語系:
繁體中文
English
說明(常見問題)
回圖書館首頁
手機版館藏查詢
登入
回首頁
切換:
標籤
|
MARC模式
|
ISBD
Advanced Graphene Nanostructures for...
~
Terse, Trupti Madhukar.
FindBook
Google Book
Amazon
博客來
Advanced Graphene Nanostructures for Biosensing Applications.
紀錄類型:
書目-電子資源 : Monograph/item
正題名/作者:
Advanced Graphene Nanostructures for Biosensing Applications./
作者:
Terse, Trupti Madhukar.
出版者:
Ann Arbor : ProQuest Dissertations & Theses, : 2016,
面頁冊數:
152 p.
附註:
Source: Dissertations Abstracts International, Volume: 78-09, Section: B.
Contained By:
Dissertations Abstracts International78-09B.
標題:
Analytical chemistry. -
電子資源:
https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10245752
ISBN:
9781369656848
Advanced Graphene Nanostructures for Biosensing Applications.
Terse, Trupti Madhukar.
Advanced Graphene Nanostructures for Biosensing Applications.
- Ann Arbor : ProQuest Dissertations & Theses, 2016 - 152 p.
Source: Dissertations Abstracts International, Volume: 78-09, Section: B.
Thesis (Ph.D.)--University of California, Riverside, 2016.
This item is not available from ProQuest Dissertations & Theses.
Graphene is a sp2 hybridized carbon, arranged perfectly in a honeycomb structure to form a 2D monolayer of graphitic structure. It has become a popular choice in the development of electrochemical/electrical biosensor devices due to its large surface area, faster electron transfer kinetics, tunable band gap and ultrahigh charge carrier mobility with ballistic electron transport. The goal of this work is to synthesize advanced graphene nanostructures with improved electrical and physiochemical properties suitable for the development of ultrasensitive electrical/electrochemical biosensors. In the first project, seamless graphene-carbon nanotubes (G-CNT) hybrid film was synthesized using a two-step chemical vapor deposition (CVD) method where carbon nanotubes (CNTs) are grown on already grown graphene film on copper foil using iron as a catalyst. This three-dimensional G-CNT hybrid film has been studied for its potential in achieving direct electron transfer (DET) of glucose oxidase (GOx) and its bioelectrocatalytic activity in glucose detection. The DET between GOx and electrochemically oxidized G-CNT electrode was studied using cyclic voltammetry which showed a pair of well-defined and quasi-reversible redox peaks with a formal potential of-459 mV at pH 7 corresponding to redox site of GOx. The constructed electrode detected glucose concentration over the clinically relevant range with the highest sensitivity compared to reported composite hybrid electrodes of graphene oxide and CNTs. G-CNT structure used in this work has potential to be used for development of artificial mediatorless redox enzymatic biosensors and biofuel cell. In the second project, an electrical transduction based biosensor platform for detection of biomolecular interaction using a graphene nanogap electrode has been developed. Different nanofabrication methods including focused ion beam milling (FIB), nanoidentation and E-Beam lithography (EBL) were studied in achieving reproducible planar nanogap electrodes of width less than 100 nm. Electrical biosensing concept was tested on nanogap electrodes using a high affinity interaction of streptavidin- biotin. Sensor performance was further optimized for achieving the high sensitive detection of streptavidin. The detection capability of this biosensor can be tuned down to the single to few molecules. Proposed biosensor platform can be used for any detection based on biomolecules affinity interaction such as for antigen-antibody or chemo-selective interaction with full potential to be used as a portable point-of-use biosensor.
ISBN: 9781369656848Subjects--Topical Terms:
3168300
Analytical chemistry.
Subjects--Index Terms:
Direct electron transfer
Advanced Graphene Nanostructures for Biosensing Applications.
LDR
:03981nmm a2200421 4500
001
2281004
005
20210913093647.5
008
220723s2016 ||||||||||||||||| ||eng d
020
$a
9781369656848
035
$a
(MiAaPQ)AAI10245752
035
$a
(MiAaPQ)ucr:12818
035
$a
AAI10245752
040
$a
MiAaPQ
$c
MiAaPQ
100
1
$a
Terse, Trupti Madhukar.
