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Dissolved Hyperpolarized 129Xe MRI f...

Zanette, Brandon Robert.

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Dissolved Hyperpolarized 129Xe MRI for Functional Imaging of Radiation-Induced Lung Injury.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Dissolved Hyperpolarized 129Xe MRI for Functional Imaging of Radiation-Induced Lung Injury./
Author:	Zanette, Brandon Robert.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2018,
Description:	132 p.
Notes:	Source: Dissertations Abstracts International, Volume: 80-06, Section: B.
Contained By:	Dissertations Abstracts International80-06B.
Subject:	Medical imaging. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10937500
ISBN:	9780438684508

Dissolved Hyperpolarized 129Xe MRI for Functional Imaging of Radiation-Induced Lung Injury.
Zanette, Brandon Robert.

Dissolved Hyperpolarized 129Xe MRI for Functional Imaging of Radiation-Induced Lung Injury. - Ann Arbor : ProQuest Dissertations & Theses, 2018 - 132 p.

Source: Dissertations Abstracts International, Volume: 80-06, Section: B.

Thesis (Ph.D.)--University of Toronto (Canada), 2018.

This item must not be sold to any third party vendors.

Hyperpolarized (HP) 129Xe Magnetic Resonance Imaging (MRI) of the lungs allows for the visualization of the spatial distribution of gas in the pulmonary airspaces upon inhalation by taking advantage of the 100,000 fold increase in signal. This technique yields high quality anatomical and functional images of the lungs that is otherwise difficult with conventional MRI. Direct imaging of lung ventilation is useful for the detection and quantification of obstructive lung diseases such as cystic fibrosis, chronic obstructive pulmonary disorder, and asthma. An added advantage of 129X is its solubility in bodily tissues such as the lung parenchyma and red blood cells, allowing for the detection of signals from beyond the airspaces. This property of 129X may be exploited to probe gas exchange upon inhalation, making HP 129X MRI a powerful tool for the investigation of terminal airway dysfunction in a variety of pulmonary diseases. However, the inherent challenges associated with dissolved 129X MRI has caused development of these techniques to lag ventilation (gas-phase) HP 129X MRI. The work in this thesis is focused on the technical development of dissolved 129X imaging techniques for use in both human and rodent experiments. A particular focus is given to radiation-induced lung injury (RILI), a serious and debilitating consequence of radiotherapy that affects a subset of patients. A new rat model of RILI that better represents regional injury is developed and tested. Temporally-resolved dissolved 129X imaging techniques for gas exchange mapping are developed and applied to the study of RILI in this model. Changes in lung physiology associated with radiation injury are quantified by parametrically mapping gas exchange. Finally, the techniques developed preclinically are modified and improved for clinical use. Parametric gas exchange mapping is demonstrated in humans. Accelerated dissolved 129X MRI with parallel imaging is also demonstrated. The results of this work will aid in the translations of dissolved 129X MRI into a clinically useful technique for a variety of lung diseases affecting gas exchange in the lungs, such as RILI.

ISBN: 9780438684508Subjects--Topical Terms:

3172799
Medical imaging.

Dissolved Hyperpolarized 129Xe MRI for Functional Imaging of Radiation-Induced Lung Injury.
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500 $a Publisher info.: Dissertation/Thesis.
500 $a Advisor: Santyr, Giles.
502 $a Thesis (Ph.D.)--University of Toronto (Canada), 2018.
506 $a This item must not be sold to any third party vendors.
520 $a Hyperpolarized (HP) 129Xe Magnetic Resonance Imaging (MRI) of the lungs allows for the visualization of the spatial distribution of gas in the pulmonary airspaces upon inhalation by taking advantage of the 100,000 fold increase in signal. This technique yields high quality anatomical and functional images of the lungs that is otherwise difficult with conventional MRI. Direct imaging of lung ventilation is useful for the detection and quantification of obstructive lung diseases such as cystic fibrosis, chronic obstructive pulmonary disorder, and asthma. An added advantage of 129X is its solubility in bodily tissues such as the lung parenchyma and red blood cells, allowing for the detection of signals from beyond the airspaces. This property of 129X may be exploited to probe gas exchange upon inhalation, making HP 129X MRI a powerful tool for the investigation of terminal airway dysfunction in a variety of pulmonary diseases. However, the inherent challenges associated with dissolved 129X MRI has caused development of these techniques to lag ventilation (gas-phase) HP 129X MRI. The work in this thesis is focused on the technical development of dissolved 129X imaging techniques for use in both human and rodent experiments. A particular focus is given to radiation-induced lung injury (RILI), a serious and debilitating consequence of radiotherapy that affects a subset of patients. A new rat model of RILI that better represents regional injury is developed and tested. Temporally-resolved dissolved 129X imaging techniques for gas exchange mapping are developed and applied to the study of RILI in this model. Changes in lung physiology associated with radiation injury are quantified by parametrically mapping gas exchange. Finally, the techniques developed preclinically are modified and improved for clinical use. Parametric gas exchange mapping is demonstrated in humans. Accelerated dissolved 129X MRI with parallel imaging is also demonstrated. The results of this work will aid in the translations of dissolved 129X MRI into a clinically useful technique for a variety of lung diseases affecting gas exchange in the lungs, such as RILI.
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