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Tagging Small Molecule Natural Produ...

Seidel, Jeremy A.

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Tagging Small Molecule Natural Products with Functional Chemical Probes to Enable New Techniques in the Discovery and Development of Pharmaceuticals.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Tagging Small Molecule Natural Products with Functional Chemical Probes to Enable New Techniques in the Discovery and Development of Pharmaceuticals./
Author:	Seidel, Jeremy A.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2020,
Description:	111 p.
Notes:	Source: Dissertations Abstracts International, Volume: 82-05, Section: B.
Contained By:	Dissertations Abstracts International82-05B.
Subject:	Chemical engineering. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28090529
ISBN:	9798691237348

Tagging Small Molecule Natural Products with Functional Chemical Probes to Enable New Techniques in the Discovery and Development of Pharmaceuticals.
Seidel, Jeremy A.

Tagging Small Molecule Natural Products with Functional Chemical Probes to Enable New Techniques in the Discovery and Development of Pharmaceuticals. - Ann Arbor : ProQuest Dissertations & Theses, 2020 - 111 p.

Source: Dissertations Abstracts International, Volume: 82-05, Section: B.

Thesis (Ph.D.)--University of California, Berkeley, 2020.

This item must not be sold to any third party vendors.

Humans have exploited small molecule natural products have exploited throughout history. Recently, advances in chemistry and biology have led to an explosion in drug development, revolutionizing the treatment of infectious diseases, cancer, and other ailments. However, current techniques have already been exploited nearly to their limits. The work described in this dissertation aims to expand the pharmacological potential of small molecule natural products by developing a range of techniques that exploit functional chemical tags that are chemically bonded to the small molecules. These tags enable natural products to be studied in new ways using techniques such as Raman microscopy, computational analysis of LCMS data, and optical lock-in detection of FRET. By fundamentally altering small molecule natural products, we have raised the possibility to discover and study drug-like molecules that would be inaccessible using traditional techniques.

ISBN: 9798691237348Subjects--Topical Terms:

560457
Chemical engineering.
Subjects--Index Terms:

Drug discovery

Tagging Small Molecule Natural Products with Functional Chemical Probes to Enable New Techniques in the Discovery and Development of Pharmaceuticals.
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500 $a Source: Dissertations Abstracts International, Volume: 82-05, Section: B.
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506 $a This item must not be sold to any third party vendors.
520 $a Humans have exploited small molecule natural products have exploited throughout history. Recently, advances in chemistry and biology have led to an explosion in drug development, revolutionizing the treatment of infectious diseases, cancer, and other ailments. However, current techniques have already been exploited nearly to their limits. The work described in this dissertation aims to expand the pharmacological potential of small molecule natural products by developing a range of techniques that exploit functional chemical tags that are chemically bonded to the small molecules. These tags enable natural products to be studied in new ways using techniques such as Raman microscopy, computational analysis of LCMS data, and optical lock-in detection of FRET. By fundamentally altering small molecule natural products, we have raised the possibility to discover and study drug-like molecules that would be inaccessible using traditional techniques.
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