東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Synthesis and Characterization of EG...

Qiu, Yi Mike.

Linked to FindBook

Google Book

Amazon

博客來

Synthesis and Characterization of EGFR-Targeted Immunoporphysomes.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Synthesis and Characterization of EGFR-Targeted Immunoporphysomes./
Author:	Qiu, Yi Mike.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2018,
Description:	68 p.
Notes:	Source: Masters Abstracts International, Volume: 80-01.
Contained By:	Masters Abstracts International80-01.
Subject:	Pharmaceutical sciences. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10744870
ISBN:	9780438184169

Synthesis and Characterization of EGFR-Targeted Immunoporphysomes.
Qiu, Yi Mike.

Synthesis and Characterization of EGFR-Targeted Immunoporphysomes. - Ann Arbor : ProQuest Dissertations & Theses, 2018 - 68 p.

Source: Masters Abstracts International, Volume: 80-01.

Thesis (M.Sc.)--University of Toronto (Canada), 2018.

This item must not be sold to any third party vendors.

Many nanosized drug delivery systems rely on the phenomena of enhanced permeability and retention (EPR) effect for their accumulation at the tumor site. However, recent clinical data suggest that passive accumulation of nanomedicines observed in animal models does not always translate to patients, because the tumor biology in humans is much more complex and heterogeneous. By contrast, active targeting strategies, which involve modifying the surface of nanoparticles with targeting ligands, can theoretically reduce off-target effects and increase tumor accumulation. In this study, cetuximab was conjugated to the surface of porphysomes, which is a liposome-like nanovesicle self-assembled from porphyrin lipids. This nanoparticle exhibits structurally dependent properties that enable fluorescence imaging, photothermal therapy, and photodynamic therapy applications. By functionalizing porphysomes with targeting ligands, the particles will be actively taken up by the target cells, thereby improving the efficacy of the payload.

ISBN: 9780438184169Subjects--Topical Terms:

3173021
Pharmaceutical sciences.

Synthesis and Characterization of EGFR-Targeted Immunoporphysomes.
LDR:02051nmm a2200313 4500 001 2210284
005 20191121124158.5
008 201008s2018 ||||||||||||||||| ||eng d
020 $a 9780438184169
035 $a (MiAaPQ)AAI10744870
035 $a (MiAaPQ)toronto:17204
035 $a AAI10744870
040 $a MiAaPQ $c MiAaPQ
100 1 $a Qiu, Yi Mike. $3 3437426
245 1 0 $a Synthesis and Characterization of EGFR-Targeted Immunoporphysomes.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2018
300 $a 68 p.
500 $a Source: Masters Abstracts International, Volume: 80-01.
500 $a Publisher info.: Dissertation/Thesis.
500 $a Advisor: Zheng, Gang.
502 $a Thesis (M.Sc.)--University of Toronto (Canada), 2018.
506 $a This item must not be sold to any third party vendors.
520 $a Many nanosized drug delivery systems rely on the phenomena of enhanced permeability and retention (EPR) effect for their accumulation at the tumor site. However, recent clinical data suggest that passive accumulation of nanomedicines observed in animal models does not always translate to patients, because the tumor biology in humans is much more complex and heterogeneous. By contrast, active targeting strategies, which involve modifying the surface of nanoparticles with targeting ligands, can theoretically reduce off-target effects and increase tumor accumulation. In this study, cetuximab was conjugated to the surface of porphysomes, which is a liposome-like nanovesicle self-assembled from porphyrin lipids. This nanoparticle exhibits structurally dependent properties that enable fluorescence imaging, photothermal therapy, and photodynamic therapy applications. By functionalizing porphysomes with targeting ligands, the particles will be actively taken up by the target cells, thereby improving the efficacy of the payload.
590 $a School code: 0779.
650 4 $a Pharmaceutical sciences. $3 3173021
690 $a 0572
710 2 $a University of Toronto (Canada). $b Pharmaceutical Sciences. $3 3170825
773 0 $t Masters Abstracts International $g 80-01.
790 $a 0779
791 $a M.Sc.
792 $a 2018
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10744870