東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Characterization of Degradation Prof...

Chen, Naihan.

FindBook

Google Book

Amazon

博客來

Characterization of Degradation Profiles of Acetalated Dextran Microparticles and Their Application for Immune Modulation.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Characterization of Degradation Profiles of Acetalated Dextran Microparticles and Their Application for Immune Modulation./
作者:	Chen, Naihan.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2018,
面頁冊數:	252 p.
附註:	Source: Dissertations Abstracts International, Volume: 80-12, Section: B.
Contained By:	Dissertations Abstracts International80-12B.
標題:	Pharmaceutical sciences. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10935214
ISBN:	9781392199411

Characterization of Degradation Profiles of Acetalated Dextran Microparticles and Their Application for Immune Modulation.
Chen, Naihan.

Characterization of Degradation Profiles of Acetalated Dextran Microparticles and Their Application for Immune Modulation. - Ann Arbor : ProQuest Dissertations & Theses, 2018 - 252 p.

Source: Dissertations Abstracts International, Volume: 80-12, Section: B.

Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2018.

This item must not be sold to any third party vendors.

Immune modulation has been widely explored as a robust tool given the essential role played by the immune system at establishing host defense. Immune responses can be up or down regulated in a specific manner to prevent and/or treat various diseases. Vaccination and autoimmune disease treatment represent two arms of immunomodulation applications, with vaccination prophylactically boosting host immunity against a specific antigen, while autoimmune treatments suppress the immune system to achieve therapeutic effect. This thesis aims to characterize and optimize vaccination and autoimmune disease treatment using a polymeric particulate delivery platform. Despite general success of vaccine and autoimmune therapy, both processes can be improved and optimized. For vaccines, poor immunogenicity of subunit vaccines often requires delivery vehicles for substantial protection. However, limited control over delivery profiles is available with current platforms. Due to significant impact of precise control over delivery kinetics on immune activation profiles, an enhanced delivery platform with flexible tunability in cargo delivery is in great need. For autoimmune treatment, although general immune suppression alleviates disease symptoms, severe adverse side effects that result from blanket inhibition call for alternative approaches. While researchers have started to explore antigen-specific therapies, options are limited and often with substantial cost or little flexibility. Work outlined in this thesis demonstrates how acetalated dextran (Ace-DEX) particles can be applied to characterize and optimize vaccination profiles and improve autoimmune treatment outcome. By offering tunable delivery profiles, generating robust protection after vaccination, and developing potent and specific immune suppression for autoimmune treatment, the Ace-DEX delivery system improves safety and efficacy of vaccines and autoimmune treatment, contributing to better immune modulation therapies.

ISBN: 9781392199411Subjects--Topical Terms:

3173021
Pharmaceutical sciences.

Characterization of Degradation Profiles of Acetalated Dextran Microparticles and Their Application for Immune Modulation.
LDR:03124nmm a2200313 4500 001 2210570
005 20191121124240.5
008 201008s2018 ||||||||||||||||| ||eng d
020 $a 9781392199411
035 $a (MiAaPQ)AAI10935214
035 $a (MiAaPQ)unc:18140
035 $a AAI10935214
040 $a MiAaPQ $c MiAaPQ
100 1 $a Chen, Naihan. $3 3437708
245 1 0 $a Characterization of Degradation Profiles of Acetalated Dextran Microparticles and Their Application for Immune Modulation.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2018
300 $a 252 p.
500 $a Source: Dissertations Abstracts International, Volume: 80-12, Section: B.
500 $a Publisher info.: Dissertation/Thesis.
500 $a Advisor: Ainslie, Kristy M.;Jay, Michael.
502 $a Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2018.
506 $a This item must not be sold to any third party vendors.
520 $a Immune modulation has been widely explored as a robust tool given the essential role played by the immune system at establishing host defense. Immune responses can be up or down regulated in a specific manner to prevent and/or treat various diseases. Vaccination and autoimmune disease treatment represent two arms of immunomodulation applications, with vaccination prophylactically boosting host immunity against a specific antigen, while autoimmune treatments suppress the immune system to achieve therapeutic effect. This thesis aims to characterize and optimize vaccination and autoimmune disease treatment using a polymeric particulate delivery platform. Despite general success of vaccine and autoimmune therapy, both processes can be improved and optimized. For vaccines, poor immunogenicity of subunit vaccines often requires delivery vehicles for substantial protection. However, limited control over delivery profiles is available with current platforms. Due to significant impact of precise control over delivery kinetics on immune activation profiles, an enhanced delivery platform with flexible tunability in cargo delivery is in great need. For autoimmune treatment, although general immune suppression alleviates disease symptoms, severe adverse side effects that result from blanket inhibition call for alternative approaches. While researchers have started to explore antigen-specific therapies, options are limited and often with substantial cost or little flexibility. Work outlined in this thesis demonstrates how acetalated dextran (Ace-DEX) particles can be applied to characterize and optimize vaccination profiles and improve autoimmune treatment outcome. By offering tunable delivery profiles, generating robust protection after vaccination, and developing potent and specific immune suppression for autoimmune treatment, the Ace-DEX delivery system improves safety and efficacy of vaccines and autoimmune treatment, contributing to better immune modulation therapies.
590 $a School code: 0153.
650 4 $a Pharmaceutical sciences. $3 3173021
690 $a 0572
710 2 $a The University of North Carolina at Chapel Hill. $b Pharmaceutical Sciences. $3 1285238
773 0 $t Dissertations Abstracts International $g 80-12B.
790 $a 0153
791 $a Ph.D.
792 $a 2018
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10935214