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Effects of Sitagliptin on Cardiovasc...

Palfrey, Henry.

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Effects of Sitagliptin on Cardiovascular Structural and Biochemical Changes in Rats Fed Atherogenic Diets.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Effects of Sitagliptin on Cardiovascular Structural and Biochemical Changes in Rats Fed Atherogenic Diets./
作者:	Palfrey, Henry.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2020,
面頁冊數:	151 p.
附註:	Source: Dissertations Abstracts International, Volume: 81-11, Section: B.
Contained By:	Dissertations Abstracts International81-11B.
標題:	Molecular biology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=27958470
ISBN:	9798641903064

Effects of Sitagliptin on Cardiovascular Structural and Biochemical Changes in Rats Fed Atherogenic Diets.
Palfrey, Henry.

Effects of Sitagliptin on Cardiovascular Structural and Biochemical Changes in Rats Fed Atherogenic Diets. - Ann Arbor : ProQuest Dissertations & Theses, 2020 - 151 p.

Source: Dissertations Abstracts International, Volume: 81-11, Section: B.

Thesis (Ph.D.)--Southern University and Agricultural and Mechanical College, 2020.

This item must not be sold to any third party vendors.

EFFECTS OF SITAGLIPTIN ON CARDIOVASCULAR STRUCTURAL AND BIOCHEMICAL CHANGES IN RATS FED ATHEROGENIC DIETSName: Palfrey, HenrySouthern University and A&M CollegeAdvisor: Dr Subramanyam N. MurthyBackground: Atherosclerosis progressing to ischemic heart disease is the most frequent cause of mortality amid many cardiovascular diseases (CVD). Western diets contribute to CVD as they are rich in the atherogenic compounds cholesterol (Cho) and methionine (Met), the latter of which forms homocysteine, a noted CVD risk factor. Since studies on the combined effects of Cho and Met are limited, the hypothesis that dietary enrichment with Cho + Met resulting in additive effects on rat cardiovascular inflammation and structural integrity was investigated. As inflammation is a cornerstone in CVD, we also tested the anti-inflammatory potential of sitagliptin, an anti-diabetic drug with multiple health benefits independent of glucose-lowering. Methods: Adult male Sprague-Dawley rats were fed either a control, high Met (1.5%), high Cho (2.0%), or high Met + high Cho diet for short- and long-term periods, of 35 and 98 days, respectively. Animals were orally gavaged with either vehicle or sitagliptin (100 mg/kg/d) from day 10 through 35 in short-term and day 30 through 98 in the long-term. At the conclusion of experiments, rats were euthanized, and cardiovascular tissue was collected for analysis. Results: Cardiac atherosclerotic markers were unaffected by diet alone in the short-term but increased by sitagliptin in rats fed the high Cho diet. Expression of the markers were attenuated by the addition of high Met to the high Cho diet. Conversely, long-term high Cho feeding increased the expression of atherosclerotic markers, independent of sitagliptin. Histopathological data of cardiac troponin-I showed marked reductions in myocardial striations in short-term high Cho feeding, which was exacerbated by sitagliptin, but improved by the addition of high Met to the high Cho diet. Similar structural alterations were observed in the long-term, independent of sitagliptin.Conclusions: Collectively, our data demonstrate that atherosclerotic responses and structural changes in rat cardiovascular tissue (seen in long term feeding of high Cho) are accelerated and exacerbated by acute sitagliptin administration. Importantly, the addition of high Met to the high Cho diet counters such effects. These findings may be important for evaluating the risk benefit of sitagliptin in type 2 diabetic patients known to consume atherogenic diets.

ISBN: 9798641903064Subjects--Topical Terms:

517296
Molecular biology.
Subjects--Index Terms:

Cardiovascular disease

Effects of Sitagliptin on Cardiovascular Structural and Biochemical Changes in Rats Fed Atherogenic Diets.
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