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Transrectal Diffuse Optical Tomograp...

He, Jie.

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Transrectal Diffuse Optical Tomography Monitoring of Photothermal Therapy for Localized Prostate Cancer.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Transrectal Diffuse Optical Tomography Monitoring of Photothermal Therapy for Localized Prostate Cancer./
Author:	He, Jie.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2018,
Description:	223 p.
Notes:	Source: Dissertations Abstracts International, Volume: 80-06, Section: B.
Contained By:	Dissertations Abstracts International80-06B.
Subject:	Biomedical engineering. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10973914
ISBN:	9780438684959

Transrectal Diffuse Optical Tomography Monitoring of Photothermal Therapy for Localized Prostate Cancer.
He, Jie.

Transrectal Diffuse Optical Tomography Monitoring of Photothermal Therapy for Localized Prostate Cancer. - Ann Arbor : ProQuest Dissertations & Theses, 2018 - 223 p.

Source: Dissertations Abstracts International, Volume: 80-06, Section: B.

Thesis (Ph.D.)--University of Toronto (Canada), 2018.

This item is not available from ProQuest Dissertations & Theses.

The clinical management for localized, low- to intermediate-risk prostate cancer (PCa) has become more complex as more therapeutic options become available, while it remains very challenging as physicians try to find a treatment that offers both excellent oncological results and minimal morbidity. Photothermal therapy (PTT) is currently undergoing clinical trials and has shown potential to be one such technique. However, the clinical outcome of PTT is suboptimal, mainly due to the lack of direct monitoring of the coagulated lesion that is generated during PTT. Transrectal diffuse optical tomography (TRDOT) has been proposed to localize the photocoagulation boundary based on changes in tissue optical properties upon coagulation, particularly scattering. A baseline study of phantom experiments with corresponding numerical simulations was first conducted using an existing TRDOT system to investigate its signal sensitivity to a growing coagulating lesion. After gaining critical guidance in building an instrumentation, a clinical propotype TRDOT system, which comprises a 32-channel fiberoptic-based, MR-compatible transrectal probe, was designed and fabricated specifically for the clinical application of in vivo monitoring of PTT by localizing the boundary of the coagulated lesion. The performance of the instrument was tested and characterized. Calibration methods were developed for the system and the probe. The accuracy and reliability of calibrated TRDOT measurements were investigated and characterized in homogeneous phantoms. The in vivo feasibility of the system was tested in a canine PCa tumor model. TRDOT's ability in monitoring PTT and accuracy in localizing the boundary of a coagulated lesion were investigated through a series studies using thermal coagulating phantoms, ex vivo canine prostates, and in vivo canine prostate models. This demonstrates TRDOT's potential of visualization of the extent of coagulation during PTT, which will contribute improving PTT's safety and clinical outcome.

ISBN: 9780438684959Subjects--Topical Terms:

535387
Biomedical engineering.
Subjects--Index Terms:

Photothermal therapy

Transrectal Diffuse Optical Tomography Monitoring of Photothermal Therapy for Localized Prostate Cancer.
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500 $a Advisor: Wilson, Brian C.
502 $a Thesis (Ph.D.)--University of Toronto (Canada), 2018.
506 $a This item is not available from ProQuest Dissertations & Theses.
506 $a This item must not be sold to any third party vendors.
520 $a The clinical management for localized, low- to intermediate-risk prostate cancer (PCa) has become more complex as more therapeutic options become available, while it remains very challenging as physicians try to find a treatment that offers both excellent oncological results and minimal morbidity. Photothermal therapy (PTT) is currently undergoing clinical trials and has shown potential to be one such technique. However, the clinical outcome of PTT is suboptimal, mainly due to the lack of direct monitoring of the coagulated lesion that is generated during PTT. Transrectal diffuse optical tomography (TRDOT) has been proposed to localize the photocoagulation boundary based on changes in tissue optical properties upon coagulation, particularly scattering. A baseline study of phantom experiments with corresponding numerical simulations was first conducted using an existing TRDOT system to investigate its signal sensitivity to a growing coagulating lesion. After gaining critical guidance in building an instrumentation, a clinical propotype TRDOT system, which comprises a 32-channel fiberoptic-based, MR-compatible transrectal probe, was designed and fabricated specifically for the clinical application of in vivo monitoring of PTT by localizing the boundary of the coagulated lesion. The performance of the instrument was tested and characterized. Calibration methods were developed for the system and the probe. The accuracy and reliability of calibrated TRDOT measurements were investigated and characterized in homogeneous phantoms. The in vivo feasibility of the system was tested in a canine PCa tumor model. TRDOT's ability in monitoring PTT and accuracy in localizing the boundary of a coagulated lesion were investigated through a series studies using thermal coagulating phantoms, ex vivo canine prostates, and in vivo canine prostate models. This demonstrates TRDOT's potential of visualization of the extent of coagulation during PTT, which will contribute improving PTT's safety and clinical outcome.
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653 $a Transrectal diffuse optical tomography
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