東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Evaluations of Diagnostic Tests for ...

Watthanaworawit, Wanitda.

FindBook

Google Book

Amazon

博客來

Evaluations of Diagnostic Tests for Undifferentiated Febrile Illness on the Thailand-Myanmar (Burma) Border.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Evaluations of Diagnostic Tests for Undifferentiated Febrile Illness on the Thailand-Myanmar (Burma) Border./
作者:	Watthanaworawit, Wanitda.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2018,
面頁冊數:	369 p.
附註:	Source: Dissertations Abstracts International, Volume: 80-10, Section: B.
Contained By:	Dissertations Abstracts International80-10B.
標題:	Medicine. -
電子資源:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=13872617
ISBN:	9781658459525

Evaluations of Diagnostic Tests for Undifferentiated Febrile Illness on the Thailand-Myanmar (Burma) Border.
Watthanaworawit, Wanitda.

Evaluations of Diagnostic Tests for Undifferentiated Febrile Illness on the Thailand-Myanmar (Burma) Border. - Ann Arbor : ProQuest Dissertations & Theses, 2018 - 369 p.

Source: Dissertations Abstracts International, Volume: 80-10, Section: B.

Thesis (Ph.D.)--Open University (United Kingdom), 2018.

This item must not be sold to any third party vendors.

Dengue, leptospirosis and rickettsial infections are the most common non-malaria causes of acute undifferentiated febrile illness in Southeast Asia. Current diagnostic tests are inadequate for clinical use.We conducted a two year prospective fever study in three outpatient clinics on the Thailand-Myanmar border, recruiting patients aged at least five years with acute undifferentiated febrile illness. The study was divided into two parts: non-malaria and malaria patients. Specimens were tested to determine the causes of fever and to evaluate the clinical diagnostic accuracy of the tests for early diagnosis of dengue, leptospirosis and rickettsial infections.A total of 1,029 febrile patients were recruited: 908 non-malaria and 121 malaria patients. A laboratory confirmed diagnosis was made in 34.5% of non-malaria patients, of which 15.9% were dengue, 6.0% leptospirosis, 6.0% murine typhus, and 3.2% scrub typhus. Co-infection was found in 1.7% with mostly leptospirosis and scrub typhus (1.5%). In malaria patients, co-infection was found in 8.3% in most cases with scrub typhus (7.4%).An immunochromatographic test (ICT) (Non-structural protein 1 [NS1] and Immunoglobulin M [IgM]/Immunoglobulin G [IgG] detection) and real-time reverse transcriptase polymerase chain reaction (rRT-PCR) were evaluated for dengue diagnosis using acute plasma specimens. Sensitivities of the ICT and rRT-PCR were 86.1% (95% confidence interval [CI] 79.4-91.3) and 97.2% (95% CI 93.0-99.2), and specificities were94.9% (95% CI 93.0-96.4) and 99.1% (95% CI 98.1-99.7), respectively compared against IgM/IgG enzyme-linked immunosorbent assay (ELISA). Combining rRT-PCR with ICT improved the sensitivity of the diagnostic process to 98.6% (95% CI 95.1-99.8).

ISBN: 9781658459525Subjects--Topical Terms:

