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The Contributions of the Retrospleni...

Fournier, Danielle Irene.

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The Contributions of the Retrosplenial Cortex to Learning and Behavior.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The Contributions of the Retrosplenial Cortex to Learning and Behavior./
Author:	Fournier, Danielle Irene.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2021,
Description:	175 p.
Notes:	Source: Dissertations Abstracts International, Volume: 82-05, Section: B.
Contained By:	Dissertations Abstracts International82-05B.
Subject:	Neurosciences. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28153748
ISBN:	9798691217562

The Contributions of the Retrosplenial Cortex to Learning and Behavior.
Fournier, Danielle Irene.

The Contributions of the Retrosplenial Cortex to Learning and Behavior. - Ann Arbor : ProQuest Dissertations & Theses, 2021 - 175 p.

Source: Dissertations Abstracts International, Volume: 82-05, Section: B.

Thesis (Ph.D.)--Dartmouth College, 2021.

This item must not be sold to any third party vendors.

The ability to create, store, and retrieve memories is fundamental to everyday life in not only humans but all creatures. Humans' sense of self and quality of life are intimately tied with our capacity to remember and recall autobiographical memories. As a result, neurological diseases and disorders that impair learning and memory, such as Alzheimer's disease, severely impact quality of life. In order to provide better therapeutic options for those living with memory dysfunction, we must first better understand how and where memories are formed, stored, and retrieved. One approach to studying memory, and the one used throughout this dissertation, is through the usage of animal models. This model allows scientists to target and selectively manipulate specific brain regions to gain insight into their contributions to learning and memory. The retrosplenial cortex (RSC) is one brain region that has been consistently implicated in various forms of memory. However, the exact role of the RSC in forming and recalling memories is not clear. To address these open questions, I lesion or transiently inactivate the RSC during different phases of the learning or the memory retrieval process. Additionally, I manipulate the experimental parameters (e.g., type of stimuli, amount of training, and age of memory) in various standard associative learning paradigms to determine a possible mechanism of how the RSC contributes to forming the associations needed to create and remember a cohesive memory. The overarching conclusions are (1) the RSC is required for contextual fear memory under strong training parameters (2) the RSC contributes to single, discrete-cue fear memory retrieval, but not to discrete-cue encoding (3) the RSC contributes to forming associations between sensory stimuli. Moreover, these results allow me to conclude that the RSC is an integral part of the contextual fear learning and memory system and this region facilitates the formation of associations between environmental cues.

ISBN: 9798691217562Subjects--Topical Terms:

588700
Neurosciences.
Subjects--Index Terms:

Associative learning

The Contributions of the Retrosplenial Cortex to Learning and Behavior.
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500 $a Source: Dissertations Abstracts International, Volume: 82-05, Section: B.
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506 $a This item must not be sold to any third party vendors.
520 $a The ability to create, store, and retrieve memories is fundamental to everyday life in not only humans but all creatures. Humans' sense of self and quality of life are intimately tied with our capacity to remember and recall autobiographical memories. As a result, neurological diseases and disorders that impair learning and memory, such as Alzheimer's disease, severely impact quality of life. In order to provide better therapeutic options for those living with memory dysfunction, we must first better understand how and where memories are formed, stored, and retrieved. One approach to studying memory, and the one used throughout this dissertation, is through the usage of animal models. This model allows scientists to target and selectively manipulate specific brain regions to gain insight into their contributions to learning and memory. The retrosplenial cortex (RSC) is one brain region that has been consistently implicated in various forms of memory. However, the exact role of the RSC in forming and recalling memories is not clear. To address these open questions, I lesion or transiently inactivate the RSC during different phases of the learning or the memory retrieval process. Additionally, I manipulate the experimental parameters (e.g., type of stimuli, amount of training, and age of memory) in various standard associative learning paradigms to determine a possible mechanism of how the RSC contributes to forming the associations needed to create and remember a cohesive memory. The overarching conclusions are (1) the RSC is required for contextual fear memory under strong training parameters (2) the RSC contributes to single, discrete-cue fear memory retrieval, but not to discrete-cue encoding (3) the RSC contributes to forming associations between sensory stimuli. Moreover, these results allow me to conclude that the RSC is an integral part of the contextual fear learning and memory system and this region facilitates the formation of associations between environmental cues.
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