東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Mechanisms of Post-transcriptional C...

Zahr, Siraj.

Linked to FindBook

Google Book

Amazon

博客來

Mechanisms of Post-transcriptional Control in Mammalian Neural Stem Cells.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Mechanisms of Post-transcriptional Control in Mammalian Neural Stem Cells./
Author:	Zahr, Siraj.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2019,
Description:	252 p.
Notes:	Source: Dissertations Abstracts International, Volume: 81-05, Section: B.
Contained By:	Dissertations Abstracts International81-05B.
Subject:	Developmental biology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=13899951
ISBN:	9781392526088

Mechanisms of Post-transcriptional Control in Mammalian Neural Stem Cells.
Zahr, Siraj.

Mechanisms of Post-transcriptional Control in Mammalian Neural Stem Cells. - Ann Arbor : ProQuest Dissertations & Theses, 2019 - 252 p.

Source: Dissertations Abstracts International, Volume: 81-05, Section: B.

Thesis (Ph.D.)--University of Toronto (Canada), 2019.

This item must not be sold to any third party vendors.

The diverse types of neurons that populate the mammalian forebrain are the fundamental requirement for the assembly of complex circuitry. However, the mechanisms regulating the genesis of these distinct neuronal populations from neural precursor cells (NPCs) are still not well understood. In this thesis, I address the question of whether post-transcriptional mechanisms regulate neuronal differentiation and fate specification within the developing forebrain. First, I show that embryonic NPCs are transcriptionally primed to make diverse neuronal subtypes, and that a Pum2-4E-T complex represses the translation of neuronal specifier mRNAs to ensure the appropriate temporal specification of daughter neurons. Second, I show that 4E-T mediated translational repression continues to act as a critical regulator of NPC maintenance and differentiation at postnatal stages. Based on the work presented in this thesis, I propose that translational repression mechanisms act to ensure the appropriate differentiation of transcriptionally primed NPCs in response to rapidly changing environmental cues.

ISBN: 9781392526088Subjects--Topical Terms:

592588
Developmental biology.
Subjects--Index Terms:

Cell fate specification

Mechanisms of Post-transcriptional Control in Mammalian Neural Stem Cells.
LDR:02367nmm a2200409 4500 001 2272632
005 20201105110143.5
008 220629s2019 ||||||||||||||||| ||eng d
020 $a 9781392526088
035 $a (MiAaPQ)AAI13899951
035 $a AAI13899951
040 $a MiAaPQ $c MiAaPQ
100 1 $a Zahr, Siraj. $3 3550059
245 1 0 $a Mechanisms of Post-transcriptional Control in Mammalian Neural Stem Cells.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2019
300 $a 252 p.
500 $a Source: Dissertations Abstracts International, Volume: 81-05, Section: B.
500 $a Advisor: Miller, Freda.
502 $a Thesis (Ph.D.)--University of Toronto (Canada), 2019.
506 $a This item must not be sold to any third party vendors.
520 $a The diverse types of neurons that populate the mammalian forebrain are the fundamental requirement for the assembly of complex circuitry. However, the mechanisms regulating the genesis of these distinct neuronal populations from neural precursor cells (NPCs) are still not well understood. In this thesis, I address the question of whether post-transcriptional mechanisms regulate neuronal differentiation and fate specification within the developing forebrain. First, I show that embryonic NPCs are transcriptionally primed to make diverse neuronal subtypes, and that a Pum2-4E-T complex represses the translation of neuronal specifier mRNAs to ensure the appropriate temporal specification of daughter neurons. Second, I show that 4E-T mediated translational repression continues to act as a critical regulator of NPC maintenance and differentiation at postnatal stages. Based on the work presented in this thesis, I propose that translational repression mechanisms act to ensure the appropriate differentiation of transcriptionally primed NPCs in response to rapidly changing environmental cues.
590 $a School code: 0779.
650 4 $a Developmental biology. $3 592588
650 4 $a Cellular biology. $3 3172791
650 4 $a Neurosciences. $3 588700
650 4 $a Physiology. $3 518431
650 4 $a Health sciences. $3 3168359
653 $a Cell fate specification
653 $a Immunohistochemistry
653 $a Neocortex
653 $a Neural stem cells
653 $a Post-transcriptional control
653 $a Single-cell RNA sequencing
690 $a 0758
690 $a 0379
690 $a 0317
690 $a 0566
690 $a 0719
710 2 $a University of Toronto (Canada). $b Medical Science. $3 3182952
773 0 $t Dissertations Abstracts International $g 81-05B.
790 $a 0779
791 $a Ph.D.
792 $a 2019
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=13899951