東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

The Heart of the Matter: Cardiovascu...

Lee, Jordan Talmadge.

Linked to FindBook

Google Book

Amazon

博客來

The Heart of the Matter: Cardiovascular Vulnerability of Breast Cancer Survivors. Implications for Aerobic Capacity and Cardiovascular Risk.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The Heart of the Matter: Cardiovascular Vulnerability of Breast Cancer Survivors. Implications for Aerobic Capacity and Cardiovascular Risk./
Author:	Lee, Jordan Talmadge.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2020,
Description:	134 p.
Notes:	Source: Dissertations Abstracts International, Volume: 82-01, Section: B.
Contained By:	Dissertations Abstracts International82-01B.
Subject:	Physiology. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=27831976
ISBN:	9798641566078

The Heart of the Matter: Cardiovascular Vulnerability of Breast Cancer Survivors. Implications for Aerobic Capacity and Cardiovascular Risk.
Lee, Jordan Talmadge.

The Heart of the Matter: Cardiovascular Vulnerability of Breast Cancer Survivors. Implications for Aerobic Capacity and Cardiovascular Risk. - Ann Arbor : ProQuest Dissertations & Theses, 2020 - 134 p.

Source: Dissertations Abstracts International, Volume: 82-01, Section: B.

Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2020.

This item must not be sold to any third party vendors.

PURPOSE The purpose of this investigation was to improve understanding of the cardiovascular health and aerobic capacity profile of breast cancer survivors (BCS) and the role of community-based exercise to impact these profiles during early cancer survivorship. PARTICIPANTS Thirty-five early stage BCS who were within one year of completing either chemotherapy and/or radiation and twenty-one age-matched, sedentary, non-cancer controls (CTL) were enrolled for this study. METHODS: Applanation tonometry and cuff-based techniques were used to measure arterial stiffness (pulse wave velocity, augmentation index) and central hemodynamics (blood pressure, Buckberg Index). Cardiopulmonary exercise testing (CPET) on a cycle ergometer was used to evaluate aerobic capacity (VO2peak) before and after aerobic and strength exercise training 3 days per week for 16-weeks at a community-based training center. Linear mixed models were used to evaluate arterial stiffness and aerobic capacity between groups before and after exercise training. Exploratory univariate analyses investigated relationships between changes in arterial stiffness and aerobic capacity, respectively, with measures of exercise engagement. RESULTS Arterial stiffness between BCS and CTLs reflected that of healthy normal values at baseline and did not change following exercise. However, exploratory analyses of only BCS revealed significant increase in arterial stiffness regardless primary cancer treatment. Days of aerobic compliance were associated (R= -0.343, p=0.038) with pre-post change in PWV in a pooled sample. Aerobic capacity (1.2mL/kg/min; 95% CI [0.15, 2.27]; p=0.03) improved equitably between groups following training. Both groups attended 71% of prescribed days. Aerobic compliance was 54% for BCS, 67% for CTL and strength compliance was 29% for BCS and 38% for CTL. CONCLUSION Community-based exercise appears to be a promising route for cancer survivors to improve aerobic capacity, but more studies evaluating vascular health in BCS are needed to better understand our preliminary findings. Efforts to improve exercise compliance in community-based settings may improve ability to target specific physiological outcomes and unique needs of breast cancer survivors.

ISBN: 9798641566078Subjects--Topical Terms:

518431
Physiology.
Subjects--Index Terms:

Aerobic capacity

The Heart of the Matter: Cardiovascular Vulnerability of Breast Cancer Survivors. Implications for Aerobic Capacity and Cardiovascular Risk.
LDR:03507nmm a2200373 4500 001 2278656
005 20210712062236.5
008 220723s2020 ||||||||||||||||| ||eng d
020 $a 9798641566078
035 $a (MiAaPQ)AAI27831976
035 $a AAI27831976
040 $a MiAaPQ $c MiAaPQ
100 1 $a Lee, Jordan Talmadge. $3 3557038
245 1 4 $a The Heart of the Matter: Cardiovascular Vulnerability of Breast Cancer Survivors. Implications for Aerobic Capacity and Cardiovascular Risk.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2020
300 $a 134 p.
500 $a Source: Dissertations Abstracts International, Volume: 82-01, Section: B.
500 $a Advisor: Battaglini, Claudio L.
502 $a Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2020.
506 $a This item must not be sold to any third party vendors.
520 $a PURPOSE The purpose of this investigation was to improve understanding of the cardiovascular health and aerobic capacity profile of breast cancer survivors (BCS) and the role of community-based exercise to impact these profiles during early cancer survivorship. PARTICIPANTS Thirty-five early stage BCS who were within one year of completing either chemotherapy and/or radiation and twenty-one age-matched, sedentary, non-cancer controls (CTL) were enrolled for this study. METHODS: Applanation tonometry and cuff-based techniques were used to measure arterial stiffness (pulse wave velocity, augmentation index) and central hemodynamics (blood pressure, Buckberg Index). Cardiopulmonary exercise testing (CPET) on a cycle ergometer was used to evaluate aerobic capacity (VO2peak) before and after aerobic and strength exercise training 3 days per week for 16-weeks at a community-based training center. Linear mixed models were used to evaluate arterial stiffness and aerobic capacity between groups before and after exercise training. Exploratory univariate analyses investigated relationships between changes in arterial stiffness and aerobic capacity, respectively, with measures of exercise engagement. RESULTS Arterial stiffness between BCS and CTLs reflected that of healthy normal values at baseline and did not change following exercise. However, exploratory analyses of only BCS revealed significant increase in arterial stiffness regardless primary cancer treatment. Days of aerobic compliance were associated (R= -0.343, p=0.038) with pre-post change in PWV in a pooled sample. Aerobic capacity (1.2mL/kg/min; 95% CI [0.15, 2.27]; p=0.03) improved equitably between groups following training. Both groups attended 71% of prescribed days. Aerobic compliance was 54% for BCS, 67% for CTL and strength compliance was 29% for BCS and 38% for CTL. CONCLUSION Community-based exercise appears to be a promising route for cancer survivors to improve aerobic capacity, but more studies evaluating vascular health in BCS are needed to better understand our preliminary findings. Efforts to improve exercise compliance in community-based settings may improve ability to target specific physiological outcomes and unique needs of breast cancer survivors.
590 $a School code: 0153.
650 4 $a Physiology. $3 518431
650 4 $a Alternative medicine. $3 536195
653 $a Aerobic capacity
653 $a Arterial stiffness
653 $a Breast cancer
653 $a Cardiovascular
653 $a Exercise
653 $a Oncology
690 $a 0719
690 $a 0496
710 2 $a The University of North Carolina at Chapel Hill. $b Human Movement Science. $3 3435872
773 0 $t Dissertations Abstracts International $g 82-01B.
790 $a 0153
791 $a Ph.D.
792 $a 2020
793 $a English
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=27831976