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Electrochemical Radiofluorination: C...

Allison, Nathanael.

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Electrochemical Radiofluorination: Carrier and No-Carrier-Added 18F Labelling of Thioethers and Aromatics for use as Positron Emission Tomography Probes.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Electrochemical Radiofluorination: Carrier and No-Carrier-Added 18F Labelling of Thioethers and Aromatics for use as Positron Emission Tomography Probes./
作者:	Allison, Nathanael.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2018,
面頁冊數:	231 p.
附註:	Source: Dissertations Abstracts International, Volume: 80-06, Section: B.
Contained By:	Dissertations Abstracts International80-06B.
標題:	Chemistry. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=13423525
ISBN:	9780438745650

Electrochemical Radiofluorination: Carrier and No-Carrier-Added 18F Labelling of Thioethers and Aromatics for use as Positron Emission Tomography Probes.
Allison, Nathanael.

Electrochemical Radiofluorination: Carrier and No-Carrier-Added 18F Labelling of Thioethers and Aromatics for use as Positron Emission Tomography Probes. - Ann Arbor : ProQuest Dissertations & Theses, 2018 - 231 p.

Source: Dissertations Abstracts International, Volume: 80-06, Section: B.

Thesis (Ph.D.)--University of California, Los Angeles, 2018.

This item is not available from ProQuest Dissertations & Theses.

Thioether and aromatic molecules were electrochemically radiolabeled with [18F]Fluoride under carrier-added and no-carrier-added conditions. The addition of excess carrier fluoride (i.e. stable isotope fluoride) in traditional electrochemical fluorination leads to low fluorination yields, which cause low radiochemical yields and molar activity when using [ 18F]Fluoride. Electrochemical syntheses were extensively investigated herein and optimized to remove the need for the addition of excess carrier fluoride, increasing radiochemical yield and molar activity rendering this electrochemical methodology suitable for the potential use in Positron Emission Tomography radiotracer synthesis. The electrochemical fluorination mechanisms of ECEC, where E is an electrochemical process and C is a chemical reaction, and fluoro-Pummerer rearrangement were explored with the transition to no-carrier-added conditions. New electrochemical fluorination methods and novel reaction conditions were used to perform no-carrier-added 18F-radiolabeling of thioethers and aromatics with improved radiochemical yield and molar activity for use in the synthesis of radiotracers for Positron Emission Tomography.

ISBN: 9780438745650Subjects--Topical Terms:

516420
Chemistry.

Electrochemical Radiofluorination: Carrier and No-Carrier-Added 18F Labelling of Thioethers and Aromatics for use as Positron Emission Tomography Probes.
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502 $a Thesis (Ph.D.)--University of California, Los Angeles, 2018.
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520 $a Thioether and aromatic molecules were electrochemically radiolabeled with [18F]Fluoride under carrier-added and no-carrier-added conditions. The addition of excess carrier fluoride (i.e. stable isotope fluoride) in traditional electrochemical fluorination leads to low fluorination yields, which cause low radiochemical yields and molar activity when using [ 18F]Fluoride. Electrochemical syntheses were extensively investigated herein and optimized to remove the need for the addition of excess carrier fluoride, increasing radiochemical yield and molar activity rendering this electrochemical methodology suitable for the potential use in Positron Emission Tomography radiotracer synthesis. The electrochemical fluorination mechanisms of ECEC, where E is an electrochemical process and C is a chemical reaction, and fluoro-Pummerer rearrangement were explored with the transition to no-carrier-added conditions. New electrochemical fluorination methods and novel reaction conditions were used to perform no-carrier-added 18F-radiolabeling of thioethers and aromatics with improved radiochemical yield and molar activity for use in the synthesis of radiotracers for Positron Emission Tomography.
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