Introductory review on sirtuins in b...
Guarente, Leonard,

FindBook      Google Book      Amazon      博客來     
  • Introductory review on sirtuins in biology, aging, and disease
  • 紀錄類型: 書目-電子資源 : Monograph/item
    正題名/作者: Introductory review on sirtuins in biology, aging, and disease/ edited by Leonard Guarente, Raul Mostoslavsky, Alaksey Kazantsev.
    其他作者: Guarente, Leonard,
    出版者: London :Academic Press, : 2018.,
    面頁冊數: 1 online resource :ill.
    內容註: Intro; Title page; Table of Contents; Copyright; Dedication; List of Contributors; Biographies; Introduction; Reference; Chapter 1. Sirtuins, NAD+, Aging, and Disease: A Retrospective and Prospective Overview; Abstract; Acknowledgments; Further Reading; Chapter 2. Regulation of Sirtuins by Systemic NAD+ Biosynthesis; Abstract; Acknowledgments; 2.1 Introduction; 2.2 NAD+ Biosynthesis, Consumption, and Degradation; 2.3 The Role of NAD+ Biosynthesis and Sirtuins in Tissue Homeostasis and Disease Conditions.
    內容註: 2.4 The Concept of the NAD World: The NAMPT/NAD+/SIRT1-Mediated Systemic Regulatory Network for Aging and Longevity Control in Mammals2.5 Concluding Remarks; References; Chapter 3. NAD+ Modulation: Biology and Therapy; Abstract; 3.1A Bit of History; 3.2 How NAD+ Is Produced; 3.3 NAM, NA, NR, or Tryptophan?; 3.4 Compartmentalization of NAD+ Homeostasis Within the Cell; 3.5 NAD+ as a Regulator of Sirtuin Activity; 3.6 NAD+ Besides Sirtuins; 3.7 NAD+ Boosting Strategies;3.8 Therapeutic Potential of NAD+ Boosting; 3.9 Conclusion; References; Chapter 4. The Enzymatic Activities of Sirtuins.
    內容註: AbstractAcknowledgments; 4.1 Desuccinylation, Demalonylation, and Deglutarylation Catalyzed by SIRT5; 4.2 Hydrolysis of Long-Chain Fatty Acyl Groups (Defatty-Acylation) by Several Sirtuins; 4.3 The Various Deacylation Activities Reported for SIRT4; 4.4 The ADP-Ribosyltransferase Activity of Sirtuins; 4.5 Special Consideration for Sirtuins That Can Recognize Structurally Very Different Acyl Groups; 4.6 Factors That Affect Sirtuin Substrate Specificity; 4.7 Summary and Concluding Remarks; References.
    內容註: Chapter 5. Structural and Mechanistic Insights in Sirtuin Catalysis and Pharmacological ModulationAbstract; 5.1 Sirtuin Function, Structure, and Catalytic Mechanism; 5.2 Sirtuin Inhibitors; 5.3 Sirtuin Activators; 5.4 Outlook; References; Chapter 6. Pharmacological Approaches for Modulating Sirtuins; Abstract; 6.1 Introduction; 6.2 Allosteric Activators of Sirtuins; 6.3 Pharmacological Modulation of NAD+; 6.4 Beneficial Health Effects of STACs; 6.5 Beneficial Health Effects of NBMs; 6.6 Conclusions; References; Chapter 7. Reactive Acyl-CoA Species and Deacylation by the Mitochondrial Sirtuins.
    內容註: AbstractAcknowledgments; 7.1 Introduction; 7.2 Enzymatic Activity of the Mitochondrial Sirtuins; 7.3 Proteomic Characterization of Acyl-Lysine Modifications; 7.4 The Roles of Mitochondrial Sirtuins Under Basal Conditions; 7.5 Physiological Roles of Mitochondrial Sirtuins in the Heart; 7.6 Reactive Acyl-CoA Species and Carbon Stress; 7.7 RACS, Metabolism, and Heart Failure; 7.8 Conclusions; References; Chapter 8. Mitochondrial Sirtuins: Coordinating Stress Responses Through Regulation of Mitochondrial Enzyme Networks; Abstract; 8.1 Introduction; 8.2 SIRT3; 8.3 SIRT4; 8.4 SIRT5.
    標題: Sirtuins. -
    電子資源: https://www.sciencedirect.com/science/book/9780128134993
    ISBN: 9780128135006 (electronic bk.)
館藏地:  出版年:  卷號: 
館藏
  • 1 筆 • 頁數 1 •
  • 1 筆 • 頁數 1 •
多媒體
評論
Export
取書館
 
 
變更密碼
登入