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Human papillomavirus and cervical ne...

Liaw, Kai-Li.

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Human papillomavirus and cervical neoplasia: A community-based case-control study in Taiwan.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Human papillomavirus and cervical neoplasia: A community-based case-control study in Taiwan./
Author:	Liaw, Kai-Li.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 1995,
Description:	208 p.
Notes:	Source: Dissertations Abstracts International, Volume: 57-03, Section: B.
Contained By:	Dissertations Abstracts International57-03B.
Subject:	Public health. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9533285

Human papillomavirus and cervical neoplasia: A community-based case-control study in Taiwan.
Liaw, Kai-Li.

Human papillomavirus and cervical neoplasia: A community-based case-control study in Taiwan. - Ann Arbor : ProQuest Dissertations & Theses, 1995 - 208 p.

Source: Dissertations Abstracts International, Volume: 57-03, Section: B.

Thesis (Ph.D.)--The Johns Hopkins University, 1995.

This item must not be sold to any third party vendors.

Background. Taiwan is a high-risk area for cervical cancer, with an annual age-adjusted incidence rate of 33.5 per 100,000. Human papillomavirus (HPV), the major risk factor for cervical cancer in western countries, is frequently detected in cervical cancer patients in Taiwan (over 70%), although its prevalence in Taiwan's general population is unknown. However, the reported prevalence of other risk factors, in particular multiple sexual partners, is very low. Purpose. To conduct a case-control study to evaluate the role of HPV, a sexually transmitted agent, and other risk factors in the etiology of cervical neoplasia in Taiwan. Methods. As part of a large-scale, community-based cervical neoplasia screening project in rural Taiwan, a case-control study was undertaken. Among 5,286 screening participants, 88 biopsy-confirmed cases and 261 cytologically normal controls were selected for the study. The case group included 40 cases of cervical intraepithelial neoplasia (CIN) 1, 9 of CIN 2, 36 of CIN 3, and 3 cases of invasive cancer. Cervical swabs collected at screening from study subjects were tested for HPV DNA by an L1 consensus primer polymerase chain reaction (PCR)-based technique. Results. HPV was significantly associated with both high-grade (odds ratio (OR) = 122.3, 95% confidence interval (CI) 38.5-388.9) and low-grade (OR = 14.0, 95% CI 6.1-32.0) cervical neoplasia. As reported in western countries, HPV 16 was the predominant type among HPV-positive high-grade cases (48%). However, HPV 52 and 58 were the most common types among HPV-positive low-grade cases (25%) and controls (38%). Overall, 91% of high-grade cases and 50% of low-grade cases could be attributed to HPV infection in this population. After adjustment for HPV, a non-significantly higher risk of cervical neoplasia was observed in women who reported that their male partner had sometimes/often visited prostitutes (OR = 2.1, 95% CI 0.3-12.7 for high-grade and OR = 4.9, 95% CI 0.7-34.8 for low-grade cervical neoplasia). No appreciable higher risk was found associated with other risk factors. Conclusion. In this monogamous population in Taiwan, HPV is a major risk factor for cervical neoplasia. In addition, sexual practices of the male partners of these monogamous women is weakly associated with cervical neoplasia, suggesting that male factors, in particular sexual practices, may play a role in the etiology of cervical neoplasia.Subjects--Topical Terms:

534748
Public health.
Subjects--Index Terms:

China

Human papillomavirus and cervical neoplasia: A community-based case-control study in Taiwan.
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245 1 0 $a Human papillomavirus and cervical neoplasia: A community-based case-control study in Taiwan.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 1995
300 $a 208 p.
500 $a Source: Dissertations Abstracts International, Volume: 57-03, Section: B.
500 $a Publisher info.: Dissertation/Thesis.
502 $a Thesis (Ph.D.)--The Johns Hopkins University, 1995.
506 $a This item must not be sold to any third party vendors.
506 $a This item must not be added to any third party search indexes.
520 $a Background. Taiwan is a high-risk area for cervical cancer, with an annual age-adjusted incidence rate of 33.5 per 100,000. Human papillomavirus (HPV), the major risk factor for cervical cancer in western countries, is frequently detected in cervical cancer patients in Taiwan (over 70%), although its prevalence in Taiwan's general population is unknown. However, the reported prevalence of other risk factors, in particular multiple sexual partners, is very low. Purpose. To conduct a case-control study to evaluate the role of HPV, a sexually transmitted agent, and other risk factors in the etiology of cervical neoplasia in Taiwan. Methods. As part of a large-scale, community-based cervical neoplasia screening project in rural Taiwan, a case-control study was undertaken. Among 5,286 screening participants, 88 biopsy-confirmed cases and 261 cytologically normal controls were selected for the study. The case group included 40 cases of cervical intraepithelial neoplasia (CIN) 1, 9 of CIN 2, 36 of CIN 3, and 3 cases of invasive cancer. Cervical swabs collected at screening from study subjects were tested for HPV DNA by an L1 consensus primer polymerase chain reaction (PCR)-based technique. Results. HPV was significantly associated with both high-grade (odds ratio (OR) = 122.3, 95% confidence interval (CI) 38.5-388.9) and low-grade (OR = 14.0, 95% CI 6.1-32.0) cervical neoplasia. As reported in western countries, HPV 16 was the predominant type among HPV-positive high-grade cases (48%). However, HPV 52 and 58 were the most common types among HPV-positive low-grade cases (25%) and controls (38%). Overall, 91% of high-grade cases and 50% of low-grade cases could be attributed to HPV infection in this population. After adjustment for HPV, a non-significantly higher risk of cervical neoplasia was observed in women who reported that their male partner had sometimes/often visited prostitutes (OR = 2.1, 95% CI 0.3-12.7 for high-grade and OR = 4.9, 95% CI 0.7-34.8 for low-grade cervical neoplasia). No appreciable higher risk was found associated with other risk factors. Conclusion. In this monogamous population in Taiwan, HPV is a major risk factor for cervical neoplasia. In addition, sexual practices of the male partners of these monogamous women is weakly associated with cervical neoplasia, suggesting that male factors, in particular sexual practices, may play a role in the etiology of cervical neoplasia.
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