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Transillumination Techniques in Opht...

Weber, Timothy D.

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Transillumination Techniques in Ophthalmic Imaging.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Transillumination Techniques in Ophthalmic Imaging./
Author:	Weber, Timothy D.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2020,
Description:	146 p.
Notes:	Source: Dissertations Abstracts International, Volume: 81-11, Section: B.
Contained By:	Dissertations Abstracts International81-11B.
Subject:	Biomedical engineering. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=27955367
ISBN:	9798645447069

Transillumination Techniques in Ophthalmic Imaging.
Weber, Timothy D.

Transillumination Techniques in Ophthalmic Imaging. - Ann Arbor : ProQuest Dissertations & Theses, 2020 - 146 p.

Source: Dissertations Abstracts International, Volume: 81-11, Section: B.

Thesis (Ph.D.)--Boston University, 2020.

This item must not be sold to any third party vendors.

In vivo imaging of the human cornea and retina is typically performed in a reflection geometry. Images are formed from light that has backscattered off corneal microstructures or backreflected from the retina. In this configuration, artifacts caused by superficial surface reflections are often encountered. These unwanted reflections can either globally overwhelm the signal or cause local glare, complicating reliable image quantification. This thesis describes a pair of alternative ophthalmic imaging techniques based instead on transmitted light, which inherently avoids these artifacts. For retinal (i.e. fundus) imaging, we describe a mesoscopic transmission imaging method, which we call transcranial fundus imaging. The method uses deeply penetrating near-infrared light delivered transcranially from the side of the head, and exploits multiple scattering to redirect a portion of the light towards the posterior eye. This unique transmission geometry simplifies absorption measurements and enables flash-free, non-mydriatic imaging as deep as the choroid. We use multispectral image sets taken with this new transillumination approach to estimate oxygen saturation in retinal blood vessels.In the cornea, we describe a new technique for non-contact phase-contrast microscopic imaging. It is based on fundus retro-reflection and back-illumination of the crystalline lens and cornea. To enhance phase-gradient contrast, we apply asymmetric illumination by illuminating one side of the fundus. The technique produces micron-scale lateral resolution across a 1-mm diagonal field of view. We show representative images of the epithelium, the subbasal nerve plexus, large stromal nerves, dendritic immune cells, endothelial nuclei, and the anterior crystalline lens, demonstrating the potential of this instrument for clinical applications.

ISBN: 9798645447069Subjects--Topical Terms:

535387
Biomedical engineering.
Subjects--Index Terms:

Transillumination techniques

Transillumination Techniques in Ophthalmic Imaging.
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245 1 0 $a Transillumination Techniques in Ophthalmic Imaging.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2020
300 $a 146 p.
500 $a Source: Dissertations Abstracts International, Volume: 81-11, Section: B.
500 $a Advisor: Mertz, Jerome.
502 $a Thesis (Ph.D.)--Boston University, 2020.
506 $a This item must not be sold to any third party vendors.
520 $a In vivo imaging of the human cornea and retina is typically performed in a reflection geometry. Images are formed from light that has backscattered off corneal microstructures or backreflected from the retina. In this configuration, artifacts caused by superficial surface reflections are often encountered. These unwanted reflections can either globally overwhelm the signal or cause local glare, complicating reliable image quantification. This thesis describes a pair of alternative ophthalmic imaging techniques based instead on transmitted light, which inherently avoids these artifacts. For retinal (i.e. fundus) imaging, we describe a mesoscopic transmission imaging method, which we call transcranial fundus imaging. The method uses deeply penetrating near-infrared light delivered transcranially from the side of the head, and exploits multiple scattering to redirect a portion of the light towards the posterior eye. This unique transmission geometry simplifies absorption measurements and enables flash-free, non-mydriatic imaging as deep as the choroid. We use multispectral image sets taken with this new transillumination approach to estimate oxygen saturation in retinal blood vessels.In the cornea, we describe a new technique for non-contact phase-contrast microscopic imaging. It is based on fundus retro-reflection and back-illumination of the crystalline lens and cornea. To enhance phase-gradient contrast, we apply asymmetric illumination by illuminating one side of the fundus. The technique produces micron-scale lateral resolution across a 1-mm diagonal field of view. We show representative images of the epithelium, the subbasal nerve plexus, large stromal nerves, dendritic immune cells, endothelial nuclei, and the anterior crystalline lens, demonstrating the potential of this instrument for clinical applications.
590 $a School code: 0017.
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650 4 $a Ophthalmology. $3 862704
650 4 $a Optics. $3 517925
653 $a Transillumination techniques
653 $a Ophthalmic imaging
653 $a Reflection geometry
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793 $a English
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