東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Histone mutations and cancer

Fang, Dong.

Linked to FindBook

Google Book

Amazon

博客來

Histone mutations and cancer

Record Type:	Electronic resources : Monograph/item
Title/Author:	Histone mutations and cancer/ edited by Dong Fang, Junhong Han.
other author:	Fang, Dong.
Published:	Singapore :Springer Singapore : : 2021.,
Description:	vii, 96 p. :ill. (some col.), digital ;24 cm.
[NT 15003449]:	Chapter 1: Overview of histone modification -- Chapter 2: The histone H3 family and its deposition pathways -- Chapter 3: Histone H3K27M Mutation in Brain Tumors -- Chapter 4: Histone Mutations and Bone Cancers -- Chapter 5: Histone H3G34 mutation in brain and bone tumors -- Chapter 6: Epigenetic-targeted treatments for H3K27M-mutant midline gliomas -- Chapter 7: Histone lysine to methionine mutation as anti-cancer drug target.
Contained By:	Springer Nature eBook
Subject:	Histones. -
Online resource:	https://doi.org/10.1007/978-981-15-8104-5
ISBN:	9789811581045

Histone mutations and cancer
Histone mutations and cancer[electronic resource] /edited by Dong Fang, Junhong Han. - Singapore :Springer Singapore :2021. - vii, 96 p. :ill. (some col.), digital ;24 cm. - Advances in experimental medicine and biology,v.12830065-2598 ;. - Advances in experimental medicine and biology ;v.1283..

Chapter 1: Overview of histone modification -- Chapter 2: The histone H3 family and its deposition pathways -- Chapter 3: Histone H3K27M Mutation in Brain Tumors -- Chapter 4: Histone Mutations and Bone Cancers -- Chapter 5: Histone H3G34 mutation in brain and bone tumors -- Chapter 6: Epigenetic-targeted treatments for H3K27M-mutant midline gliomas -- Chapter 7: Histone lysine to methionine mutation as anti-cancer drug target.

This book focuses on histone mutations, especially those mutations closely related to cancer. Genetic mutations and epigenetic alterations contribute to the development of a variety of cancers: recent genetic studies have identified e.g. H3K27M and H3G34R/V mutation in over 75% of DIPG cases, H3.3K36M mutation in more than 90% of chondroblastoma cases, and H3G34W/L mutation in over 90% of giant cell tumors of bone. Given the high incidence and tumorigenesis effects of histone H3 mutations, they are also referred to as oncohistones. This book highlights the advances made in the area over the past 10 years, and offers a state-of-the-art summary of epigenetic alternation, gene expression, protein structure, drug discovery, immunotherapy, and mouse modeling of histone H3 mutations in various tumors. Chiefly intended to provide researchers and graduate students with an overall picture of these mutations, it will also be of interest to researchers in basic oncology, clinical oncology, and epigenetics, as well as academics and clinical oncology practitioners.

ISBN: 9789811581045

Standard No.: 10.1007/978-981-15-8104-5doiSubjects--Topical Terms:

1601926
Histones.

LC Class. No.: QP552.H5 / H57 2021

Dewey Class. No.: 572.66

Histone mutations and cancer
LDR:02580nmm a2200337 a 4500 001 2236202
003 DE-He213
005 20201106040331.0
006 m d
007 cr nn 008maaau
008 211111s2021 si s 0 eng d
020 $a 9789811581045 $q (electronic bk.)
020 $a 9789811581038 $q (paper)
024 7 $a 10.1007/978-981-15-8104-5 $2 doi
035 $a 978-981-15-8104-5
040 $a GP $c GP $e rda
041 0 $a eng
050 4 $a QP552.H5 $b H57 2021
072 7 $a MJCL $2 bicssc
072 7 $a MED062000 $2 bisacsh
072 7 $a MJCL $2 thema
082 0 4 $a 572.66 $2 23
090 $a QP552.H5 $b H673 2021
245 0 0 $a Histone mutations and cancer $h [electronic resource] / $c edited by Dong Fang, Junhong Han.
260 $a Singapore : $b Springer Singapore : $b Imprint: Springer, $c 2021.
300 $a vii, 96 p. : $b ill. (some col.), digital ; $c 24 cm.
490 1 $a Advances in experimental medicine and biology, $x 0065-2598 ; $v v.1283
505 0 $a Chapter 1: Overview of histone modification -- Chapter 2: The histone H3 family and its deposition pathways -- Chapter 3: Histone H3K27M Mutation in Brain Tumors -- Chapter 4: Histone Mutations and Bone Cancers -- Chapter 5: Histone H3G34 mutation in brain and bone tumors -- Chapter 6: Epigenetic-targeted treatments for H3K27M-mutant midline gliomas -- Chapter 7: Histone lysine to methionine mutation as anti-cancer drug target.
520 $a This book focuses on histone mutations, especially those mutations closely related to cancer. Genetic mutations and epigenetic alterations contribute to the development of a variety of cancers: recent genetic studies have identified e.g. H3K27M and H3G34R/V mutation in over 75% of DIPG cases, H3.3K36M mutation in more than 90% of chondroblastoma cases, and H3G34W/L mutation in over 90% of giant cell tumors of bone. Given the high incidence and tumorigenesis effects of histone H3 mutations, they are also referred to as oncohistones. This book highlights the advances made in the area over the past 10 years, and offers a state-of-the-art summary of epigenetic alternation, gene expression, protein structure, drug discovery, immunotherapy, and mouse modeling of histone H3 mutations in various tumors. Chiefly intended to provide researchers and graduate students with an overall picture of these mutations, it will also be of interest to researchers in basic oncology, clinical oncology, and epigenetics, as well as academics and clinical oncology practitioners.
650 0 $a Histones. $3 1601926
650 0 $a Mutation (Biology) $3 816753
650 0 $a Cancer $x Research. $3 696466
650 0 $a Gene expression. $3 643979
650 0 $a Proteins. $3 558769
650 1 4 $a Cancer Research. $3 891172
650 2 4 $a Gene Expression. $3 600530
650 2 4 $a Protein Science. $3 1067276
700 1 $a Fang, Dong. $3 3487370
700 1 $a Han, Junhong. $3 3487371
710 2 $a SpringerLink (Online service) $3 836513
773 0 $t Springer Nature eBook
830 0 $a Advances in experimental medicine and biology ; $v v.1283. $3 3487372
856 4 0 $u https://doi.org/10.1007/978-981-15-8104-5
950 $a Biomedical and Life Sciences (SpringerNature-11642)