語系:
繁體中文
English
說明(常見問題)
回圖書館首頁
手機版館藏查詢
登入
回首頁
切換:
標籤
|
MARC模式
|
ISBD
Titanium Micromachining Process Adva...
~
Corber, Samantha R.
FindBook
Google Book
Amazon
博客來
Titanium Micromachining Process Advancements for Optical Tissue Clearing.
紀錄類型:
書目-電子資源 : Monograph/item
正題名/作者:
Titanium Micromachining Process Advancements for Optical Tissue Clearing./
作者:
Corber, Samantha R.
出版者:
Ann Arbor : ProQuest Dissertations & Theses, : 2020,
面頁冊數:
95 p.
附註:
Source: Dissertations Abstracts International, Volume: 82-02, Section: B.
Contained By:
Dissertations Abstracts International82-02B.
標題:
Mechanical engineering. -
電子資源:
https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=27997782
ISBN:
9798664719260
Titanium Micromachining Process Advancements for Optical Tissue Clearing.
Corber, Samantha R.
Titanium Micromachining Process Advancements for Optical Tissue Clearing.
- Ann Arbor : ProQuest Dissertations & Theses, 2020 - 95 p.
Source: Dissertations Abstracts International, Volume: 82-02, Section: B.
Thesis (Ph.D.)--University of California, Riverside, 2020.
This item must not be sold to any third party vendors.
Optical Clearing Agents (OCAs) increase the transmittance of light through tissues, which represents a key step toward laser-based medical diagnostics and treatments. The stratum corneum is the key limitation to the transport of topically-applied OCA through the skin. While a bolus, subdermal injection overcomes the stratum corneum barrier, it can result in scarring and necrosis of the tissue; signifying a need for alternative drug delivery methods. One such alternative is the microneedle array, which can bypass the stratum corneum and overcome the low profusion of OCA by direct and evenly distributed injection into the tissue.Current materials being used to fabricate microneedles, such as silicon, are non-ideal for intradermal drug delivery due to their non-optimal material properties. Titanium is a promising surrogate material in this regard, due to its excellent biocompatibility and fracture toughness. The recent development of Titanium Deep Reactive Ion Etching (TiDRIE) has enabled the fabrication of small-scale, titanium-based biomedical devices. However, this micromachining technique was developed for anisotropic deep etching, which limits microdevice design and complexity, but provides opportunity for improvements in sidewall profile control.Herein, we explore two key objectives to the overall aim of increasing OCA efficacy through microneedle arrays. First, injection of OCA via a hypodermic needle array device is demonstrated to increase clearing efficacy in excised tissue in a proof-of-concept study. Next, multidimensional features were realized through the development and integration of profile control methods in TiDRIE that ultimately enabled the fabrication of the first dry etched out-of-plane bulk titanium microneedles.
ISBN: 9798664719260Subjects--Topical Terms:
649730
Mechanical engineering.
Subjects--Index Terms:
Deep Reactive Ion Etching
Titanium Micromachining Process Advancements for Optical Tissue Clearing.
LDR
:02975nmm a2200385 4500
001
2276879
005
20210510092431.5
008
220723s2020 ||||||||||||||||| ||eng d
020
$a
9798664719260
035
$a
(MiAaPQ)AAI27997782
035
$a
AAI27997782
040
$a
MiAaPQ
$c
MiAaPQ
100
1
$a
Corber, Samantha R.
$3
3555180
245
1 0
$a
Titanium Micromachining Process Advancements for Optical Tissue Clearing.
260
1
$a
Ann Arbor :
$b
ProQuest Dissertations & Theses,
$c
2020
300
$a
95 p.
500
$a
Source: Dissertations Abstracts International, Volume: 82-02, Section: B.
500
$a
Advisor: Rao, Masaru.
502
$a
Thesis (Ph.D.)--University of California, Riverside, 2020.
506
$a
This item must not be sold to any third party vendors.
520
$a
Optical Clearing Agents (OCAs) increase the transmittance of light through tissues, which represents a key step toward laser-based medical diagnostics and treatments. The stratum corneum is the key limitation to the transport of topically-applied OCA through the skin. While a bolus, subdermal injection overcomes the stratum corneum barrier, it can result in scarring and necrosis of the tissue; signifying a need for alternative drug delivery methods. One such alternative is the microneedle array, which can bypass the stratum corneum and overcome the low profusion of OCA by direct and evenly distributed injection into the tissue.Current materials being used to fabricate microneedles, such as silicon, are non-ideal for intradermal drug delivery due to their non-optimal material properties. Titanium is a promising surrogate material in this regard, due to its excellent biocompatibility and fracture toughness. The recent development of Titanium Deep Reactive Ion Etching (TiDRIE) has enabled the fabrication of small-scale, titanium-based biomedical devices. However, this micromachining technique was developed for anisotropic deep etching, which limits microdevice design and complexity, but provides opportunity for improvements in sidewall profile control.Herein, we explore two key objectives to the overall aim of increasing OCA efficacy through microneedle arrays. First, injection of OCA via a hypodermic needle array device is demonstrated to increase clearing efficacy in excised tissue in a proof-of-concept study. Next, multidimensional features were realized through the development and integration of profile control methods in TiDRIE that ultimately enabled the fabrication of the first dry etched out-of-plane bulk titanium microneedles.
590
$a
School code: 0032.
650
4
$a
Mechanical engineering.
$3
649730
650
4
$a
Biomedical engineering.
$3
535387
650
4
$a
Histology.
$3
641250
653
$a
Deep Reactive Ion Etching
653
$a
Isotropic etching
653
$a
Microneedles
653
$a
Optical Tissue Clearing
653
$a
Titanium
653
$a
Window to the Brain
690
$a
0548
690
$a
0541
690
$a
0414
710
2
$a
University of California, Riverside.
$b
Mechanical Engineering.
$3
1680544
773
0
$t
Dissertations Abstracts International
$g
82-02B.
790
$a
0032
791
$a
Ph.D.
792
$a
2020
793
$a
English
856
4 0
$u
https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=27997782
筆 0 讀者評論
館藏地:
全部
電子資源
出版年:
卷號:
館藏
1 筆 • 頁數 1 •
1
條碼號
典藏地名稱
館藏流通類別
資料類型
索書號
使用類型
借閱狀態
預約狀態
備註欄
附件
W9428613
電子資源
11.線上閱覽_V
電子書
EB
一般使用(Normal)
在架
0
1 筆 • 頁數 1 •
1
多媒體
評論
新增評論
分享你的心得
Export
取書館
處理中
...
變更密碼
登入