東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Protein instability at interfaces du...

Li, Jinjiang.

FindBook

Google Book

Amazon

博客來

Protein instability at interfaces during drug product development = fundamental understanding, evaluation, and mitigation /

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Protein instability at interfaces during drug product development/ edited by Jinjiang Li, Mary E. Krause, Raymond Tu.
其他題名:	fundamental understanding, evaluation, and mitigation /
其他作者:	Li, Jinjiang.
出版者:	Cham :Springer International Publishing : : 2021.,
面頁冊數:	viii, 338 p. :ill., digital ;24 cm.
內容註:	1. Overview of the impact of protein interfacial instability on the development of biologic products -- 2. Protein adsorption at a gas-aqueous interface -- 3. Interfacial behaviors of proteins -- 4. Interfacial stresses during drug substance purification processes -- 5. Evaluation of interfacial stress during drug product development -- 6.Relating interfacial shear and dilatations stress-es to protein aggregation in mAbs -- 7. Analytical techniques for evaluating protein instability at interfaces -- 8. Analysis of aggregates and particles -- 9. Protein interfacial instability of mixing and lyophilization during drug product manufacturing process scale-up and tech transfer -- 10. Excipients: Characterization, purpose, and selection -- 11. Interfacial stress and proteins prepared in the solid state -- 12. Interfaces in protein drug delivery: device concern -- 13. Future perspectives.
Contained By:	Springer Nature eBook
標題:	Drug development. -
電子資源:	https://doi.org/10.1007/978-3-030-57177-1
ISBN:	9783030571771

Protein instability at interfaces during drug product development = fundamental understanding, evaluation, and mitigation /
Protein instability at interfaces during drug product developmentfundamental understanding, evaluation, and mitigation /[electronic resource] :edited by Jinjiang Li, Mary E. Krause, Raymond Tu. - Cham :Springer International Publishing :2021. - viii, 338 p. :ill., digital ;24 cm. - AAPS advances in the pharmaceutical sciences series,432210-7371 ;. - AAPS advances in the pharmaceutical sciences series ;43..

1. Overview of the impact of protein interfacial instability on the development of biologic products -- 2. Protein adsorption at a gas-aqueous interface -- 3. Interfacial behaviors of proteins -- 4. Interfacial stresses during drug substance purification processes -- 5. Evaluation of interfacial stress during drug product development -- 6.Relating interfacial shear and dilatations stress-es to protein aggregation in mAbs -- 7. Analytical techniques for evaluating protein instability at interfaces -- 8. Analysis of aggregates and particles -- 9. Protein interfacial instability of mixing and lyophilization during drug product manufacturing process scale-up and tech transfer -- 10. Excipients: Characterization, purpose, and selection -- 11. Interfacial stress and proteins prepared in the solid state -- 12. Interfaces in protein drug delivery: device concern -- 13. Future perspectives.

Proteins are exposed to various interfacial stresses during drug product development. They are subjected to air-liquid, liquid-solid, and, sometimes, liquid-liquid interfaces throughout the development cycle-from manufacturing of drug substances to storage and drug delivery. Unlike small molecule drugs, proteins are typically unstable at interfaces where, on adsorption, they often denature and form aggregates, resulting in loss of efficacy and potential immunogenicity. This book covers both the fundamental aspects of proteins at interfaces and the quantification of interfacial behaviors of proteins. Importantly, this book introduces the industrial aspects of protein instabilities at interfaces, including the processes that introduce new interfaces, evaluation of interfacial instabilities, and mitigation strategies. The audience that this book targets encompasses scientists in the pharmaceutical and biotech industry, as well as faculty and students from academia in the surface science, pharmaceutical, and medicinal chemistry areas.

