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Polyampholyte Hydrogels for Tissue E...

Mariner, Emily M.

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Polyampholyte Hydrogels for Tissue Engineering and Drug Delivery Applications.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Polyampholyte Hydrogels for Tissue Engineering and Drug Delivery Applications./
Author:	Mariner, Emily M.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2019,
Description:	51 p.
Notes:	Source: Masters Abstracts International, Volume: 81-03.
Contained By:	Masters Abstracts International81-03.
Subject:	Polymer chemistry. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=13815030
ISBN:	9781085604734

Polyampholyte Hydrogels for Tissue Engineering and Drug Delivery Applications.
Mariner, Emily M.

Polyampholyte Hydrogels for Tissue Engineering and Drug Delivery Applications. - Ann Arbor : ProQuest Dissertations & Theses, 2019 - 51 p.

Source: Masters Abstracts International, Volume: 81-03.

Thesis (M.Engr.)--University of Idaho, 2019.

This item must not be sold to any third party vendors.

Polyampholyte polymers are being investigated for biomedical applications such as drug delivery and tissue engineering. These polymers are composed of equimolar positively and negatively charged monomers and they possess nonfouling properties that reduce the risk of a foreign body response. Nonfouling combined with tunable mechanical and drug release properties make them very suitable for many applications in the biomedical field. In this work, the mechanical and degradation properties are characterized as a function of cross-linker species. Specifically, we evaluated the influence that the number of ethylene glycol repeat units has on the overall material performance by synthesizing and evaluating hydrogels containing di-, tri-, and tetra-ethylene glycol dimethacrylate cross-linker species. The degradation studies were conducted for over 100 days in Sorenson's buffer with pH values of 4.5, 7.4, and 9.0 by tracking the swelling behavior and weight change over time. The mechanical properties were evaluated using compression and tensile testing to failure. Additionally, a piezoelectric droplet on demand generator was designed and constructed to produce polyampholyte microspheres for drug delivery. The microspheres were composed of a 1:1 molar ratio of [2-(acryloyloxy)ethyl] trimethylammonium chloride (TMA, positively charged) and 2-carboxyethyl acrylate (CAA, negatively charged) monomers cross-linked with TEGDMA. Polymerization was initiated using LAP photoinitiator upon droplet ejection. This study evaluated the viability of using these microspheres for releasing vitamin D3 and metanil yellow into biological media. The size and nonfouling properties were also investigated. In these studies, we found that the cross-linker chain length does influence the mechanical properties and degradation behavior. Droplet generation of nonfouling polyampholyte microspheres was successful; however, there was no success with long-term drug release of vitamin D3 or metanil yellow. Polyampholytes still show promise for use in biomedical applications, though the droplet generator would need some modifications to use these microspheres for drug delivery.

ISBN: 9781085604734Subjects--Topical Terms:

3173488
Polymer chemistry.
Subjects--Index Terms:

Polyampholytes

Polyampholyte Hydrogels for Tissue Engineering and Drug Delivery Applications.
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245 1 0 $a Polyampholyte Hydrogels for Tissue Engineering and Drug Delivery Applications.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2019
300 $a 51 p.
500 $a Source: Masters Abstracts International, Volume: 81-03.
500 $a Advisor: Bernards, Matthew T.
502 $a Thesis (M.Engr.)--University of Idaho, 2019.
506 $a This item must not be sold to any third party vendors.
520 $a Polyampholyte polymers are being investigated for biomedical applications such as drug delivery and tissue engineering. These polymers are composed of equimolar positively and negatively charged monomers and they possess nonfouling properties that reduce the risk of a foreign body response. Nonfouling combined with tunable mechanical and drug release properties make them very suitable for many applications in the biomedical field. In this work, the mechanical and degradation properties are characterized as a function of cross-linker species. Specifically, we evaluated the influence that the number of ethylene glycol repeat units has on the overall material performance by synthesizing and evaluating hydrogels containing di-, tri-, and tetra-ethylene glycol dimethacrylate cross-linker species. The degradation studies were conducted for over 100 days in Sorenson's buffer with pH values of 4.5, 7.4, and 9.0 by tracking the swelling behavior and weight change over time. The mechanical properties were evaluated using compression and tensile testing to failure. Additionally, a piezoelectric droplet on demand generator was designed and constructed to produce polyampholyte microspheres for drug delivery. The microspheres were composed of a 1:1 molar ratio of [2-(acryloyloxy)ethyl] trimethylammonium chloride (TMA, positively charged) and 2-carboxyethyl acrylate (CAA, negatively charged) monomers cross-linked with TEGDMA. Polymerization was initiated using LAP photoinitiator upon droplet ejection. This study evaluated the viability of using these microspheres for releasing vitamin D3 and metanil yellow into biological media. The size and nonfouling properties were also investigated. In these studies, we found that the cross-linker chain length does influence the mechanical properties and degradation behavior. Droplet generation of nonfouling polyampholyte microspheres was successful; however, there was no success with long-term drug release of vitamin D3 or metanil yellow. Polyampholytes still show promise for use in biomedical applications, though the droplet generator would need some modifications to use these microspheres for drug delivery.
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650 4 $a Pharmaceutical sciences. $3 3173021
650 4 $a Chemical engineering. $3 560457
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653 $a Negatively charged monomers
653 $a Cross-linker chain length
653 $a Degradation behavior
690 $a 0495
690 $a 0566
690 $a 0541
690 $a 0542
690 $a 0564
690 $a 0572
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773 0 $t Masters Abstracts International $g 81-03.
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792 $a 2019
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=13815030