東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Isothiocyanates from Chorispora Tene...

Arnold, Olivia.

FindBook

Google Book

Amazon

博客來

Isothiocyanates from Chorispora Tenella and Their Toxicity to Liver and Thyroid Cell Lines.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Isothiocyanates from Chorispora Tenella and Their Toxicity to Liver and Thyroid Cell Lines./
作者:	Arnold, Olivia.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2018,
面頁冊數:	125 p.
附註:	Source: Dissertations Abstracts International, Volume: 79-12, Section: B.
Contained By:	Dissertations Abstracts International79-12B.
標題:	Toxicology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10751086
ISBN:	9780438042391

Isothiocyanates from Chorispora Tenella and Their Toxicity to Liver and Thyroid Cell Lines.
Arnold, Olivia.

Isothiocyanates from Chorispora Tenella and Their Toxicity to Liver and Thyroid Cell Lines. - Ann Arbor : ProQuest Dissertations & Theses, 2018 - 125 p.

Source: Dissertations Abstracts International, Volume: 79-12, Section: B.

Thesis (Ph.D.)--Colorado State University, 2018.

This item must not be added to any third party search indexes.

Consumption of Brassica plants like Chorispora tenella that contain isothiocyanates can be detrimental to the health of livestock, specifically horses. Late term gestational mares who ingest Brassica plants, in particular Chorispora tenella, have had foals born with Congenital Hypothyroid Dysmaturity Syndrome. Symptoms include underbite, contracted tendons, uncharacteristic silky coat, and incompletely formed hock and carpal joints. Unfortunately, most of the foals do not survive. Additionally, isothiocyanates can cause renal dysfunction, liver and thyroid toxicity. In particular, isothiocyanates have a profound antithyroid effect by interfering with the synthesis of thyroid hormones. In this study, Chorispora tenella in the Fort Collins area was quantified for isothiocyanate content in 2010, 2016 and 2017. In 2010, there were three isothiocyanates present in this Brassica plant: allyl isothiocyanate, propyl isothiocyanate and butyl isothiocyanate. However, in the 2016 and 2017 plant samples there was only allyl isothiocyanate present. Lastly, HepG2 human hepatocarcinoma and K1 human thyroid carcinoma cells were used as cytotoxicity models for the liver and thyroid pathology seen after ingestion of plants from the Brassica family. Results show that HepG2 cells were more sensitive to the various isothiocyanates and to Chorispora tenella plant extracts than the K1 cell line. These findings show that exposure to isothiocyanates and Chorispora tenella may impact livestock health even at a subclinical level and provide baseline information for further studies investigating the molecular mechanism of cytotoxicity by isothiocyanates.

ISBN: 9780438042391Subjects--Topical Terms:

556884
Toxicology.
Subjects--Index Terms:

Glucosinolate

Isothiocyanates from Chorispora Tenella and Their Toxicity to Liver and Thyroid Cell Lines.
LDR:02955nmm a2200385 4500 001 2272182
005 20201105105954.5
008 220629s2018 ||||||||||||||||| ||eng d
020 $a 9780438042391
035 $a (MiAaPQ)AAI10751086
035 $a (MiAaPQ)colostate:14713
035 $a AAI10751086
040 $a MiAaPQ $c MiAaPQ
100 1 $a Arnold, Olivia. $3 3549611
245 1 0 $a Isothiocyanates from Chorispora Tenella and Their Toxicity to Liver and Thyroid Cell Lines.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2018
300 $a 125 p.
500 $a Source: Dissertations Abstracts International, Volume: 79-12, Section: B.
500 $a Publisher info.: Dissertation/Thesis.
500 $a Advisor: Ramsdell, Howard S.
502 $a Thesis (Ph.D.)--Colorado State University, 2018.
506 $a This item must not be added to any third party search indexes.
506 $a This item must not be sold to any third party vendors.
520 $a Consumption of Brassica plants like Chorispora tenella that contain isothiocyanates can be detrimental to the health of livestock, specifically horses. Late term gestational mares who ingest Brassica plants, in particular Chorispora tenella, have had foals born with Congenital Hypothyroid Dysmaturity Syndrome. Symptoms include underbite, contracted tendons, uncharacteristic silky coat, and incompletely formed hock and carpal joints. Unfortunately, most of the foals do not survive. Additionally, isothiocyanates can cause renal dysfunction, liver and thyroid toxicity. In particular, isothiocyanates have a profound antithyroid effect by interfering with the synthesis of thyroid hormones. In this study, Chorispora tenella in the Fort Collins area was quantified for isothiocyanate content in 2010, 2016 and 2017. In 2010, there were three isothiocyanates present in this Brassica plant: allyl isothiocyanate, propyl isothiocyanate and butyl isothiocyanate. However, in the 2016 and 2017 plant samples there was only allyl isothiocyanate present. Lastly, HepG2 human hepatocarcinoma and K1 human thyroid carcinoma cells were used as cytotoxicity models for the liver and thyroid pathology seen after ingestion of plants from the Brassica family. Results show that HepG2 cells were more sensitive to the various isothiocyanates and to Chorispora tenella plant extracts than the K1 cell line. These findings show that exposure to isothiocyanates and Chorispora tenella may impact livestock health even at a subclinical level and provide baseline information for further studies investigating the molecular mechanism of cytotoxicity by isothiocyanates.
590 $a School code: 0053.
650 4 $a Toxicology. $3 556884
650 4 $a Environmental Health. $3 578282
653 $a Glucosinolate
653 $a Isothiocyanate
653 $a Liver cell line
653 $a Thyroid cell line
690 $a 0383
690 $a 0470
710 2 $a Colorado State University. $b Environmental and Radiological Health Sciences. $3 3171224
773 0 $t Dissertations Abstracts International $g 79-12B.
790 $a 0053
791 $a Ph.D.
792 $a 2018
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10751086