$3
3559584
245
1 0
$a
Advanced Graphene Nanostructures for Biosensing Applications.
260
1
$a
Ann Arbor :
$b
ProQuest Dissertations & Theses,
$c
2016
300
$a
152 p.
500
$a
Source: Dissertations Abstracts International, Volume: 78-09, Section: B.
500
$a
Publisher info.: Dissertation/Thesis.
500
$a
Advisor: Mulchandani, Ashok.
502
$a
Thesis (Ph.D.)--University of California, Riverside, 2016.
506
$a
This item is not available from ProQuest Dissertations & Theses.
506
$a
This item must not be sold to any third party vendors.
520
$a
Graphene is a sp2 hybridized carbon, arranged perfectly in a honeycomb structure to form a 2D monolayer of graphitic structure. It has become a popular choice in the development of electrochemical/electrical biosensor devices due to its large surface area, faster electron transfer kinetics, tunable band gap and ultrahigh charge carrier mobility with ballistic electron transport. The goal of this work is to synthesize advanced graphene nanostructures with improved electrical and physiochemical properties suitable for the development of ultrasensitive electrical/electrochemical biosensors. In the first project, seamless graphene-carbon nanotubes (G-CNT) hybrid film was synthesized using a two-step chemical vapor deposition (CVD) method where carbon nanotubes (CNTs) are grown on already grown graphene film on copper foil using iron as a catalyst. This three-dimensional G-CNT hybrid film has been studied for its potential in achieving direct electron transfer (DET) of glucose oxidase (GOx) and its bioelectrocatalytic activity in glucose detection. The DET between GOx and electrochemically oxidized G-CNT electrode was studied using cyclic voltammetry which showed a pair of well-defined and quasi-reversible redox peaks with a formal potential of-459 mV at pH 7 corresponding to redox site of GOx. The constructed electrode detected glucose concentration over the clinically relevant range with the highest sensitivity compared to reported composite hybrid electrodes of graphene oxide and CNTs. G-CNT structure used in this work has potential to be used for development of artificial mediatorless redox enzymatic biosensors and biofuel cell. In the second project, an electrical transduction based biosensor platform for detection of biomolecular interaction using a graphene nanogap electrode has been developed. Different nanofabrication methods including focused ion beam milling (FIB), nanoidentation and E-Beam lithography (EBL) were studied in achieving reproducible planar nanogap electrodes of width less than 100 nm. Electrical biosensing concept was tested on nanogap electrodes using a high affinity interaction of streptavidin- biotin. Sensor performance was further optimized for achieving the high sensitive detection of streptavidin. The detection capability of this biosensor can be tuned down to the single to few molecules. Proposed biosensor platform can be used for any detection based on biomolecules affinity interaction such as for antigen-antibody or chemo-selective interaction with full potential to be used as a portable point-of-use biosensor.
590
$a
School code: 0032.
650
4
$a
Analytical chemistry.
$3
3168300
650
4
$a
Nanotechnology.
$3
526235
650
4
$a
Materials science.
$3
543314
653
$a
Direct electron transfer
653
$a
Electrical biosensor
653
$a
Glucose biosensing
653
$a
Glucose oxidase
653
$a
Graphene carbon nanotube hybrids
653
$a
Graphene nanogap
690
$a
0486
690
$a
0652
690
$a
0794
710
2
$a
University of California, Riverside.
$b
Bioengineering.
$3
3174138
773
0
$t
Dissertations Abstracts International
$g
78-09B.
790
$a
0032
791
$a
Ph.D.
792
$a
2016
793
$a
English
856
4 0
$u
https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10245752
筆 0 讀者評論
館藏地:
全部
電子資源
出版年:
卷號:
館藏
1 筆 • 頁數 1 •
1
條碼號
典藏地名稱
館藏流通類別
資料類型
索書號
使用類型
借閱狀態
預約狀態
備註欄
附件
W9432737
電子資源
11.線上閱覽_V
電子書
EB
一般使用(Normal)
在架
0
1 筆 • 頁數 1 •
1
多媒體
評論
新增評論
分享你的心得
Export
取書館
處理中
...
變更密碼
登入