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Biology at the Microscale: New Techn...

Alvarez-Garcia, Yasmin Rosaura.

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Biology at the Microscale: New Techniques for Cellular Experimentation.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Biology at the Microscale: New Techniques for Cellular Experimentation./
作者:	Alvarez-Garcia, Yasmin Rosaura.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2020,
面頁冊數:	195 p.
附註:	Source: Dissertations Abstracts International, Volume: 81-11, Section: B.
Contained By:	Dissertations Abstracts International81-11B.
標題:	Biomedical engineering. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=27962854
ISBN:	9798645443665

Biology at the Microscale: New Techniques for Cellular Experimentation.
Alvarez-Garcia, Yasmin Rosaura.

Biology at the Microscale: New Techniques for Cellular Experimentation. - Ann Arbor : ProQuest Dissertations & Theses, 2020 - 195 p.

Source: Dissertations Abstracts International, Volume: 81-11, Section: B.

Thesis (Ph.D.)--The University of Wisconsin - Madison, 2020.

This item must not be sold to any third party vendors.

Microfluidic approaches offer the ability to accurately emulate diverse microenvironments, while often outpacing traditional macro-level approaches in versatility, scalability and efficiency of production. Nevertheless, the uptake of such methods in biological research has been hampered by the absence of microfluidic systems that are specifically adapted to the needs of given investigations. This thesis attempts to show how microfluidic engineering can be more closely harnessed to the explicit needs of such objectives. Presented here is an array of systems that function on the microscale, and have been designed, fabricated, and tested to meet the needs of discrete biological questions. A microdevice is proposed that serves as a multi-culture platform for assessing multi-cell-type interactions, and a widely-applicable adhesive tool for the fabrication of such devices is tested for broader use. A novel microfluidic system for experimenting on fungal spore adhesion is discussed, and used to assay potential biocontrol agents of vital importance to agricultural production. Finally, the development of a cell immobilization technology is detailed, with an emphasis on how functioning at the microscale lends distinct advantages to the storage and imaging of rare samples. Taken overall, these technologies are intended to show that sensitivity on the engineering level can help bridge the gap between microscale tools and the biological investigations in which they offer so much promise.

ISBN: 9798645443665Subjects--Topical Terms:

535387
Biomedical engineering.
Subjects--Index Terms:

Cell immobilization

Biology at the Microscale: New Techniques for Cellular Experimentation.
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