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Route to a Highly Selective and Sens...

Moustakas, Holger.

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Route to a Highly Selective and Sensitive Molecular Imprinted Polymer Sensor for Isatin.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Route to a Highly Selective and Sensitive Molecular Imprinted Polymer Sensor for Isatin./
Author:	Moustakas, Holger.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2019,
Description:	165 p.
Notes:	Source: Dissertations Abstracts International, Volume: 81-05, Section: B.
Contained By:	Dissertations Abstracts International81-05B.
Subject:	Polymer chemistry. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=27543167
ISBN:	9781392414194

Route to a Highly Selective and Sensitive Molecular Imprinted Polymer Sensor for Isatin.
Moustakas, Holger.

Route to a Highly Selective and Sensitive Molecular Imprinted Polymer Sensor for Isatin. - Ann Arbor : ProQuest Dissertations & Theses, 2019 - 165 p.

Source: Dissertations Abstracts International, Volume: 81-05, Section: B.

Thesis (Ph.D.)--Dartmouth College, 2019.

This item must not be sold to any third party vendors.

This work discusses the fabrication of a molecularly imprinted polymer (MIP) sensor for isatin, which can be used for quantification of stress in humans and for early detection of illness. The first part of this work covers the synthesis of the conductive element of these materials. Various synthetic routes and parameters for the synthesis of polyaniline nanofibers were investigated. It was shown that contrary to the published literature, the interfacial synthetic method produced polyaniline without nanofibrous morphology, while the rapid addition synthesis produced robust nanofibrous morphology. The variables were systematically examined to determine the optimal conditions for the production of nanofibers. Hydrochloric acid was shown to be the most favorable reaction catalyst/doping agent, resulting in the most well-defined nanofibers. The morphology of the nanofibers was influenced by the dialysis conditions. It was shown that 1 hr dialysis in H2O provided the optimal morphology and polymer resistance. The nanofiber production was found to be complete in thirty minutes at a reaction temperature of 35 °C. The second part of this work covers the fabrication of a MIP for isatin. It was shown that the phase-inversion thin film fabrication technique was not able to produce stable cavities in the MIP, as reinsertion was not observed. A full synthesis to fabricate a MIP for isatin was then investigated so that the polymer could be cross-linked and stabilize the cavities. Isatin imprinted MIPs were shown to strongly trap isatin, preventing extraction of the template. Indoline, with structural similarities to isatin, was used as a substitute template molecule. Through optimization of the synthetic conditions and reinsertion procedure, indoline templated MIPs were shown to bind isatin. Selectivity tests with 5-methylisatin and nicotine were performed with the MIP demonstrating selectivity against these targets. Finally, the MIP for isatin and the optimized polyaniline nanofibers were combined to fabricate a chemiresistive sensor. The sensor was shown to change in resistance when exposed to isatin, albeit inconsistently. Further optimization can tune this and allow for quantitative detection.

ISBN: 9781392414194Subjects--Topical Terms:

3173488
Polymer chemistry.
Subjects--Index Terms:

Chemiresistor

Route to a Highly Selective and Sensitive Molecular Imprinted Polymer Sensor for Isatin.
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245 1 0 $a Route to a Highly Selective and Sensitive Molecular Imprinted Polymer Sensor for Isatin.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2019
300 $a 165 p.
500 $a Source: Dissertations Abstracts International, Volume: 81-05, Section: B.
500 $a Advisor: BelBruno, Joseph J.
502 $a Thesis (Ph.D.)--Dartmouth College, 2019.
506 $a This item must not be sold to any third party vendors.
520 $a This work discusses the fabrication of a molecularly imprinted polymer (MIP) sensor for isatin, which can be used for quantification of stress in humans and for early detection of illness. The first part of this work covers the synthesis of the conductive element of these materials. Various synthetic routes and parameters for the synthesis of polyaniline nanofibers were investigated. It was shown that contrary to the published literature, the interfacial synthetic method produced polyaniline without nanofibrous morphology, while the rapid addition synthesis produced robust nanofibrous morphology. The variables were systematically examined to determine the optimal conditions for the production of nanofibers. Hydrochloric acid was shown to be the most favorable reaction catalyst/doping agent, resulting in the most well-defined nanofibers. The morphology of the nanofibers was influenced by the dialysis conditions. It was shown that 1 hr dialysis in H2O provided the optimal morphology and polymer resistance. The nanofiber production was found to be complete in thirty minutes at a reaction temperature of 35 °C. The second part of this work covers the fabrication of a MIP for isatin. It was shown that the phase-inversion thin film fabrication technique was not able to produce stable cavities in the MIP, as reinsertion was not observed. A full synthesis to fabricate a MIP for isatin was then investigated so that the polymer could be cross-linked and stabilize the cavities. Isatin imprinted MIPs were shown to strongly trap isatin, preventing extraction of the template. Indoline, with structural similarities to isatin, was used as a substitute template molecule. Through optimization of the synthetic conditions and reinsertion procedure, indoline templated MIPs were shown to bind isatin. Selectivity tests with 5-methylisatin and nicotine were performed with the MIP demonstrating selectivity against these targets. Finally, the MIP for isatin and the optimized polyaniline nanofibers were combined to fabricate a chemiresistive sensor. The sensor was shown to change in resistance when exposed to isatin, albeit inconsistently. Further optimization can tune this and allow for quantitative detection.
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653 $a Molecularly imprinted polymer
653 $a Polyaniline
653 $a Sensor
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773 0 $t Dissertations Abstracts International $g 81-05B.
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793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=27543167