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Determinants of Altered Brain Develo...

de Guzman, A. Elizabeth.

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Determinants of Altered Brain Development from Cranial Radiation Therapy.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Determinants of Altered Brain Development from Cranial Radiation Therapy./
作者:	de Guzman, A. Elizabeth.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2019,
面頁冊數:	164 p.
附註:	Source: Dissertations Abstracts International, Volume: 81-06, Section: B.
Contained By:	Dissertations Abstracts International81-06B.
標題:	Neurosciences. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=13880093
ISBN:	9781392756324

Determinants of Altered Brain Development from Cranial Radiation Therapy.
de Guzman, A. Elizabeth.

Determinants of Altered Brain Development from Cranial Radiation Therapy. - Ann Arbor : ProQuest Dissertations & Theses, 2019 - 164 p.

Source: Dissertations Abstracts International, Volume: 81-06, Section: B.

Thesis (Ph.D.)--University of Toronto (Canada), 2019.

This item must not be sold to any third party vendors.

Approximately 15% of children diagnosed with cancer will receive radiation therapy treatment to part or all of the central nervous system. In this population, 5-year event-free survival rates are as high as 75%. While an effective treatment modality, cranial radiation therapy results in changes to normal brain development, manifesting as long-term deficits in brain structure and function in these children. Clinical studies and preclinical research have characterized different facets of radiation response, but the relative contributions of each to altered development is unclear. Presented in this thesis are experiments designed to investigate if manipulation of the radiation response can rescue long-term neuroanatomic development in the mouse. High-throughput MRI and genetically engineered mouse lines were exploited to test different treatment, demographic and cellular-response variables. First, younger age at treatment and increasing radiation dose, factors that increase risk for cognitive dysfunction in paediatric patients, were found to increase structural deficits in the mouse brain. Second, reduction of radiation-induced programmed cell death and chronic inflammation, by genetic manipulation, were shown to reduce neuroanatomic volume loss. Finally, since being of the female sex has also been suggested as a risk-factor, the outcome of all these experiments were compared between males and females. It was demonstrated that manipulation of the inflammatory response had different effects on neuroanatomical outcome depending on sex. These studies provide a foundation for future research aimed at developing interventions for mitigating long-term neurocognitive deficits in survivors of paediatric cancer.

ISBN: 9781392756324Subjects--Topical Terms:

588700
Neurosciences.
Subjects--Index Terms:

brain development

Determinants of Altered Brain Development from Cranial Radiation Therapy.
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