東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Understanding the Molecular Pathogen...

Lin, Jonathan Beaux.

Linked to FindBook

Google Book

Amazon

博客來

Understanding the Molecular Pathogenesis of Retinal Neurodegeneration.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Understanding the Molecular Pathogenesis of Retinal Neurodegeneration./
Author:	Lin, Jonathan Beaux.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2020,
Description:	166 p.
Notes:	Source: Dissertations Abstracts International, Volume: 81-10, Section: B.
Contained By:	Dissertations Abstracts International81-10B.
Subject:	Ophthalmology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=27836096
ISBN:	9798607321246

Understanding the Molecular Pathogenesis of Retinal Neurodegeneration.
Lin, Jonathan Beaux.

Understanding the Molecular Pathogenesis of Retinal Neurodegeneration. - Ann Arbor : ProQuest Dissertations & Theses, 2020 - 166 p.

Source: Dissertations Abstracts International, Volume: 81-10, Section: B.

Thesis (Ph.D.)--Washington University in St. Louis, 2020.

This item must not be sold to any third party vendors.

Retinal degenerative diseases are a major cause of morbidity in modern society because visual impairment significantly decreases the quality of life of patients. A significant challenge in treating retinal degenerative diseases is their genetic and phenotypic heterogeneity. Furthermore, limitations in our understanding of disease pathophysiology have led to reliance on therapies that often treat disease endpoints rather than addressing disease etiology and/or pathophysiology. The long-term goal of my thesis research was to provide molecular and cellular insights into the pathophysiology underlying diverse retinal degenerative diseases, which may lead to much-needed, novel therapeutic approaches. During the first part of my thesis research, I discovered that impaired NAD+ homeostasis is a central feature of diverse retinal degenerative diseases (Chapter 2). For the second part of my thesis research, I found that the central cellular phenotype of aged macrophages, which are known to promote age-related macular degeneration, is impaired cholesterol homeostasis (Chapter 3) and that the transition towards this disease-promoting, aged phenotype is regulated, in part, by microRNA-150 (Chapter 4). Although further research is necessary to translate these findings to the bedside, they have the potential to transform care for patients with retinal degenerative diseases.

ISBN: 9798607321246Subjects--Topical Terms:

862704
Ophthalmology.
Subjects--Index Terms:

Retinal degenerative diseases

Understanding the Molecular Pathogenesis of Retinal Neurodegeneration.
LDR:02410nmm a2200313 4500 001 2269576
005 20200911122847.5
008 220629s2020 ||||||||||||||||| ||eng d
020 $a 9798607321246
035 $a (MiAaPQ)AAI27836096
035 $a AAI27836096
040 $a MiAaPQ $c MiAaPQ
100 1 $a Lin, Jonathan Beaux. $3 3546913
245 1 0 $a Understanding the Molecular Pathogenesis of Retinal Neurodegeneration.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2020
300 $a 166 p.
500 $a Source: Dissertations Abstracts International, Volume: 81-10, Section: B.
500 $a Advisor: Apte, Rajendra.
502 $a Thesis (Ph.D.)--Washington University in St. Louis, 2020.
506 $a This item must not be sold to any third party vendors.
520 $a Retinal degenerative diseases are a major cause of morbidity in modern society because visual impairment significantly decreases the quality of life of patients. A significant challenge in treating retinal degenerative diseases is their genetic and phenotypic heterogeneity. Furthermore, limitations in our understanding of disease pathophysiology have led to reliance on therapies that often treat disease endpoints rather than addressing disease etiology and/or pathophysiology. The long-term goal of my thesis research was to provide molecular and cellular insights into the pathophysiology underlying diverse retinal degenerative diseases, which may lead to much-needed, novel therapeutic approaches. During the first part of my thesis research, I discovered that impaired NAD+ homeostasis is a central feature of diverse retinal degenerative diseases (Chapter 2). For the second part of my thesis research, I found that the central cellular phenotype of aged macrophages, which are known to promote age-related macular degeneration, is impaired cholesterol homeostasis (Chapter 3) and that the transition towards this disease-promoting, aged phenotype is regulated, in part, by microRNA-150 (Chapter 4). Although further research is necessary to translate these findings to the bedside, they have the potential to transform care for patients with retinal degenerative diseases.
590 $a School code: 0252.
650 4 $a Ophthalmology. $3 862704
650 4 $a Neurosciences. $3 588700
653 $a Retinal degenerative diseases
690 $a 0381
690 $a 0317
710 2 $a Washington University in St. Louis. $b Biology & Biomedical Sciences (Neurosciences). $3 2103470
773 0 $t Dissertations Abstracts International $g 81-10B.
790 $a 0252
791 $a Ph.D.
792 $a 2020
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=27836096