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Genomic Instability Induced by High ...

Goss, Rosalin.

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Genomic Instability Induced by High Energy Charged Particles.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Genomic Instability Induced by High Energy Charged Particles./
Author:	Goss, Rosalin.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2020,
Description:	57 p.
Notes:	Source: Dissertations Abstracts International, Volume: 81-12, Section: B.
Contained By:	Dissertations Abstracts International81-12B.
Subject:	Biology. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=27962826
ISBN:	9798641452241

Genomic Instability Induced by High Energy Charged Particles.
Goss, Rosalin.

Genomic Instability Induced by High Energy Charged Particles. - Ann Arbor : ProQuest Dissertations & Theses, 2020 - 57 p.

Source: Dissertations Abstracts International, Volume: 81-12, Section: B.

Thesis (Ph.D.)--Texas Southern University, 2020.

This item must not be sold to any third party vendors.

Space radiation is composed of abundant types of charged particles and is a major concern for astronaut's health. Particles of high atomic number and high energy (HZE) usually have high linear energy transfer (LET), whereas high-energy lighter ions, such as protons, have low energy transfer (LET). These ions produced double strand breaks (DSB) in deoxyribonucleic acid (DNA), which can result in genomic instability (GI). Two approaches for evaluating the effects of radiation is exposing human fibroblast cells to different radiation doses over a specific period and placing the fibroblast cells inside a T-25 flask inside a special designed payload mounted onto a pallet. The pallet mounted onto one of NASA's WB-57 flown 60,000 feet above sea level. An analysis of GI in Fibroblasts after Proton and Fe ions radiation using the fluorescence in-situ hybridization (FISH) technique. FISH technique has proved to be an accurate method for analysis of GI. FISH uses fluorescent probes to detect the position of specific DNA sequences on chromosomes. Proton and Iron (Fe) are two of the most abundant types of charged particles in deep space. Both charged particles produce ionization along their path. Protons are also low linear energy transfer (LET) because they are able to pass through matter without losing much energy, like gamma rays and x-rays. Protons has proven to induce DNA double strand breaks, which are one of the more dangerous DNA lesions, similar to that induced by high-energy ions. Proton and Fe- ions that are ion induced has shown to cause DNA damages, DNA damages may consist of deletion, insertion, ring or translocation based on the ionization. Higher levels of Fe radiation found in space is more likely to cause damage to DNA molecules than proton radiation. Exposure to radiation has significant health risk. Radiation induces several types of DNA damages. Unrepaired or wrong repaired DNA can lead to mutations and increase the number of chromosome aberrations induced by these HZE's. Cells that are susceptible to radiation damages factors are dependent on genomic background and growth.The wide range variety of deoxyribonucleic acid (DNA) damages that radiation produces remains a confusing factor in this study. This study will demonstrate several potentials of the effect that ionized induced radiation causes, as they may relate specifically to the induction of degenerative diseases by ionizing radiation.

ISBN: 9798641452241Subjects--Topical Terms:

522710
Biology.
Subjects--Index Terms:

Chromosomal aberration

Genomic Instability Induced by High Energy Charged Particles.
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500 $a Source: Dissertations Abstracts International, Volume: 81-12, Section: B.
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506 $a This item must not be sold to any third party vendors.
520 $a Space radiation is composed of abundant types of charged particles and is a major concern for astronaut's health. Particles of high atomic number and high energy (HZE) usually have high linear energy transfer (LET), whereas high-energy lighter ions, such as protons, have low energy transfer (LET). These ions produced double strand breaks (DSB) in deoxyribonucleic acid (DNA), which can result in genomic instability (GI). Two approaches for evaluating the effects of radiation is exposing human fibroblast cells to different radiation doses over a specific period and placing the fibroblast cells inside a T-25 flask inside a special designed payload mounted onto a pallet. The pallet mounted onto one of NASA's WB-57 flown 60,000 feet above sea level. An analysis of GI in Fibroblasts after Proton and Fe ions radiation using the fluorescence in-situ hybridization (FISH) technique. FISH technique has proved to be an accurate method for analysis of GI. FISH uses fluorescent probes to detect the position of specific DNA sequences on chromosomes. Proton and Iron (Fe) are two of the most abundant types of charged particles in deep space. Both charged particles produce ionization along their path. Protons are also low linear energy transfer (LET) because they are able to pass through matter without losing much energy, like gamma rays and x-rays. Protons has proven to induce DNA double strand breaks, which are one of the more dangerous DNA lesions, similar to that induced by high-energy ions. Proton and Fe- ions that are ion induced has shown to cause DNA damages, DNA damages may consist of deletion, insertion, ring or translocation based on the ionization. Higher levels of Fe radiation found in space is more likely to cause damage to DNA molecules than proton radiation. Exposure to radiation has significant health risk. Radiation induces several types of DNA damages. Unrepaired or wrong repaired DNA can lead to mutations and increase the number of chromosome aberrations induced by these HZE's. Cells that are susceptible to radiation damages factors are dependent on genomic background and growth.The wide range variety of deoxyribonucleic acid (DNA) damages that radiation produces remains a confusing factor in this study. This study will demonstrate several potentials of the effect that ionized induced radiation causes, as they may relate specifically to the induction of degenerative diseases by ionizing radiation.
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