東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Ultrasound-mediated Microbubble Drug...

Mintsopoulos, Victoria.

Linked to FindBook

Google Book

Amazon

博客來

Ultrasound-mediated Microbubble Drug Delivery to the Injured Lung in Acute Respiratory Distress Syndrome.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Ultrasound-mediated Microbubble Drug Delivery to the Injured Lung in Acute Respiratory Distress Syndrome./
Author:	Mintsopoulos, Victoria.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2019,
Description:	156 p.
Notes:	Source: Masters Abstracts International, Volume: 81-06.
Contained By:	Masters Abstracts International81-06.
Subject:	Medicine. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=13902741
ISBN:	9781392575369

Ultrasound-mediated Microbubble Drug Delivery to the Injured Lung in Acute Respiratory Distress Syndrome.
Mintsopoulos, Victoria.

Ultrasound-mediated Microbubble Drug Delivery to the Injured Lung in Acute Respiratory Distress Syndrome. - Ann Arbor : ProQuest Dissertations & Theses, 2019 - 156 p.

Source: Masters Abstracts International, Volume: 81-06.

Thesis (M.Sc.)--University of Toronto (Canada), 2019.

This item must not be sold to any third party vendors.

Acute respiratory distress syndrome (ARDS) is a common diagnosis in ICUs and has a mortality rate approaching 40%. This disease is characterized by a build-up of fluid in the alveolar sacs. Most patients exhibit heterogeneous injury, with relatively normal-appearing areas abutting densely consolidated regions. This heterogeneity makes treatment difficult. Ultrasound-destruction of microbubbles (USMB) has been demonstrated to increase drug uptake by tissues but has never been attempted in the lung. We hypothesized that USMB would only increase drug uptake in edematous lung regions, since air scatters ultrasound waves. USMB increased the deposition and efficacy of low dose gentamicin in the lungs of an E. coli-induced ARDS mouse model. Further, we validated the use of USMB drug delivery to the injured lung in a porcine pneumonia model, suggesting feasibility in humans. USMB may therefore allow for targeted delivery of therapies - antibiotics, antivirals, genes - to the injured lung in ARDS.

ISBN: 9781392575369Subjects--Topical Terms:

641104
Medicine.
Subjects--Index Terms:

Aminoglycoside

Ultrasound-mediated Microbubble Drug Delivery to the Injured Lung in Acute Respiratory Distress Syndrome.
LDR:02169nmm a2200385 4500 001 2269049
005 20200908082318.5
008 220629s2019 ||||||||||||||||| ||eng d
020 $a 9781392575369
035 $a (MiAaPQ)AAI13902741
035 $a AAI13902741
040 $a MiAaPQ $c MiAaPQ
100 1 $a Mintsopoulos, Victoria. $3 3546353
245 1 0 $a Ultrasound-mediated Microbubble Drug Delivery to the Injured Lung in Acute Respiratory Distress Syndrome.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2019
300 $a 156 p.
500 $a Source: Masters Abstracts International, Volume: 81-06.
500 $a Advisor: Lee, Warren L.
502 $a Thesis (M.Sc.)--University of Toronto (Canada), 2019.
506 $a This item must not be sold to any third party vendors.
520 $a Acute respiratory distress syndrome (ARDS) is a common diagnosis in ICUs and has a mortality rate approaching 40%. This disease is characterized by a build-up of fluid in the alveolar sacs. Most patients exhibit heterogeneous injury, with relatively normal-appearing areas abutting densely consolidated regions. This heterogeneity makes treatment difficult. Ultrasound-destruction of microbubbles (USMB) has been demonstrated to increase drug uptake by tissues but has never been attempted in the lung. We hypothesized that USMB would only increase drug uptake in edematous lung regions, since air scatters ultrasound waves. USMB increased the deposition and efficacy of low dose gentamicin in the lungs of an E. coli-induced ARDS mouse model. Further, we validated the use of USMB drug delivery to the injured lung in a porcine pneumonia model, suggesting feasibility in humans. USMB may therefore allow for targeted delivery of therapies - antibiotics, antivirals, genes - to the injured lung in ARDS.
590 $a School code: 0779.
650 4 $a Medicine. $3 641104
650 4 $a Virology. $3 642304
650 4 $a Immunology. $3 611031
653 $a Aminoglycoside
653 $a ARDS
653 $a Drug delivery
653 $a Lung
653 $a Microbubble
653 $a Ultrasound
690 $a 0564
690 $a 0720
690 $a 0982
710 2 $a University of Toronto (Canada). $b Medical Science. $3 3182952
773 0 $t Masters Abstracts International $g 81-06.
790 $a 0779
791 $a M.Sc.
792 $a 2019
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=13902741