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Nutritional Supplementation and Skel...

Wu, Hexirui.

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Nutritional Supplementation and Skeletal Muscle Health in Chronic Diseases.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Nutritional Supplementation and Skeletal Muscle Health in Chronic Diseases./
Author:	Wu, Hexirui.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2020,
Description:	151 p.
Notes:	Source: Dissertations Abstracts International, Volume: 81-11, Section: B.
Contained By:	Dissertations Abstracts International81-11B.
Subject:	Cellular biology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=27957456
ISBN:	9798643195719

Nutritional Supplementation and Skeletal Muscle Health in Chronic Diseases.
Wu, Hexirui.

Nutritional Supplementation and Skeletal Muscle Health in Chronic Diseases. - Ann Arbor : ProQuest Dissertations & Theses, 2020 - 151 p.

Source: Dissertations Abstracts International, Volume: 81-11, Section: B.

Thesis (Ph.D.)--University of Arkansas, 2020.

This item must not be sold to any third party vendors.

Prevalence of chronic diseases in the United States keeps increasing in recent years. There are approximately four in ten adults having chronic diseases in America. Chronic diseases include obesity, aging, heart diseases, cancer and many others. This thesis mainly focuses on obesity and aging. Skeletal muscle performance is impaired in obesity and aging conditions. One common reason causing this could be higher fat mass and lower muscle mass. However, there is no study showing what pathways are involved in the imbalance of body composition. Therefore, the first objective of the thesis is to determine gene expression of selected pathways in the skeletal muscle from young and old, lean and overweight/obese participants. Leucine has been shown to activate protein translation initiation pathway mTORC1 in skeletal muscle. Further, mTORC1 is also known for regulating a variety of cellular pathways. Thus, the second objective of the thesis is to determine the effect and mechanisms of leucine supplementation on preventing intracellular lipid accumulation in skeletal muscle cells.

ISBN: 9798643195719Subjects--Topical Terms:

3172791
Cellular biology.
Subjects--Index Terms:

Chronic disease

Nutritional Supplementation and Skeletal Muscle Health in Chronic Diseases.
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245 1 0 $a Nutritional Supplementation and Skeletal Muscle Health in Chronic Diseases.
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300 $a 151 p.
500 $a Source: Dissertations Abstracts International, Volume: 81-11, Section: B.
500 $a Advisor: Baum, Jamie I.
502 $a Thesis (Ph.D.)--University of Arkansas, 2020.
506 $a This item must not be sold to any third party vendors.
520 $a Prevalence of chronic diseases in the United States keeps increasing in recent years. There are approximately four in ten adults having chronic diseases in America. Chronic diseases include obesity, aging, heart diseases, cancer and many others. This thesis mainly focuses on obesity and aging. Skeletal muscle performance is impaired in obesity and aging conditions. One common reason causing this could be higher fat mass and lower muscle mass. However, there is no study showing what pathways are involved in the imbalance of body composition. Therefore, the first objective of the thesis is to determine gene expression of selected pathways in the skeletal muscle from young and old, lean and overweight/obese participants. Leucine has been shown to activate protein translation initiation pathway mTORC1 in skeletal muscle. Further, mTORC1 is also known for regulating a variety of cellular pathways. Thus, the second objective of the thesis is to determine the effect and mechanisms of leucine supplementation on preventing intracellular lipid accumulation in skeletal muscle cells.
590 $a School code: 0011.
650 4 $a Cellular biology. $3 3172791
650 4 $a Molecular biology. $3 517296
650 4 $a Nutrition. $3 517777
653 $a Chronic disease
653 $a Leucine
653 $a Obesity
653 $a Sarcipenia
653 $a Skeletal muscle
690 $a 0379
690 $a 0307
690 $a 0570
710 2 $a University of Arkansas. $b Food Science. $3 3282884
773 0 $t Dissertations Abstracts International $g 81-11B.
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792 $a 2020
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