641104
Medicine.
Subjects--Index Terms:

Dengue

Evaluations of Diagnostic Tests for Undifferentiated Febrile Illness on the Thailand-Myanmar (Burma) Border.
LDR:02924nmm a2200373 4500 001 2281369
005 20210920102946.5
008 220723s2018 ||||||||||||||||| ||eng d
020 $a 9781658459525
035 $a (MiAaPQ)AAI13872617
035 $a (MiAaPQ)Open_Univ_UK53630
035 $a AAI13872617
040 $a MiAaPQ $c MiAaPQ
100 1 $a Watthanaworawit, Wanitda. $3 3559957
245 1 0 $a Evaluations of Diagnostic Tests for Undifferentiated Febrile Illness on the Thailand-Myanmar (Burma) Border.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2018
300 $a 369 p.
500 $a Source: Dissertations Abstracts International, Volume: 80-10, Section: B.
502 $a Thesis (Ph.D.)--Open University (United Kingdom), 2018.
506 $a This item must not be sold to any third party vendors.
520 $a Dengue, leptospirosis and rickettsial infections are the most common non-malaria causes of acute undifferentiated febrile illness in Southeast Asia. Current diagnostic tests are inadequate for clinical use.We conducted a two year prospective fever study in three outpatient clinics on the Thailand-Myanmar border, recruiting patients aged at least five years with acute undifferentiated febrile illness. The study was divided into two parts: non-malaria and malaria patients. Specimens were tested to determine the causes of fever and to evaluate the clinical diagnostic accuracy of the tests for early diagnosis of dengue, leptospirosis and rickettsial infections.A total of 1,029 febrile patients were recruited: 908 non-malaria and 121 malaria patients. A laboratory confirmed diagnosis was made in 34.5% of non-malaria patients, of which 15.9% were dengue, 6.0% leptospirosis, 6.0% murine typhus, and 3.2% scrub typhus. Co-infection was found in 1.7% with mostly leptospirosis and scrub typhus (1.5%). In malaria patients, co-infection was found in 8.3% in most cases with scrub typhus (7.4%).An immunochromatographic test (ICT) (Non-structural protein 1 [NS1] and Immunoglobulin M [IgM]/Immunoglobulin G [IgG] detection) and real-time reverse transcriptase polymerase chain reaction (rRT-PCR) were evaluated for dengue diagnosis using acute plasma specimens. Sensitivities of the ICT and rRT-PCR were 86.1% (95% confidence interval [CI] 79.4-91.3) and 97.2% (95% CI 93.0-99.2), and specificities were94.9% (95% CI 93.0-96.4) and 99.1% (95% CI 98.1-99.7), respectively compared against IgM/IgG enzyme-linked immunosorbent assay (ELISA). Combining rRT-PCR with ICT improved the sensitivity of the diagnostic process to 98.6% (95% CI 95.1-99.8).
590 $a School code: 0949.
650 4 $a Medicine. $3 641104
650 4 $a Health sciences. $3 3168359
650 4 $a Virology. $3 642304
650 4 $a Infections. $3 1621997
650 4 $a Infectious diseases. $3 2179310
650 4 $a Refugees. $3 728185
650 4 $a Accuracy. $3 3559958
650 4 $a Epidemiology. $3 568544
650 4 $a Demographics. $3 3540640
650 4 $a Mortality. $3 533218
650 4 $a Diagnostic tests. $3 3559959
650 4 $a Data analysis. $2 bisacsh $3 3515250
650 4 $a Polymerase chain reaction. $3 518049
650 4 $a Leptospirosis. $3 2131539
650 4 $a Proteins. $3 558769
650 4 $a Patients. $3 1961957
650 4 $a Encephalitis. $3 744141
650 4 $a Blood tests. $3 3559960
650 4 $a Bacterial infections. $3 3559961
650 4 $a Deoxyribonucleic acid--DNA. $3 3546879
650 4 $a Viruses. $3 571474
650 4 $a Illnesses. $3 3559962
650 4 $a Immunoglobulins. $3 898739
650 4 $a Antigens. $3 700737
650 4 $a Dengue fever. $3 3559963
650 4 $a Enzymes. $3 520899
650 4 $a Tropical diseases. $3 3559964
653 $a Dengue
653 $a Leptospirosis
653 $a Rickettsial
653 $a Tropical medicine
690 $a 0720
690 $a 0566
690 $a 0564
690 $a 0766
710 2 $a Open University (United Kingdom). $3 3427325
773 0 $t Dissertations Abstracts International $g 80-10B.
790 $a 0949
791 $a Ph.D.
792 $a 2018
793 $a English
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=13872617