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Ultrahigh-speed OCT Angiography for ...

Migacz, Justin Vincent.

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Ultrahigh-speed OCT Angiography for Examining Human Retinal Angiography and Cone Photoreceptor Function.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Ultrahigh-speed OCT Angiography for Examining Human Retinal Angiography and Cone Photoreceptor Function./
Author:	Migacz, Justin Vincent.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2019,
Description:	72 p.
Notes:	Source: Dissertations Abstracts International, Volume: 81-02, Section: B.
Contained By:	Dissertations Abstracts International81-02B.
Subject:	Biomedical engineering. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=13427374
ISBN:	9781085586030

Ultrahigh-speed OCT Angiography for Examining Human Retinal Angiography and Cone Photoreceptor Function.
Migacz, Justin Vincent.

Ultrahigh-speed OCT Angiography for Examining Human Retinal Angiography and Cone Photoreceptor Function. - Ann Arbor : ProQuest Dissertations & Theses, 2019 - 72 p.

Source: Dissertations Abstracts International, Volume: 81-02, Section: B.

Thesis (Ph.D.)--University of California, Davis, 2019.

This item must not be sold to any third party vendors.

Optical coherence tomography (OCT) is a biomedical imaging modality that has been adopted successfully in several clinical fields but especially within ophthalmology. Functional imaging with OCT for blood-velocity measurements has been demonstrated by research groups since the early years of OCT development, but it is only in recent years that commercial OCT developers haven been deploying blood-vessel imaging systems. This approach, termed OCT Angiography (OCTA) has enabled active research in bioengineering and ophthalmic applications. Though OCTA measurements do not quantify the blood velocity, but rather visualize vasculature perfusion, it may still provide insight into significant blinding diseases such as age-related macular degeneration. In this work, we have utilized an ultrahigh-speed tunable laser, a Fourier-domain mode-locked (FDML) swept-source, to create high-contrast mapping of the human eye's retinal vasculature despite the reduction in signal sensitivity for fast acquisitions. We have focused our efforts on visualizing the choriocapillaris network, a subretinal structure which may have significant involvement in age-related disease. The unprecedented speed of the FDML source (1.64M A-scans/sec) allows us to operate at frame rates of 10-20 times that of most OCT systems and creates the highest-contrast choriocapillaris images to date. Along with demonstrating this custom-built system on normal subjects, we have also examined subjects with age-related macular degeneration at various stages of the disease. Lastly, we have incorporated the FDML source in an adaptive optics OCT system, and demonstrated that we can resolve quick, subpixel length changes of cone photoreceptors of the human eye in response to light stimulation. With these two systems, we have detected morphological features and dynamics that may prove valuable to clinicians studying human eye ailments.

ISBN: 9781085586030Subjects--Topical Terms:

535387
Biomedical engineering.

Ultrahigh-speed OCT Angiography for Examining Human Retinal Angiography and Cone Photoreceptor Function.
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245 1 0 $a Ultrahigh-speed OCT Angiography for Examining Human Retinal Angiography and Cone Photoreceptor Function.
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300 $a 72 p.
500 $a Source: Dissertations Abstracts International, Volume: 81-02, Section: B.
500 $a Advisor: Werner, John S.
502 $a Thesis (Ph.D.)--University of California, Davis, 2019.
506 $a This item must not be sold to any third party vendors.
520 $a Optical coherence tomography (OCT) is a biomedical imaging modality that has been adopted successfully in several clinical fields but especially within ophthalmology. Functional imaging with OCT for blood-velocity measurements has been demonstrated by research groups since the early years of OCT development, but it is only in recent years that commercial OCT developers haven been deploying blood-vessel imaging systems. This approach, termed OCT Angiography (OCTA) has enabled active research in bioengineering and ophthalmic applications. Though OCTA measurements do not quantify the blood velocity, but rather visualize vasculature perfusion, it may still provide insight into significant blinding diseases such as age-related macular degeneration. In this work, we have utilized an ultrahigh-speed tunable laser, a Fourier-domain mode-locked (FDML) swept-source, to create high-contrast mapping of the human eye's retinal vasculature despite the reduction in signal sensitivity for fast acquisitions. We have focused our efforts on visualizing the choriocapillaris network, a subretinal structure which may have significant involvement in age-related disease. The unprecedented speed of the FDML source (1.64M A-scans/sec) allows us to operate at frame rates of 10-20 times that of most OCT systems and creates the highest-contrast choriocapillaris images to date. Along with demonstrating this custom-built system on normal subjects, we have also examined subjects with age-related macular degeneration at various stages of the disease. Lastly, we have incorporated the FDML source in an adaptive optics OCT system, and demonstrated that we can resolve quick, subpixel length changes of cone photoreceptors of the human eye in response to light stimulation. With these two systems, we have detected morphological features and dynamics that may prove valuable to clinicians studying human eye ailments.
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