ISBN: 9783030571771

Standard No.: 10.1007/978-3-030-57177-1doiSubjects--Topical Terms:

716904
Drug development.

LC Class. No.: RM301.25

Dewey Class. No.: 615.19

Protein instability at interfaces during drug product development = fundamental understanding, evaluation, and mitigation /
LDR:03103nmm a2200337 a 4500 001 2237868
003 DE-He213
005 20210419141451.0
006 m d
007 cr nn 008maaau
008 211111s2021 sz s 0 eng d
020 $a 9783030571771 $q (electronic bk.)
020 $a 9783030571764 $q (paper)
024 7 $a 10.1007/978-3-030-57177-1 $2 doi
035 $a 978-3-030-57177-1
040 $a GP $c GP
041 0 $a eng
050 4 $a RM301.25
072 7 $a MMG $2 bicssc
072 7 $a MED071000 $2 bisacsh
072 7 $a MKG $2 thema
082 0 4 $a 615.19 $2 23
090 $a RM301.25 $b .P967 2021
245 0 0 $a Protein instability at interfaces during drug product development $h [electronic resource] : $b fundamental understanding, evaluation, and mitigation / $c edited by Jinjiang Li, Mary E. Krause, Raymond Tu.
260 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2021.
300 $a viii, 338 p. : $b ill., digital ; $c 24 cm.
490 1 $a AAPS advances in the pharmaceutical sciences series, $x 2210-7371 ; $v 43
505 0 $a 1. Overview of the impact of protein interfacial instability on the development of biologic products -- 2. Protein adsorption at a gas-aqueous interface -- 3. Interfacial behaviors of proteins -- 4. Interfacial stresses during drug substance purification processes -- 5. Evaluation of interfacial stress during drug product development -- 6.Relating interfacial shear and dilatations stress-es to protein aggregation in mAbs -- 7. Analytical techniques for evaluating protein instability at interfaces -- 8. Analysis of aggregates and particles -- 9. Protein interfacial instability of mixing and lyophilization during drug product manufacturing process scale-up and tech transfer -- 10. Excipients: Characterization, purpose, and selection -- 11. Interfacial stress and proteins prepared in the solid state -- 12. Interfaces in protein drug delivery: device concern -- 13. Future perspectives.
520 $a Proteins are exposed to various interfacial stresses during drug product development. They are subjected to air-liquid, liquid-solid, and, sometimes, liquid-liquid interfaces throughout the development cycle-from manufacturing of drug substances to storage and drug delivery. Unlike small molecule drugs, proteins are typically unstable at interfaces where, on adsorption, they often denature and form aggregates, resulting in loss of efficacy and potential immunogenicity. This book covers both the fundamental aspects of proteins at interfaces and the quantification of interfacial behaviors of proteins. Importantly, this book introduces the industrial aspects of protein instabilities at interfaces, including the processes that introduce new interfaces, evaluation of interfacial instabilities, and mitigation strategies. The audience that this book targets encompasses scientists in the pharmaceutical and biotech industry, as well as faculty and students from academia in the surface science, pharmaceutical, and medicinal chemistry areas.
650 0 $a Drug development. $3 716904
650 0 $a Proteins $x Therapeutic use. $3 1005397
650 0 $a Biological interfaces. $3 720513
650 1 4 $a Pharmacology/Toxicology. $3 890953
650 2 4 $a Pharmacy. $3 636101
650 2 4 $a Pharmaceutical Sciences/Technology. $3 1001579
650 2 4 $a Theoretical and Computational Chemistry. $3 890863
650 2 4 $a Biotechnology. $3 571461
700 1 $a Li, Jinjiang. $3 3490459
700 1 $a Krause, Mary E. $3 3490460
700 1 $a Tu, Raymond. $3 3490461
710 2 $a SpringerLink (Online service) $3 836513
773 0 $t Springer Nature eBook
830 0 $a AAPS advances in the pharmaceutical sciences series ; $v 43. $3 3490462
856 4 0 $u https://doi.org/10.1007/978-3-030-57177-1
950 $a Biomedical and Life Sciences (SpringerNature-11642)