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Massively Parallel Genetic Disruptio...

Geller, Evan Todd Butcher.

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Massively Parallel Genetic Disruption of Enhancers Active during Human Corticogenesis.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Massively Parallel Genetic Disruption of Enhancers Active during Human Corticogenesis./
作者:	Geller, Evan Todd Butcher.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2019,
面頁冊數:	132 p.
附註:	Source: Dissertations Abstracts International, Volume: 81-10, Section: B.
Contained By:	Dissertations Abstracts International81-10B.
標題:	Genetics. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=22583376
ISBN:	9798607312770

Massively Parallel Genetic Disruption of Enhancers Active during Human Corticogenesis.
Geller, Evan Todd Butcher.

Massively Parallel Genetic Disruption of Enhancers Active during Human Corticogenesis. - Ann Arbor : ProQuest Dissertations & Theses, 2019 - 132 p.

Source: Dissertations Abstracts International, Volume: 81-10, Section: B.

Thesis (Ph.D.)--Yale University, 2019.

This item must not be sold to any third party vendors.

Human corticogenesis depends on the precise spatial, temporal, and quantitative control of developmental gene expression by transcriptional enhancers. However, the biological effects of genetic changes occurring within enhancers active during human cortical development have not been experimentally studied. We used sgRNA-Cas9 genetic screening to identify genes and enhancers that are required for the normal proliferation of human neural stem cells. Genes impacting proliferation are significantly enriched for functions in chromatin remodeling, cell division, and DNA repair as well as human brain phenotypes including primary microcephaly and autism spectrum disorders. Conserved regions within enhancers active during human corticogenesis are enriched for transcription factor binding related to cell cycle regulation and response to developmental signaling molecules. Integration with high-resolution chromatin interaction between genes and enhancers led to the discovery of developmental gene regulatory relationships, providing insights into possible mechanisms of human cortical development and evolution.

ISBN: 9798607312770Subjects--Topical Terms:

530508
Genetics.
Subjects--Index Terms:

Development

Massively Parallel Genetic Disruption of Enhancers Active during Human Corticogenesis.
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