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In Vitro Generation of Adaptive Immu...

Seet, Christopher SY.

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In Vitro Generation of Adaptive Immunity from Hematopoietic Stem Cells.

Record Type:	Electronic resources : Monograph/item
Title/Author:	In Vitro Generation of Adaptive Immunity from Hematopoietic Stem Cells./
Author:	Seet, Christopher SY.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2018,
Description:	118 p.
Notes:	Source: Dissertations Abstracts International, Volume: 79-10, Section: B.
Contained By:	Dissertations Abstracts International79-10B.
Subject:	Cellular biology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10751965
ISBN:	9780355820980

In Vitro Generation of Adaptive Immunity from Hematopoietic Stem Cells.
Seet, Christopher SY.

In Vitro Generation of Adaptive Immunity from Hematopoietic Stem Cells. - Ann Arbor : ProQuest Dissertations & Theses, 2018 - 118 p.

Source: Dissertations Abstracts International, Volume: 79-10, Section: B.

Thesis (Ph.D.)--University of California, Los Angeles, 2018.

This item is not available from ProQuest Dissertations & Theses.

The engagement of a dendritic cell with a T cell expressing a cognate T cell receptor is the defining even in the initiation of adaptive immunity against pathogens and cancer cells. The ability to understand, manipulate, and engineer T cell and dendritic cell anti-tumor immune responses is reshaping our approach to cancer therapy. This dissertation presents research exploring two parallel avenues for enhancing anti-tumor adaptive immunity through the in vitro development of T cells and cDC1 dendritic cells from human hematopoietic stem and progenitor cells. While dealing with two distantly related hematopoietic lineages and their emergence from primitive progenitor cells, the common theme uniting these projects is the opportunity to more effectively engineer adaptive immunity through an improved understanding of these earliest stages of immune cell development.

ISBN: 9780355820980Subjects--Topical Terms:

3172791
Cellular biology.
Subjects--Index Terms:

Dendritic cell

In Vitro Generation of Adaptive Immunity from Hematopoietic Stem Cells.
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100 1 $a Seet, Christopher SY. $3 3549613
245 1 0 $a In Vitro Generation of Adaptive Immunity from Hematopoietic Stem Cells.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2018
300 $a 118 p.
500 $a Source: Dissertations Abstracts International, Volume: 79-10, Section: B.
500 $a Publisher info.: Dissertation/Thesis.
500 $a Advisor: Crooks, Gay M.
502 $a Thesis (Ph.D.)--University of California, Los Angeles, 2018.
506 $a This item is not available from ProQuest Dissertations & Theses.
506 $a This item must not be added to any third party search indexes.
506 $a This item must not be sold to any third party vendors.
520 $a The engagement of a dendritic cell with a T cell expressing a cognate T cell receptor is the defining even in the initiation of adaptive immunity against pathogens and cancer cells. The ability to understand, manipulate, and engineer T cell and dendritic cell anti-tumor immune responses is reshaping our approach to cancer therapy. This dissertation presents research exploring two parallel avenues for enhancing anti-tumor adaptive immunity through the in vitro development of T cells and cDC1 dendritic cells from human hematopoietic stem and progenitor cells. While dealing with two distantly related hematopoietic lineages and their emergence from primitive progenitor cells, the common theme uniting these projects is the opportunity to more effectively engineer adaptive immunity through an improved understanding of these earliest stages of immune cell development.
590 $a School code: 0031.
650 4 $a Cellular biology. $3 3172791
650 4 $a Developmental biology. $3 592588
650 4 $a Immunology. $3 611031
653 $a Dendritic cell
653 $a Hematopoiesis
653 $a Immunotherapy
653 $a T cell
690 $a 0379
690 $a 0758
690 $a 0982
710 2 $a University of California, Los Angeles. $b Cellular and Molecular Pathology. $3 3549614
773 0 $t Dissertations Abstracts International $g 79-10B.
790 $a 0031
791 $a Ph.D.
792 $a 2018
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10751965