東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Molecular Underpinnings of Pluripote...

Buitrago Delgado, Elsy Cristina.

Linked to FindBook

Google Book

Amazon

博客來

Molecular Underpinnings of Pluripotency Suggest a Novel Origin for Neural Crest Stem Cells and a New Theory for Evolution of Vertebrates.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Molecular Underpinnings of Pluripotency Suggest a Novel Origin for Neural Crest Stem Cells and a New Theory for Evolution of Vertebrates./
Author:	Buitrago Delgado, Elsy Cristina.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2018,
Description:	178 p.
Notes:	Source: Dissertations Abstracts International, Volume: 80-06, Section: B.
Contained By:	Dissertations Abstracts International80-06B.
Subject:	Molecular biology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=13419192
ISBN:	9780438773684

Molecular Underpinnings of Pluripotency Suggest a Novel Origin for Neural Crest Stem Cells and a New Theory for Evolution of Vertebrates.
Buitrago Delgado, Elsy Cristina.

Molecular Underpinnings of Pluripotency Suggest a Novel Origin for Neural Crest Stem Cells and a New Theory for Evolution of Vertebrates. - Ann Arbor : ProQuest Dissertations & Theses, 2018 - 178 p.

Source: Dissertations Abstracts International, Volume: 80-06, Section: B.

Thesis (Ph.D.)--Northwestern University, 2018.

This item must not be sold to any third party vendors.

Neural crest cells are a population of multipotent stem cells that are unique to vertebrates and give rise to a wide range of derivatives in the developing embryo, including elements of the craniofacial skeleton, pigmentation of the skin and peripheral nervous system. Although these cells reside in the ectoderm, they generate cell types typically categorized as mesodermal, and their broad developmental potential persists past the time when most ectoderm-derived cells have become lineage restricted. We recently proposed a new model for the developmental and evolutionary origins of neural crest cells based on the strikingly conserved molecular underpinnings of potency observed in these cells and pluripotent blastula stem cells. We suggest that neural crest cells may have evolved as a consequence of a subset of pluripotent blastula cells retaining the activity of much of the regulatory network underlying pluripotency through gastrula stages. A striking difference in the regulatory factors expressed in pluripotent blastula cells and neural crest cells is the deployment of different sub-families of Sox transcription factors. Whereas SoxB1 factors are known to play central roles in pluripotent blastula and ES cells, neural crest cells express high levels of SoxE family transcription factors. I explored the role that this molecular "hand-off" of Sox factor activity, from SoxB1 to SoxE, play in the retention of pluripotency and the subsequent biasing of cells to contribute to specific neural crest-derived lineages by probing the shared and distinct activities of these factors in early Xenopus embryos.

ISBN: 9780438773684Subjects--Topical Terms:

517296
Molecular biology.
Subjects--Index Terms:

Neural crest cells

Molecular Underpinnings of Pluripotency Suggest a Novel Origin for Neural Crest Stem Cells and a New Theory for Evolution of Vertebrates.
LDR:02935nmm a2200397 4500 001 2272330
005 20201105110022.5
008 220629s2018 ||||||||||||||||| ||eng d
020 $a 9780438773684
035 $a (MiAaPQ)AAI13419192
035 $a (MiAaPQ)northwestern:14468
035 $a AAI13419192
040 $a MiAaPQ $c MiAaPQ
100 1 $a Buitrago Delgado, Elsy Cristina. $3 3549765
245 1 0 $a Molecular Underpinnings of Pluripotency Suggest a Novel Origin for Neural Crest Stem Cells and a New Theory for Evolution of Vertebrates.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2018
300 $a 178 p.
500 $a Source: Dissertations Abstracts International, Volume: 80-06, Section: B.
500 $a Publisher info.: Dissertation/Thesis.
500 $a Advisor: LaBonne, Carole;Carthew, Richard.
502 $a Thesis (Ph.D.)--Northwestern University, 2018.
506 $a This item must not be sold to any third party vendors.
520 $a Neural crest cells are a population of multipotent stem cells that are unique to vertebrates and give rise to a wide range of derivatives in the developing embryo, including elements of the craniofacial skeleton, pigmentation of the skin and peripheral nervous system. Although these cells reside in the ectoderm, they generate cell types typically categorized as mesodermal, and their broad developmental potential persists past the time when most ectoderm-derived cells have become lineage restricted. We recently proposed a new model for the developmental and evolutionary origins of neural crest cells based on the strikingly conserved molecular underpinnings of potency observed in these cells and pluripotent blastula stem cells. We suggest that neural crest cells may have evolved as a consequence of a subset of pluripotent blastula cells retaining the activity of much of the regulatory network underlying pluripotency through gastrula stages. A striking difference in the regulatory factors expressed in pluripotent blastula cells and neural crest cells is the deployment of different sub-families of Sox transcription factors. Whereas SoxB1 factors are known to play central roles in pluripotent blastula and ES cells, neural crest cells express high levels of SoxE family transcription factors. I explored the role that this molecular "hand-off" of Sox factor activity, from SoxB1 to SoxE, play in the retention of pluripotency and the subsequent biasing of cells to contribute to specific neural crest-derived lineages by probing the shared and distinct activities of these factors in early Xenopus embryos.
590 $a School code: 0163.
650 4 $a Molecular biology. $3 517296
650 4 $a Developmental biology. $3 592588
653 $a Neural crest cells
653 $a Pluripotency
653 $a SoxB1
653 $a SoxE
653 $a Stem cells
653 $a Xenopus
690 $a 0307
690 $a 0758
710 2 $a Northwestern University. $b Music. $3 3277730
773 0 $t Dissertations Abstracts International $g 80-06B.
790 $a 0163
791 $a Ph.D.
792 $a 2018
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=13419192