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An Examination of Cyanotoxins and En...

Braham, Ryan Patrick.

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An Examination of Cyanotoxins and Environmental Estrogens in the Middle and Upper Potomac River Watershed, USA.

Record Type:	Electronic resources : Monograph/item
Title/Author:	An Examination of Cyanotoxins and Environmental Estrogens in the Middle and Upper Potomac River Watershed, USA./
Author:	Braham, Ryan Patrick.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2018,
Description:	206 p.
Notes:	Source: Dissertations Abstracts International, Volume: 79-11, Section: B.
Contained By:	Dissertations Abstracts International79-11B.
Subject:	Natural Resource Management. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10792559
ISBN:	9780355938135

An Examination of Cyanotoxins and Environmental Estrogens in the Middle and Upper Potomac River Watershed, USA.
Braham, Ryan Patrick.

An Examination of Cyanotoxins and Environmental Estrogens in the Middle and Upper Potomac River Watershed, USA. - Ann Arbor : ProQuest Dissertations & Theses, 2018 - 206 p.

Source: Dissertations Abstracts International, Volume: 79-11, Section: B.

Thesis (Ph.D.)--West Virginia University, 2018.

This item must not be sold to any third party vendors.

The Potomac River is a large tributary of the Chesapeake Bay. Large fish die-offs were reported in the Potomac watershed (specifically the South Branch of the Potomac) in 2002 and 2005, as well as smaller episodic events in recent years which have no clear correlation to any one pathogen or contaminant. Although a variety of pathogens have been identified (such as trematodes, myxozoans, Aeromonas hydrophila, A. salmonicida, Flavobacterium columnare , and largemouth bass virus) in recent die-offs of smallmouth bass Micropterus dolomieu, no clear cause has been derived. Additionally, reproductive endpoints were reported in smallmouth bass and likely associated with instream estrogenic compounds. There has been increasing support for estrogenic compounds associated with agricultural runoff as one of the causes. However, there are little data on the contribution from primary producers such as cyanobacteria. Harmful algal blooms are of increasing concern to human health worldwide and their effects on the aquatic community within the South Branch Potomac watershed is largely unknown. To address knowledge gaps associated with fish health in the South Branch Potomac watershed, an assessment of the temporal and spatial distribution of algal toxins and environmental estrogens was required. This dissertation addresses: 1) the spatial and temporal distribution of cyanobacterial toxins in water, periphyton, and fish tissue; 2) the transcriptional response of smallmouth bass hepatocytes and leukocytes challenged with the cyanobacterial toxin microcystin-LR; 3) the spatial and temporal distribution of environmental estrogens in water and periphyton and their association with phytoestrogen presence and cyanobacterial toxins; and 4) an assessment of reporter interference in water and periphyton samples.

ISBN: 9780355938135Subjects--Topical Terms:

676989
Natural Resource Management.
Subjects--Index Terms:

Bioassay

An Examination of Cyanotoxins and Environmental Estrogens in the Middle and Upper Potomac River Watershed, USA.
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245 1 3 $a An Examination of Cyanotoxins and Environmental Estrogens in the Middle and Upper Potomac River Watershed, USA.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2018
300 $a 206 p.
500 $a Source: Dissertations Abstracts International, Volume: 79-11, Section: B.
500 $a Publisher info.: Dissertation/Thesis.
500 $a Advisor: Mazik, Patricia M.
502 $a Thesis (Ph.D.)--West Virginia University, 2018.
506 $a This item must not be sold to any third party vendors.
520 $a The Potomac River is a large tributary of the Chesapeake Bay. Large fish die-offs were reported in the Potomac watershed (specifically the South Branch of the Potomac) in 2002 and 2005, as well as smaller episodic events in recent years which have no clear correlation to any one pathogen or contaminant. Although a variety of pathogens have been identified (such as trematodes, myxozoans, Aeromonas hydrophila, A. salmonicida, Flavobacterium columnare , and largemouth bass virus) in recent die-offs of smallmouth bass Micropterus dolomieu, no clear cause has been derived. Additionally, reproductive endpoints were reported in smallmouth bass and likely associated with instream estrogenic compounds. There has been increasing support for estrogenic compounds associated with agricultural runoff as one of the causes. However, there are little data on the contribution from primary producers such as cyanobacteria. Harmful algal blooms are of increasing concern to human health worldwide and their effects on the aquatic community within the South Branch Potomac watershed is largely unknown. To address knowledge gaps associated with fish health in the South Branch Potomac watershed, an assessment of the temporal and spatial distribution of algal toxins and environmental estrogens was required. This dissertation addresses: 1) the spatial and temporal distribution of cyanobacterial toxins in water, periphyton, and fish tissue; 2) the transcriptional response of smallmouth bass hepatocytes and leukocytes challenged with the cyanobacterial toxin microcystin-LR; 3) the spatial and temporal distribution of environmental estrogens in water and periphyton and their association with phytoestrogen presence and cyanobacterial toxins; and 4) an assessment of reporter interference in water and periphyton samples.
590 $a School code: 0256.
650 4 $a Natural Resource Management. $3 676989
650 4 $a Environmental science. $3 677245
650 4 $a Aquatic sciences. $3 3174300
653 $a Bioassay
653 $a Cyanobacteria
653 $a Estrogen equivalent concentration
653 $a Interference
653 $a Microcystin
653 $a Transcript abundance
690 $a 0528
690 $a 0768
690 $a 0792
710 2 $a West Virginia University. $b Davis College of Argriculture, Natural Resources, & Design. $3 2098241
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790 $a 0256
791 $a Ph.D.
792 $a 2018
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10792559