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Single-Nanoparticle Microscopy of DN...

Matthews, Brandon Marcellus.

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Single-Nanoparticle Microscopy of DNA-Incorporated Hydrogel Nanoparticles.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Single-Nanoparticle Microscopy of DNA-Incorporated Hydrogel Nanoparticles./
作者:	Matthews, Brandon Marcellus.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2019,
面頁冊數:	89 p.
附註:	Source: Dissertations Abstracts International, Volume: 81-03, Section: B.
Contained By:	Dissertations Abstracts International81-03B.
標題:	Physical chemistry. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=13895506
ISBN:	9781085608022

Single-Nanoparticle Microscopy of DNA-Incorporated Hydrogel Nanoparticles.
Matthews, Brandon Marcellus.

Single-Nanoparticle Microscopy of DNA-Incorporated Hydrogel Nanoparticles. - Ann Arbor : ProQuest Dissertations & Theses, 2019 - 89 p.

Source: Dissertations Abstracts International, Volume: 81-03, Section: B.

Thesis (Ph.D.)--University of California, Irvine, 2019.

This item must not be sold to any third party vendors.

This dissertation is the cumulative work towards the development of bioactive hydrogel nanoparticles by way of DNA incorporation. First, a collection of orthogonal DNA sequences is fabricated and binding coefficients quantified via surface plasmon resonance imaging (SPRI). Then, using a sample sequence from the collection, the DNA is polymerized into the backbone of hydrogel nanoparticles (HNPs) to be characterized by single-nanoparticle SPRI microscopy as surface adsorption measurements to gold thin-films. The SPRI responses, Δ%RNP, from several hundred nanoparticle adsorption events are used to generate frequency distribution histograms that characterize the nanoparticle size, composition, and bioactivity through complementary DNA hybridization and enzymatic-induced hydrolysis. These analyses reveal a dependence on the base sequence to aid in the incorporation of DNA into the HNPs. Lastly, DNA incorporation is further elaborated upon by the formation of nanocomposite HNPs, wherein the magnetic nanoparticle ferrite is present during DNA-HNP formation, alluding to a preferential covalent incorporation of DNA over that of ferrite nanoparticles as characterized by SPRI microscopy.

ISBN: 9781085608022Subjects--Topical Terms:

1981412
Physical chemistry.
Subjects--Index Terms:

Single-nanoparticle microscopy

Single-Nanoparticle Microscopy of DNA-Incorporated Hydrogel Nanoparticles.
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