語系:
繁體中文
English
說明(常見問題)
回圖書館首頁
手機版館藏查詢
登入
回首頁
切換:
標籤
|
MARC模式
|
ISBD
Optoelectronic Neural Implant Sensor...
~
Choi, Christopher.
FindBook
Google Book
Amazon
博客來
Optoelectronic Neural Implant Sensors for Cerebral Blood Volume Monitoring.
紀錄類型:
書目-電子資源 : Monograph/item
正題名/作者:
Optoelectronic Neural Implant Sensors for Cerebral Blood Volume Monitoring./
作者:
Choi, Christopher.
出版者:
Ann Arbor : ProQuest Dissertations & Theses, : 2018,
面頁冊數:
96 p.
附註:
Source: Dissertations Abstracts International, Volume: 79-11, Section: B.
Contained By:
Dissertations Abstracts International79-11B.
標題:
Electrical engineering. -
電子資源:
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10793983
ISBN:
9780355906400
Optoelectronic Neural Implant Sensors for Cerebral Blood Volume Monitoring.
Choi, Christopher.
Optoelectronic Neural Implant Sensors for Cerebral Blood Volume Monitoring.
- Ann Arbor : ProQuest Dissertations & Theses, 2018 - 96 p.
Source: Dissertations Abstracts International, Volume: 79-11, Section: B.
Thesis (Ph.D.)--Columbia University, 2018.
This item must not be sold to any third party vendors.
Nearly 50 million people are afflicted with epilepsy, worldwide. These patients suffer from unprovoked seizures, where neurons in the cerebral cortex under go uncontrolled, hypersynchronous firing of neurons. 30% of patients with epilepsy do not respond to drug treatments. For these patients, surgical treatment involving the removal or disconnection of brain matter is one of the only alternatives. Such surgical treatments often rely on long-term monitoring of neuronal activity in the brain using subdurally implanted surface electrodes to locate the epileptic focus, but these clinical methods for mapping neuronal activity suffer from low spatial resolutions and poor noise, which can limit the success of surgical treatments where an error of even 1 mm can be critical. The work described here involves the development of an implantable system for performing optical recordings of intrinsic signal (ORIS) on the surface of the brain. By taking advantage of the unique absorption spectrum of hemoglobin, cerebral blood volume (CBV) can be measured via reflectivity changes in the brain at at specific wavelengths of light. Due to the metabolic demands of the brain, the exaggerated neuronal activity and spiking associated with epileptic seizures can be detected indirectly through changes in CBV. While high resolution ORIS measurements have been recorded using externally mounted CCD sensors, this work presents some of the first developments in producing a fully implantable ORIS sensor. Progress in the development of an implantable ORIS sensor described here includes: an implantable organic light emitting diode (OLED) and organic photodetector (OPD) integrated on a highly flexible parylene-c substrate, an implantable sensor using a microLED array embedded on a flexible polyimide substrate, and the application of quantum dots to microLEDs for optical down-conversion. Successful in vivo detection of seizures is achieved with high signal-to-noise using these methods. Additionally, spatial localization of seizure activity is performed using the microLED array. These developments represent crucial first steps in the development of a full 2D neuronal mapping system using implantable ORIS devices.
ISBN: 9780355906400Subjects--Topical Terms:
649834
Electrical engineering.
Optoelectronic Neural Implant Sensors for Cerebral Blood Volume Monitoring.
LDR
:03289nmm a2200325 4500
001
2210370
005
20191121124210.5
008
201008s2018 ||||||||||||||||| ||eng d
020
$a
9780355906400
035
$a
(MiAaPQ)AAI10793983
035
$a
(MiAaPQ)columbia:14605
035
$a
AAI10793983
040
$a
MiAaPQ
$c
MiAaPQ
100
1
$a
Choi, Christopher.
$3
3437512
245
1 0
$a
Optoelectronic Neural Implant Sensors for Cerebral Blood Volume Monitoring.
260
1
$a
Ann Arbor :
$b
ProQuest Dissertations & Theses,
$c
2018
300
$a
96 p.
500
$a
Source: Dissertations Abstracts International, Volume: 79-11, Section: B.
500
$a
Publisher info.: Dissertation/Thesis.
500
$a
Advisor: Kymissis, Ioannis.
502
$a
Thesis (Ph.D.)--Columbia University, 2018.
506
$a
This item must not be sold to any third party vendors.
520
$a
Nearly 50 million people are afflicted with epilepsy, worldwide. These patients suffer from unprovoked seizures, where neurons in the cerebral cortex under go uncontrolled, hypersynchronous firing of neurons. 30% of patients with epilepsy do not respond to drug treatments. For these patients, surgical treatment involving the removal or disconnection of brain matter is one of the only alternatives. Such surgical treatments often rely on long-term monitoring of neuronal activity in the brain using subdurally implanted surface electrodes to locate the epileptic focus, but these clinical methods for mapping neuronal activity suffer from low spatial resolutions and poor noise, which can limit the success of surgical treatments where an error of even 1 mm can be critical. The work described here involves the development of an implantable system for performing optical recordings of intrinsic signal (ORIS) on the surface of the brain. By taking advantage of the unique absorption spectrum of hemoglobin, cerebral blood volume (CBV) can be measured via reflectivity changes in the brain at at specific wavelengths of light. Due to the metabolic demands of the brain, the exaggerated neuronal activity and spiking associated with epileptic seizures can be detected indirectly through changes in CBV. While high resolution ORIS measurements have been recorded using externally mounted CCD sensors, this work presents some of the first developments in producing a fully implantable ORIS sensor. Progress in the development of an implantable ORIS sensor described here includes: an implantable organic light emitting diode (OLED) and organic photodetector (OPD) integrated on a highly flexible parylene-c substrate, an implantable sensor using a microLED array embedded on a flexible polyimide substrate, and the application of quantum dots to microLEDs for optical down-conversion. Successful in vivo detection of seizures is achieved with high signal-to-noise using these methods. Additionally, spatial localization of seizure activity is performed using the microLED array. These developments represent crucial first steps in the development of a full 2D neuronal mapping system using implantable ORIS devices.
590
$a
School code: 0054.
650
4
$a
Electrical engineering.
$3
649834
650
4
$a
Medical imaging.
$3
3172799
690
$a
0544
690
$a
0574
710
2
$a
Columbia University.
$b
Electrical Engineering.
$3
1675652
773
0
$t
Dissertations Abstracts International
$g
79-11B.
790
$a
0054
791
$a
Ph.D.
792
$a
2018
793
$a
English
856
4 0
$u
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10793983
筆 0 讀者評論
館藏地:
全部
電子資源
出版年:
卷號:
館藏
1 筆 • 頁數 1 •
1
條碼號
典藏地名稱
館藏流通類別
資料類型
索書號
使用類型
借閱狀態
預約狀態
備註欄
附件
W9386919
電子資源
11.線上閱覽_V
電子書
EB
一般使用(Normal)
在架
0
1 筆 • 頁數 1 •
1
多媒體
評論
新增評論
分享你的心得
Export
取書館
處理中
...
變更密碼
登入