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Ionic Liquid Formation and Character...

Fiandaca, Maggie.

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Ionic Liquid Formation and Characterization of a Non-steroid Anti-inflammatory Drug.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Ionic Liquid Formation and Characterization of a Non-steroid Anti-inflammatory Drug./
Author:	Fiandaca, Maggie.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2020,
Description:	162 p.
Notes:	Source: Dissertations Abstracts International, Volume: 81-04, Section: B.
Contained By:	Dissertations Abstracts International81-04B.
Subject:	Pharmaceutical sciences. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=22620871
ISBN:	9781687920393

Ionic Liquid Formation and Characterization of a Non-steroid Anti-inflammatory Drug.
Fiandaca, Maggie.

Ionic Liquid Formation and Characterization of a Non-steroid Anti-inflammatory Drug. - Ann Arbor : ProQuest Dissertations & Theses, 2020 - 162 p.

Source: Dissertations Abstracts International, Volume: 81-04, Section: B.

Thesis (Ph.D.)--University of the Sciences in Philadelphia, 2020.

This item must not be sold to any third party vendors.

The present work focuses on modifying a non-steroid anti-inflammatory drug (NSAID) into an ionic liquid and evaluating the resulting thermal behavior and structural changes of the drug. Naproxen was chosen as the NSAID molecule due to thermal stability and limited examples of its use as an ionic liquid in current literature. Lidocaine was chosen as the counterion based on a screening study of potential ionic liquid formers. The screening included both potential protic and aprotic formation and counterions were included with consideration to pKa, hydrogen bonding ability, molecular size, diffuse charge distribution and functional groups. Analytical techniques used to evaluate the counterions included high performance liquid chromatography (HPLC), differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). Naproxen and lidocaine were then combined in varying molar ratios to determine the thermal behavior of the mixtures. The samples with equimolar, or higher, ratio of naproxen showed a phase which had a melting point of 82-85 °C. The DSC data was analyzed using a modified Tamman plot, resulting in the unexpected and previously unreported behavior of ionic liquid formation at a 2:1 molar ratio of naproxen to lidocaine, referred to as IL1 in this research. This stoichiometry was confirmed through Fourier Transformed Infrared (FT-IR) and nuclear magnetic resonance (NMR) spectroscopy methods. The samples that contained a higher molar ratio of lidocaine than naproxen, resulted in material more consistent with higher-order complex clusters. Further characterization of IL1 found that the material demonstrated behaviors of an ionic liquid, including weak intermolecular forces and at least partial ionization of the drug and counterion.

ISBN: 9781687920393Subjects--Topical Terms:

3173021
Pharmaceutical sciences.
Subjects--Index Terms:

Ionic liquid formation

Ionic Liquid Formation and Characterization of a Non-steroid Anti-inflammatory Drug.
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100 1 $a Fiandaca, Maggie. $3 3546615
245 1 0 $a Ionic Liquid Formation and Characterization of a Non-steroid Anti-inflammatory Drug.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2020
300 $a 162 p.
500 $a Source: Dissertations Abstracts International, Volume: 81-04, Section: B.
500 $a Advisor: Gupta, Pardeep K.
502 $a Thesis (Ph.D.)--University of the Sciences in Philadelphia, 2020.
506 $a This item must not be sold to any third party vendors.
520 $a The present work focuses on modifying a non-steroid anti-inflammatory drug (NSAID) into an ionic liquid and evaluating the resulting thermal behavior and structural changes of the drug. Naproxen was chosen as the NSAID molecule due to thermal stability and limited examples of its use as an ionic liquid in current literature. Lidocaine was chosen as the counterion based on a screening study of potential ionic liquid formers. The screening included both potential protic and aprotic formation and counterions were included with consideration to pKa, hydrogen bonding ability, molecular size, diffuse charge distribution and functional groups. Analytical techniques used to evaluate the counterions included high performance liquid chromatography (HPLC), differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). Naproxen and lidocaine were then combined in varying molar ratios to determine the thermal behavior of the mixtures. The samples with equimolar, or higher, ratio of naproxen showed a phase which had a melting point of 82-85 °C. The DSC data was analyzed using a modified Tamman plot, resulting in the unexpected and previously unreported behavior of ionic liquid formation at a 2:1 molar ratio of naproxen to lidocaine, referred to as IL1 in this research. This stoichiometry was confirmed through Fourier Transformed Infrared (FT-IR) and nuclear magnetic resonance (NMR) spectroscopy methods. The samples that contained a higher molar ratio of lidocaine than naproxen, resulted in material more consistent with higher-order complex clusters. Further characterization of IL1 found that the material demonstrated behaviors of an ionic liquid, including weak intermolecular forces and at least partial ionization of the drug and counterion.
590 $a School code: 1379.
650 4 $a Pharmaceutical sciences. $3 3173021
653 $a Ionic liquid formation
653 $a Non-steroid anti-inflammatory drug
690 $a 0572
710 2 $a University of the Sciences in Philadelphia. $b Pharmaceutics. $3 3546616
773 0 $t Dissertations Abstracts International $g 81-04B.
790 $a 1379
791 $a Ph.D.
792 $a 2020
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=22620871