previous history of heart disease or type 2 diabetes, BMI less than 30 kg/m2, normal electrocardiography (EKG) response at rest and during exercise, nonsmokers, and no use of medications known to affect cardiovascular or metabolic function. Body composition measured by dual-energy X-ray absorptiometry (DEXA). Hemodynamic values measured by non-invasive pulse wave velocity through radial artery tonometry. Markers of inflammation measured through blood sample analysis.Results: Significant differences exist between young and old groups in %fat (P<0.0001), systolic blood pressure (P=0.001), large artery elasticity (P=0.005), small artery elasticity (P<0.0001), systemic vascular resistance (P=0.004), total vascular impedance (P<0.0001), estimated cardiac output (P<0.0001), and TNF-⍺ (P<0.0001). ANCOVA showed small artery elasticity (P<0.0001) and TNF-⍺ (P=0.041) to both be significant with SBP when age was not.Discussion: These data demonstrate that blood pressure and vascular hemodynamic measures differ significantly between young and old women independent of body composition. Furthermore, these differences may be explained by the inflammation marker TNF-⍺ and/or small artery elasticity.
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653 $a Cardiometabolic health
653 $a Inflammation
653 $a Vascular hemodynamics
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653 $a Risk factor
653 $a Hypertension
653 $a Obesity
653 $a Smoking
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653 $a Artery elasticity
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