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Isothiocyanates from Chorispora Tene...

Arnold, Olivia.

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Isothiocyanates from Chorispora Tenella and Their Toxicity to Liver and Thyroid Cell Lines.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Isothiocyanates from Chorispora Tenella and Their Toxicity to Liver and Thyroid Cell Lines./
Author:	Arnold, Olivia.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2018,
Description:	125 p.
Notes:	Source: Dissertations Abstracts International, Volume: 79-12, Section: B.
Contained By:	Dissertations Abstracts International79-12B.
Subject:	Toxicology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10751086
ISBN:	9780438042391

Isothiocyanates from Chorispora Tenella and Their Toxicity to Liver and Thyroid Cell Lines.
Arnold, Olivia.

Isothiocyanates from Chorispora Tenella and Their Toxicity to Liver and Thyroid Cell Lines. - Ann Arbor : ProQuest Dissertations & Theses, 2018 - 125 p.

Source: Dissertations Abstracts International, Volume: 79-12, Section: B.

Thesis (Ph.D.)--Colorado State University, 2018.

This item must not be added to any third party search indexes.

Consumption of Brassica plants like Chorispora tenella that contain isothiocyanates can be detrimental to the health of livestock, specifically horses. Late term gestational mares who ingest Brassica plants, in particular Chorispora tenella, have had foals born with Congenital Hypothyroid Dysmaturity Syndrome. Symptoms include underbite, contracted tendons, uncharacteristic silky coat, and incompletely formed hock and carpal joints. Unfortunately, most of the foals do not survive. Additionally, isothiocyanates can cause renal dysfunction, liver and thyroid toxicity. In particular, isothiocyanates have a profound antithyroid effect by interfering with the synthesis of thyroid hormones. In this study, Chorispora tenella in the Fort Collins area was quantified for isothiocyanate content in 2010, 2016 and 2017. In 2010, there were three isothiocyanates present in this Brassica plant: allyl isothiocyanate, propyl isothiocyanate and butyl isothiocyanate. However, in the 2016 and 2017 plant samples there was only allyl isothiocyanate present. Lastly, HepG2 human hepatocarcinoma and K1 human thyroid carcinoma cells were used as cytotoxicity models for the liver and thyroid pathology seen after ingestion of plants from the Brassica family. Results show that HepG2 cells were more sensitive to the various isothiocyanates and to Chorispora tenella plant extracts than the K1 cell line. These findings show that exposure to isothiocyanates and Chorispora tenella may impact livestock health even at a subclinical level and provide baseline information for further studies investigating the molecular mechanism of cytotoxicity by isothiocyanates.

ISBN: 9780438042391Subjects--Topical Terms:

556884
Toxicology.
Subjects--Index Terms:

Glucosinolate

Isothiocyanates from Chorispora Tenella and Their Toxicity to Liver and Thyroid Cell Lines.
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245 1 0 $a Isothiocyanates from Chorispora Tenella and Their Toxicity to Liver and Thyroid Cell Lines.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2018
300 $a 125 p.
500 $a Source: Dissertations Abstracts International, Volume: 79-12, Section: B.
500 $a Publisher info.: Dissertation/Thesis.
500 $a Advisor: Ramsdell, Howard S.
502 $a Thesis (Ph.D.)--Colorado State University, 2018.
506 $a This item must not be added to any third party search indexes.
506 $a This item must not be sold to any third party vendors.
520 $a Consumption of Brassica plants like Chorispora tenella that contain isothiocyanates can be detrimental to the health of livestock, specifically horses. Late term gestational mares who ingest Brassica plants, in particular Chorispora tenella, have had foals born with Congenital Hypothyroid Dysmaturity Syndrome. Symptoms include underbite, contracted tendons, uncharacteristic silky coat, and incompletely formed hock and carpal joints. Unfortunately, most of the foals do not survive. Additionally, isothiocyanates can cause renal dysfunction, liver and thyroid toxicity. In particular, isothiocyanates have a profound antithyroid effect by interfering with the synthesis of thyroid hormones. In this study, Chorispora tenella in the Fort Collins area was quantified for isothiocyanate content in 2010, 2016 and 2017. In 2010, there were three isothiocyanates present in this Brassica plant: allyl isothiocyanate, propyl isothiocyanate and butyl isothiocyanate. However, in the 2016 and 2017 plant samples there was only allyl isothiocyanate present. Lastly, HepG2 human hepatocarcinoma and K1 human thyroid carcinoma cells were used as cytotoxicity models for the liver and thyroid pathology seen after ingestion of plants from the Brassica family. Results show that HepG2 cells were more sensitive to the various isothiocyanates and to Chorispora tenella plant extracts than the K1 cell line. These findings show that exposure to isothiocyanates and Chorispora tenella may impact livestock health even at a subclinical level and provide baseline information for further studies investigating the molecular mechanism of cytotoxicity by isothiocyanates.
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653 $a Glucosinolate
653 $a Isothiocyanate
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653 $a Thyroid cell line
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690 $a 0470
710 2 $a Colorado State University. $b Environmental and Radiological Health Sciences. $3 3171224
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792 $a 2018
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10751086