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Determining How Endocrine Pineal Mel...

Contreras, Ethan.

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Determining How Endocrine Pineal Melatonin Affects Behavior in Nocturnal Rodents.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Determining How Endocrine Pineal Melatonin Affects Behavior in Nocturnal Rodents./
Author:	Contreras, Ethan.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2019,
Description:	106 p.
Notes:	Source: Masters Abstracts International, Volume: 81-03.
Contained By:	Masters Abstracts International81-03.
Subject:	Biology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=13901074
ISBN:	9781085678964

Determining How Endocrine Pineal Melatonin Affects Behavior in Nocturnal Rodents.
Contreras, Ethan.

Determining How Endocrine Pineal Melatonin Affects Behavior in Nocturnal Rodents. - Ann Arbor : ProQuest Dissertations & Theses, 2019 - 106 p.

Source: Masters Abstracts International, Volume: 81-03.

Thesis (M.S.)--New Mexico Institute of Mining and Technology, 2019.

This item must not be sold to any third party vendors.

Background. Detection of light in the eye regulates multiple axes of physiology and behavior including circadian rhythms, sleep propensity and the widely acting pineal hormone, melatonin. These distinct axes also interact. For example, sleep timing is determined by the circadian clock, and melatonin promotes sleep in diurnal animals, while seemingly promoting activity in nocturnal animals. These multiple interacting effects of light have made it difficult to determine the actions of a specific input pathway.Purpose. The primary goal of this project was to begin to determine how endocrine pineal melatonin contributes to the effects of light on behavior in the nocturnal house mouse, Mus Musculus.Methods. Endocrine pineal melatonin-dependent effects were identified by the comparison of surgical pinealectomy, and sham control in the C3Sn strain of mice, one of few with melatonin functionality, for:1. affect and motivation behaviors2. circadian rhythms3. sleepCircadian experiments were conducted using wheel running counts as a measurement, while affect behaviors and sleep were measured using motion tracking software.Results. An initial assessment of circadian activity showed no effect of pineal melatonin on circadian entrainment to a daily cycle of light and dark, period in complete darkness, or amplitude of phase shift to a light pulse. There was a significant decrease in both wheel running activity as defined by P values lower than 0.0025 after bonferroni correction (P=0.002 for combined gender's light phase activity) and number of sleep bouts (P=0.014 with an 80s filter) during the light phase of the day. There was no difference in other aspects of circadian rhythms and sleep, or in tested affect behaviors.Conclusions. We identified an unexpected decrease in wheel running behavior and number of sleep bouts during the day of mice lacking pineal melatonin. However, we also did not see any other changes in circadian behavior, which did not agree with our hypothesis based on studies using exogenous melatonin.

ISBN: 9781085678964Subjects--Topical Terms:

522710
Biology.
Subjects--Index Terms:

Affect behaviors

Determining How Endocrine Pineal Melatonin Affects Behavior in Nocturnal Rodents.
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500 $a Source: Masters Abstracts International, Volume: 81-03.
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506 $a This item must not be sold to any third party vendors.
506 $a This item must not be added to any third party search indexes.
520 $a Background. Detection of light in the eye regulates multiple axes of physiology and behavior including circadian rhythms, sleep propensity and the widely acting pineal hormone, melatonin. These distinct axes also interact. For example, sleep timing is determined by the circadian clock, and melatonin promotes sleep in diurnal animals, while seemingly promoting activity in nocturnal animals. These multiple interacting effects of light have made it difficult to determine the actions of a specific input pathway.Purpose. The primary goal of this project was to begin to determine how endocrine pineal melatonin contributes to the effects of light on behavior in the nocturnal house mouse, Mus Musculus.Methods. Endocrine pineal melatonin-dependent effects were identified by the comparison of surgical pinealectomy, and sham control in the C3Sn strain of mice, one of few with melatonin functionality, for:1. affect and motivation behaviors2. circadian rhythms3. sleepCircadian experiments were conducted using wheel running counts as a measurement, while affect behaviors and sleep were measured using motion tracking software.Results. An initial assessment of circadian activity showed no effect of pineal melatonin on circadian entrainment to a daily cycle of light and dark, period in complete darkness, or amplitude of phase shift to a light pulse. There was a significant decrease in both wheel running activity as defined by P values lower than 0.0025 after bonferroni correction (P=0.002 for combined gender's light phase activity) and number of sleep bouts (P=0.014 with an 80s filter) during the light phase of the day. There was no difference in other aspects of circadian rhythms and sleep, or in tested affect behaviors.Conclusions. We identified an unexpected decrease in wheel running behavior and number of sleep bouts during the day of mice lacking pineal melatonin. However, we also did not see any other changes in circadian behavior, which did not agree with our hypothesis based on studies using exogenous melatonin.
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