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Engineered MEMS Microenvironments fo...

Perebikovsky, Alexandra.

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Engineered MEMS Microenvironments for Studying Stem Cells and Microorganisms.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Engineered MEMS Microenvironments for Studying Stem Cells and Microorganisms./
Author:	Perebikovsky, Alexandra.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2020,
Description:	199 p.
Notes:	Source: Dissertations Abstracts International, Volume: 82-02, Section: B.
Contained By:	Dissertations Abstracts International82-02B.
Subject:	Physics. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=27998856
ISBN:	9798662428393

Engineered MEMS Microenvironments for Studying Stem Cells and Microorganisms.
Perebikovsky, Alexandra.

Engineered MEMS Microenvironments for Studying Stem Cells and Microorganisms. - Ann Arbor : ProQuest Dissertations & Theses, 2020 - 199 p.

Source: Dissertations Abstracts International, Volume: 82-02, Section: B.

Thesis (Ph.D.)--University of California, Irvine, 2020.

This item must not be sold to any third party vendors.

Advances in miniaturization and nanofabrication techniques have led to significant medical breakthroughs, especially in the fields of stem cell therapy and medical diagnostics. In this contribution, we use MEMS techniques to develop two different tools that allow us to study different biological organisms: 1.) a multi-functional smart scaffold for studying stem cells, and 2.) a centrifugal microfluidic platform for studying microorganisms like bacteria. In Part II, we use the multi-functional smart scaffold to control neural stem cell growth/differentiation and simultaneously monitor Dopamine released from the cells. In Part III, we use the centrifugal microfluidic platform to optimize the incubation of multiple bacteria species. We then use the same platform to develop a sample-to-answer phenotypic antibiotic susceptbility test that successfully identifies resistance in 11 different species of E. Coli in under 2 hours.

ISBN: 9798662428393Subjects--Topical Terms:

516296
Physics.
Subjects--Index Terms:

Antibiotics

Engineered MEMS Microenvironments for Studying Stem Cells and Microorganisms.
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245 1 0 $a Engineered MEMS Microenvironments for Studying Stem Cells and Microorganisms.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2020
300 $a 199 p.
500 $a Source: Dissertations Abstracts International, Volume: 82-02, Section: B.
500 $a Advisor: Madou, Marc.
502 $a Thesis (Ph.D.)--University of California, Irvine, 2020.
506 $a This item must not be sold to any third party vendors.
520 $a Advances in miniaturization and nanofabrication techniques have led to significant medical breakthroughs, especially in the fields of stem cell therapy and medical diagnostics. In this contribution, we use MEMS techniques to develop two different tools that allow us to study different biological organisms: 1.) a multi-functional smart scaffold for studying stem cells, and 2.) a centrifugal microfluidic platform for studying microorganisms like bacteria. In Part II, we use the multi-functional smart scaffold to control neural stem cell growth/differentiation and simultaneously monitor Dopamine released from the cells. In Part III, we use the centrifugal microfluidic platform to optimize the incubation of multiple bacteria species. We then use the same platform to develop a sample-to-answer phenotypic antibiotic susceptbility test that successfully identifies resistance in 11 different species of E. Coli in under 2 hours.
590 $a School code: 0030.
650 4 $a Physics. $3 516296
650 4 $a Biophysics. $3 518360
650 4 $a Materials science. $3 543314
653 $a Antibiotics
653 $a MEMS
653 $a Microfabrication
653 $a Microfluidics
653 $a Scaffold
653 $a Stem cell
690 $a 0605
690 $a 0786
690 $a 0794
710 2 $a University of California, Irvine. $b Physics - Ph.D.. $3 2096691
773 0 $t Dissertations Abstracts International $g 82-02B.
790 $a 0030
791 $a Ph.D.
792 $a 2020
793 $a English
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=27998856