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Dominant Targets of the COVID-19 Ada...

Brown, Matthew.

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Dominant Targets of the COVID-19 Adaptive Immune Response.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Dominant Targets of the COVID-19 Adaptive Immune Response./
作者:	Brown, Matthew.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2021,
面頁冊數:	39 p.
附註:	Source: Masters Abstracts International, Volume: 83-01.
Contained By:	Masters Abstracts International83-01.
標題:	Immunology. -
電子資源:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28543347
ISBN:	9798516079498

Dominant Targets of the COVID-19 Adaptive Immune Response.
Brown, Matthew.

Dominant Targets of the COVID-19 Adaptive Immune Response. - Ann Arbor : ProQuest Dissertations & Theses, 2021 - 39 p.

Source: Masters Abstracts International, Volume: 83-01.

Thesis (M.S.)--Icahn School of Medicine at Mount Sinai, 2021.

This item must not be sold to any third party vendors.

The COVID-19 pandemic is a public health crisis that has unfortunately taken the lives of millions of individuals worldwide. However, the precise epitope targets and kinetics of the adaptive immune response are still poorly understood. We hypothesized that within a heterogenous adaptive immune response, there exist dominant epitope regions essential for recognition of SARS-CoV-2. We were able to identify in silico dominant T cell epitope regions within the SARS-CoV-2 proteome capable of binding HLA alleles from a broad array of ethnicities and experimentally verify the predicted epitope regions specific to the SARS-CoV-2 B and T cell response. Additionally, we were able to deconvolute a number of immunodominant SARS-CoV-2 T cell epitopes and also identify human/SARS-CoV-2 cross-reactive epitopes potentially involved in autoreactivity. Finally, we evaluated the kinetics of the vaccine-induced B and T cell response. This information is critical to identifying correlates of protection and targets of next-generation coronavirus vaccines.

ISBN: 9798516079498Subjects--Topical Terms:

611031
Immunology.
Subjects--Index Terms:

SARS-CoV-2 B

Dominant Targets of the COVID-19 Adaptive Immune Response.
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520 $a The COVID-19 pandemic is a public health crisis that has unfortunately taken the lives of millions of individuals worldwide. However, the precise epitope targets and kinetics of the adaptive immune response are still poorly understood. We hypothesized that within a heterogenous adaptive immune response, there exist dominant epitope regions essential for recognition of SARS-CoV-2. We were able to identify in silico dominant T cell epitope regions within the SARS-CoV-2 proteome capable of binding HLA alleles from a broad array of ethnicities and experimentally verify the predicted epitope regions specific to the SARS-CoV-2 B and T cell response. Additionally, we were able to deconvolute a number of immunodominant SARS-CoV-2 T cell epitopes and also identify human/SARS-CoV-2 cross-reactive epitopes potentially involved in autoreactivity. Finally, we evaluated the kinetics of the vaccine-induced B and T cell response. This information is critical to identifying correlates of protection and targets of next-generation coronavirus vaccines.
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