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Characterisation and design of ultra...

University of London, University College London (United Kingdom)., Department of Mechanical Engineering.

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Characterisation and design of ultrasound agent particles.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Characterisation and design of ultrasound agent particles./
作者:	Stride, Eleanor Phoebe Jane.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2005,
面頁冊數:	363 p.
附註:	Source: Dissertations Abstracts International, Volume: 75-08, Section: C.
Contained By:	Dissertations Abstracts International75-08C.
標題:	Medical imaging. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=U602760
ISBN:	9781303760143

Characterisation and design of ultrasound agent particles.
Stride, Eleanor Phoebe Jane.

Characterisation and design of ultrasound agent particles. - Ann Arbor : ProQuest Dissertations & Theses, 2005 - 363 p.

Source: Dissertations Abstracts International, Volume: 75-08, Section: C.

Thesis (Ph.D.)--University of London, University College London (United Kingdom), 2005.

Ultrasound contrast agents, consisting of gas bubbles coated with a surfactant or polymer shell, offer benefits in a range of diagnostic and therapeutic applications. However, their behaviour both in vitro and in vivo is by no means fully understood and there remains considerable scope for increasing their effectiveness. The aim of the work described in this thesis is to improve the characterisation of existing contrast agents and to determine how future agents might be designed in order to optimise their performance. Previous theoretical and experimental work relating to both contrast agents and free gas bubbles will be reviewed. This will be followed by an assessment of the validity of the assumptions underlying existing models for contrast agents. In particular, examination will be made of: the modelling of the material coating the contrast agent particles (CAPs), the influence of blood cells upon CAP dynamics and multiple scattering of ultrasound in CAP suspensions. The results from a combination of computer simulations and experimental testing will be used to derive a new, generalised model for CAP behaviour. The model will be used to carry out a sensitivity analysis in order to identify the most significant factors controlling CAP behaviour. Based on these findings, a number of new designs will be developed, with the aim of enhancing CAP detectability at low insonation pressures. The designs will be evaluated in terms of their performance, based on the results of experiments using scale models. Finally, an assessment of the areas for future work will be made.

ISBN: 9781303760143Subjects--Topical Terms:

3172799
Medical imaging.
Subjects--Index Terms:

Contrast agents

Characterisation and design of ultrasound agent particles.
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