東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

The Fate, Metabolism and Toxicity of...

Dudley, Stacia L.

FindBook

Google Book

Amazon

博客來

The Fate, Metabolism and Toxicity of Select Contaminants of Emerging Concern in Terrestrial Environments.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	The Fate, Metabolism and Toxicity of Select Contaminants of Emerging Concern in Terrestrial Environments./
作者:	Dudley, Stacia L.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2019,
面頁冊數:	177 p.
附註:	Source: Dissertations Abstracts International, Volume: 80-12, Section: B.
Contained By:	Dissertations Abstracts International80-12B.
標題:	Toxicology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=13808245
ISBN:	9781392170564

The Fate, Metabolism and Toxicity of Select Contaminants of Emerging Concern in Terrestrial Environments.
Dudley, Stacia L.

The Fate, Metabolism and Toxicity of Select Contaminants of Emerging Concern in Terrestrial Environments. - Ann Arbor : ProQuest Dissertations & Theses, 2019 - 177 p.

Source: Dissertations Abstracts International, Volume: 80-12, Section: B.

Thesis (Ph.D.)--University of California, Riverside, 2019.

This item is not available from ProQuest Dissertations & Theses.

Increasing populations and shifting precipitation patterns put pressure on freshwater and food systems and incentivize governments and industries to exploit historically underutilized resources, such as recycled water and biosolids. Use of recycled water and biosolids in agricultural systems, however, comes with the potential risks of environmental and food contamination by trace organic contaminants including, contaminants of emerging concern (CECs). These compounds pose potential threats to humans and environmental health because they are designed to be biologically active at low concentrations and are considered "pseudo-persistent" due to their continuous release into the environment.Using 14C tracing, mass spectrometry, stable-isotope labeling, and enzyme extractions to assess the fate, metabolism, and biological effects of four environmentally prevalent CECs (i.e. sulfamethoxazole, diazepam, naproxen and methyl paraben) in terrestrial organisms in hydroponic and artificial soil cultivations. These organisms included an agricultural bioengineer (Eisiena fetida), a model plant (Arabidopsis thaliana) and two crop plants (Cucumis sativus, Raphanus sativus,). Compounds were selected based on environmental prevalence and test organisms were selected due to their use in the literature, commercial availability, and global range.Sulfamethoxazole was metabolized in A. thaliana cell cultures, and E. Fetida forming phase I and II metabolites. Diazepam was also metabolized in A. thaliana cell cultures and radish and cucumber seedlings, forming the phase I metabolites nordiazepam, temazepam and oxazepam, with the longevity corresponding to that of human metabolism. The major metabolites of naproxen and methyl paraben, O-desmethylnaproxen and p-hydroxybenzoic acid, respectively, were detected in treatment soils containing E. fetida and N4-acetylsulfamethoxazole was detected in E. fetida tissues, indicating CEC metabolism and excretion. Exposure to CECs resulted in changes to enzymes associated with detoxification and oxidative stress (i.e. glutathione-S-transerfase, glucuronosyl transferase, superoxide dismutase, and catalase) in crop plants and E. fetida. Our research indicates that terrestrial organisms can take and transform CECs and that CECs can change biochemistry of the exposed organisms. Accordingly, it is crucial to consider CEC fate, transformation and effects on non-target organisms of CECs when assessing risk in the agro-environment.

ISBN: 9781392170564Subjects--Topical Terms:

556884
Toxicology.
Subjects--Index Terms:

Bioaccumulation

The Fate, Metabolism and Toxicity of Select Contaminants of Emerging Concern in Terrestrial Environments.
LDR:03856nmm a2200409 4500 001 2272395
005 20201105110045.5
008 220629s2019 ||||||||||||||||| ||eng d
020 $a 9781392170564
035 $a (MiAaPQ)AAI13808245
035 $a (MiAaPQ)ucr:13680
035 $a AAI13808245
040 $a MiAaPQ $c MiAaPQ
100 1 $a Dudley, Stacia L. $3 3549832
245 1 4 $a The Fate, Metabolism and Toxicity of Select Contaminants of Emerging Concern in Terrestrial Environments.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2019
300 $a 177 p.
500 $a Source: Dissertations Abstracts International, Volume: 80-12, Section: B.
500 $a Publisher info.: Dissertation/Thesis.
500 $a Advisor: Gan, Jay.
502 $a Thesis (Ph.D.)--University of California, Riverside, 2019.
506 $a This item is not available from ProQuest Dissertations & Theses.
506 $a This item must not be sold to any third party vendors.
520 $a Increasing populations and shifting precipitation patterns put pressure on freshwater and food systems and incentivize governments and industries to exploit historically underutilized resources, such as recycled water and biosolids. Use of recycled water and biosolids in agricultural systems, however, comes with the potential risks of environmental and food contamination by trace organic contaminants including, contaminants of emerging concern (CECs). These compounds pose potential threats to humans and environmental health because they are designed to be biologically active at low concentrations and are considered "pseudo-persistent" due to their continuous release into the environment.Using 14C tracing, mass spectrometry, stable-isotope labeling, and enzyme extractions to assess the fate, metabolism, and biological effects of four environmentally prevalent CECs (i.e. sulfamethoxazole, diazepam, naproxen and methyl paraben) in terrestrial organisms in hydroponic and artificial soil cultivations. These organisms included an agricultural bioengineer (Eisiena fetida), a model plant (Arabidopsis thaliana) and two crop plants (Cucumis sativus, Raphanus sativus,). Compounds were selected based on environmental prevalence and test organisms were selected due to their use in the literature, commercial availability, and global range.Sulfamethoxazole was metabolized in A. thaliana cell cultures, and E. Fetida forming phase I and II metabolites. Diazepam was also metabolized in A. thaliana cell cultures and radish and cucumber seedlings, forming the phase I metabolites nordiazepam, temazepam and oxazepam, with the longevity corresponding to that of human metabolism. The major metabolites of naproxen and methyl paraben, O-desmethylnaproxen and p-hydroxybenzoic acid, respectively, were detected in treatment soils containing E. fetida and N4-acetylsulfamethoxazole was detected in E. fetida tissues, indicating CEC metabolism and excretion. Exposure to CECs resulted in changes to enzymes associated with detoxification and oxidative stress (i.e. glutathione-S-transerfase, glucuronosyl transferase, superoxide dismutase, and catalase) in crop plants and E. fetida. Our research indicates that terrestrial organisms can take and transform CECs and that CECs can change biochemistry of the exposed organisms. Accordingly, it is crucial to consider CEC fate, transformation and effects on non-target organisms of CECs when assessing risk in the agro-environment.
590 $a School code: 0032.
650 4 $a Toxicology. $3 556884
650 4 $a Environmental science. $3 677245
653 $a Bioaccumulation
653 $a Contaminants of emerging concern
653 $a E. fetida
653 $a Metabolism
653 $a Oxidative stress
653 $a Plant uptake
690 $a 0383
690 $a 0768
710 2 $a University of California, Riverside. $b Environmental Toxicology. $3 3278739
773 0 $t Dissertations Abstracts International $g 80-12B.
790 $a 0032
791 $a Ph.D.
792 $a 2019
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=13808245