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Synthesis and Characterization of EG...

Qiu, Yi Mike.

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Synthesis and Characterization of EGFR-Targeted Immunoporphysomes.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Synthesis and Characterization of EGFR-Targeted Immunoporphysomes./
作者:	Qiu, Yi Mike.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2018,
面頁冊數:	68 p.
附註:	Source: Masters Abstracts International, Volume: 80-01.
Contained By:	Masters Abstracts International80-01.
標題:	Pharmaceutical sciences. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10744870
ISBN:	9780438184169

Synthesis and Characterization of EGFR-Targeted Immunoporphysomes.
Qiu, Yi Mike.

Synthesis and Characterization of EGFR-Targeted Immunoporphysomes. - Ann Arbor : ProQuest Dissertations & Theses, 2018 - 68 p.

Source: Masters Abstracts International, Volume: 80-01.

Thesis (M.Sc.)--University of Toronto (Canada), 2018.

This item must not be sold to any third party vendors.

Many nanosized drug delivery systems rely on the phenomena of enhanced permeability and retention (EPR) effect for their accumulation at the tumor site. However, recent clinical data suggest that passive accumulation of nanomedicines observed in animal models does not always translate to patients, because the tumor biology in humans is much more complex and heterogeneous. By contrast, active targeting strategies, which involve modifying the surface of nanoparticles with targeting ligands, can theoretically reduce off-target effects and increase tumor accumulation. In this study, cetuximab was conjugated to the surface of porphysomes, which is a liposome-like nanovesicle self-assembled from porphyrin lipids. This nanoparticle exhibits structurally dependent properties that enable fluorescence imaging, photothermal therapy, and photodynamic therapy applications. By functionalizing porphysomes with targeting ligands, the particles will be actively taken up by the target cells, thereby improving the efficacy of the payload.

ISBN: 9780438184169Subjects--Topical Terms:

3173021
Pharmaceutical sciences.

Synthesis and Characterization of EGFR-Targeted Immunoporphysomes.
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