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Characterizing Inhibitors of the Bac...

Morgan, Jessica M.

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Characterizing Inhibitors of the Bacterial Type Three Secretion System.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Characterizing Inhibitors of the Bacterial Type Three Secretion System./
作者:	Morgan, Jessica M.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2018,
面頁冊數:	114 p.
附註:	Source: Dissertations Abstracts International, Volume: 80-05, Section: B.
Contained By:	Dissertations Abstracts International80-05B.
標題:	Microbiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10929879
ISBN:	9780438534377

Characterizing Inhibitors of the Bacterial Type Three Secretion System.
Morgan, Jessica M.

Characterizing Inhibitors of the Bacterial Type Three Secretion System. - Ann Arbor : ProQuest Dissertations & Theses, 2018 - 114 p.

Source: Dissertations Abstracts International, Volume: 80-05, Section: B.

Thesis (Ph.D.)--University of California, Santa Cruz, 2018.

This item is not available from ProQuest Dissertations & Theses.

The aims of my dissertation research were to characterize the activity of inhibitors targeting the bacterial virulence factor, the type III secretion system (T3SS). The T3SS is a needle-like apparatus used by dozens of bacterial pathogens to directly deposit bacterial effector toxins inside the cytoplasm of target host cells. This virulence factor is typically essential for bacterial survival and replication within the host, and dozens of T3SS- positive pathogens are the causative agents of relevant health threats. Importantly, these T3SSs are highly conserved between bacterial species that possess them, making them an attractive potential drug target. The first half of this work focuses on taking advantage of the tightly regulated, processional assembly and deployment of the T3SS and designing and optimizing assays we can use to probe for inhibitory activity at discreet stages throughout this process. The second goal of my dissertation research was to employ this assay to characterize an inhibitor of the T3SS, piericidin A1, and have determined the molecule inhibits T3SS needle assembly.

ISBN: 9780438534377Subjects--Topical Terms:

536250
Microbiology.
Subjects--Index Terms:

Gram-negative bacteria

Characterizing Inhibitors of the Bacterial Type Three Secretion System.
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