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Characterizing the Function of GAS1 ...

Li, Liangji.

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Characterizing the Function of GAS1 in Muscle Stem Cells Aging.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Characterizing the Function of GAS1 in Muscle Stem Cells Aging./
作者:	Li, Liangji.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2019,
面頁冊數:	164 p.
附註:	Source: Dissertations Abstracts International, Volume: 81-08, Section: B.
Contained By:	Dissertations Abstracts International81-08B.
標題:	Cellular biology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=27805514
ISBN:	9781392775028

Characterizing the Function of GAS1 in Muscle Stem Cells Aging.
Li, Liangji.

Characterizing the Function of GAS1 in Muscle Stem Cells Aging. - Ann Arbor : ProQuest Dissertations & Theses, 2019 - 164 p.

Source: Dissertations Abstracts International, Volume: 81-08, Section: B.

Thesis (Ph.D.)--The Johns Hopkins University, 2019.

This item must not be sold to any third party vendors.

Muscle undergoes progressive weakening and regenerative dysfunction with age due in part to the functional decline of skeletal muscle stem cells (MuSCs). MuSCs are heterogeneous but whether their gene expression changes with age and the implication of such changes are unclear. Here I show that in mice, the membrane protein Growth arrest-specific gene 1 (Gas1) is expressed in a small subset of young MuSCs with its expression progressively increasing in larger fractions of MuSCs later in life. I present genetic evidence that Gas1 reduces the quiescence and self-renewal capacity of MuSCs, via over-expression of Gas1 in young MuSCs and inactivation of Gas1 in aged MuSCs. I further show that Gas1 reduces Ret signaling, which is required for MuSC quiescence and self-renewal. I demonstrate that the Ret ligand, Glial Cell-Derived Neurotrophic Factor (GDNF), can counteract Gas1 by stimulating Ret signaling and enhancing MuSC self-renewal and regeneration, thus improving muscle function. I propose that strategies aimed to target this pathway can be exploited to improve the regenerative decline of muscle stem cells.

ISBN: 9781392775028Subjects--Topical Terms:

3172791
Cellular biology.
Subjects--Index Terms:

Stem cells

Characterizing the Function of GAS1 in Muscle Stem Cells Aging.
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