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Numerical modeling of ultrasound con...

Patil, Abhay Vijay.

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Numerical modeling of ultrasound contrast agents and their application to molecular imaging for guiding drug delivery.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Numerical modeling of ultrasound contrast agents and their application to molecular imaging for guiding drug delivery./
Author:	Patil, Abhay Vijay.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2010,
Description:	154 p.
Notes:	Source: Dissertations Abstracts International, Volume: 72-10, Section: B.
Contained By:	Dissertations Abstracts International72-10B.
Subject:	Biomedical engineering. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3442327
ISBN:	9781124462271

Numerical modeling of ultrasound contrast agents and their application to molecular imaging for guiding drug delivery.
Patil, Abhay Vijay.

Numerical modeling of ultrasound contrast agents and their application to molecular imaging for guiding drug delivery. - Ann Arbor : ProQuest Dissertations & Theses, 2010 - 154 p.

Source: Dissertations Abstracts International, Volume: 72-10, Section: B.

Thesis (Ph.D.)--University of Virginia, 2010.

This item must not be sold to any third party vendors.

Atherosclerosis is a progressive occlusive disease of the arterial vessels. A sensitive molecular imaging technique that can identify the early markers of atherosclerosis may assist clinicians in determining the presence or extent of the disease and in later stages this approach may also help in assessing the future risk of the disease progression. In my dissertation, I propose an ultrasound based quantitative technique that can effectively guide flowing targeted microbubbles and selectively image static microbubbles. This approach may also provide interventional guidance in mediating local drug delivery. Phenomena such as microbubble-microbubble interaction and microbubble-cell interactions are poorly understood. A thorough understanding of these phenomena can aid in selectively guiding, imaging and destroying adherent microbubbles, thus enhancing local drug delivery. I propose and validate a non-linear 3D finite element analysis (FEA) model for quantifying microbubble dynamics. This model estimates the coupled 3D oscillatory-translational motion, microbubble shell stress/strain, and backscattered acoustic pressure. The results from this model are validated against the published experimental data. This model has great potential in addressing complex problems such as analyzing the 3D asymmetric modes of vibration and in providing complementary information in the form of shell stress and strain. This detail of information is not available from conventional 1D models.

ISBN: 9781124462271Subjects--Topical Terms:

535387
Biomedical engineering.
Subjects--Index Terms:

Contrast agents

Numerical modeling of ultrasound contrast agents and their application to molecular imaging for guiding drug delivery.
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100 1 $a Patil, Abhay Vijay. $3 3546412
245 1 0 $a Numerical modeling of ultrasound contrast agents and their application to molecular imaging for guiding drug delivery.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2010
300 $a 154 p.
500 $a Source: Dissertations Abstracts International, Volume: 72-10, Section: B.
500 $a Publisher info.: Dissertation/Thesis.
500 $a Advisor: Hossack, John A.
502 $a Thesis (Ph.D.)--University of Virginia, 2010.
506 $a This item must not be sold to any third party vendors.
506 $a This item must not be added to any third party search indexes.
520 $a Atherosclerosis is a progressive occlusive disease of the arterial vessels. A sensitive molecular imaging technique that can identify the early markers of atherosclerosis may assist clinicians in determining the presence or extent of the disease and in later stages this approach may also help in assessing the future risk of the disease progression. In my dissertation, I propose an ultrasound based quantitative technique that can effectively guide flowing targeted microbubbles and selectively image static microbubbles. This approach may also provide interventional guidance in mediating local drug delivery. Phenomena such as microbubble-microbubble interaction and microbubble-cell interactions are poorly understood. A thorough understanding of these phenomena can aid in selectively guiding, imaging and destroying adherent microbubbles, thus enhancing local drug delivery. I propose and validate a non-linear 3D finite element analysis (FEA) model for quantifying microbubble dynamics. This model estimates the coupled 3D oscillatory-translational motion, microbubble shell stress/strain, and backscattered acoustic pressure. The results from this model are validated against the published experimental data. This model has great potential in addressing complex problems such as analyzing the 3D asymmetric modes of vibration and in providing complementary information in the form of shell stress and strain. This detail of information is not available from conventional 1D models.
590 $a School code: 0246.
650 4 $a Biomedical engineering. $3 535387
650 4 $a Electrical engineering. $3 649834
650 4 $a Medical imaging. $3 3172799
650 4 $a Biophysics. $3 518360
653 $a Contrast agents
653 $a Drug delivery
653 $a Elasticity imaging
653 $a Molecular imaging
653 $a Ultrasound imaging
690 $a 0541
690 $a 0544
690 $a 0574
690 $a 0760
710 2 $a University of Virginia. $3 645578
773 0 $t Dissertations Abstracts International $g 72-10B.
790 $a 0246
791 $a Ph.D.
792 $a 2010
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3442327