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Using Multimodal Imaging to Examine ...

Chung, Jun Ku.

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Using Multimodal Imaging to Examine Clinical and Cognitive Correlates of Mild Cognitive Impairment and Alzheimer's Disease.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Using Multimodal Imaging to Examine Clinical and Cognitive Correlates of Mild Cognitive Impairment and Alzheimer's Disease./
作者:	Chung, Jun Ku.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2018,
面頁冊數:	326 p.
附註:	Source: Dissertations Abstracts International, Volume: 79-10, Section: B.
Contained By:	Dissertations Abstracts International79-10B.
標題:	Neurosciences. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10743789
ISBN:	9780355813807

Using Multimodal Imaging to Examine Clinical and Cognitive Correlates of Mild Cognitive Impairment and Alzheimer's Disease.
Chung, Jun Ku.

Using Multimodal Imaging to Examine Clinical and Cognitive Correlates of Mild Cognitive Impairment and Alzheimer's Disease. - Ann Arbor : ProQuest Dissertations & Theses, 2018 - 326 p.

Source: Dissertations Abstracts International, Volume: 79-10, Section: B.

Thesis (Ph.D.)--University of Toronto (Canada), 2018.

This item must not be sold to any third party vendors.

Mild cognitive impairment (MCI) may interact with depression to mediate the risk of developing Alzheimer's disease (AD). Investigating the relationship between depression-related and AD-associated pathological changes such as beta-amyloid (Aβ), tau, and hippocampal volume loss may help to explain the mechanistic links between depression and the cognitive and functional impairment underlying AD. We employed different neuroimaging techniques, including positron emission tomography (PET) and magnetic resonance imaging, to investigate several in-vivo markers of AD pathology, allowing us to examine their associations with clinical (e.g. symptoms of depression) and cognitive correlates of MCI and AD. The thesis covers five themes. The first theme seeks to explore the relationship between a lifetime history of depression and cortical Aβ burden using PET. The second theme investigates the association between late-life depressive symptoms and cortical Aβ, also using PET. The third theme examines hippocampal volume atrophy to observe how depressive symptoms and progressive hippocampal volume loss mediate the conversion process from MCI to dementia. The fourth theme focuses on the longitudinal and structural trajectories of MCI patients with suspected non-Alzheimer' disease in order to examine how their pathological and cognitive profiles differ from other MCI groups. The final theme seeks to investigate the link between usage of the psychoactive agent benzodiazepine and cerebral Aβ levels using participants' longitudinal cognitive profile and PET. Overall, a history of depression appears to be more strongly associated with increased Aβ burden than late-life depressive symptoms. However, late-life depression, in conjunction with hippocampal atrophy, may accelerate the conversion process to AD. Furthermore, this thesis emphasizes that Aβ level is not required to promote cognitive and functional deterioration; thus Aβ levels only partially explain mechanisms underlying AD pathogenesis. Lastly, this thesis elucidates the importance of early and preventative interventions to reduce the future incidence of AD.

ISBN: 9780355813807Subjects--Topical Terms:

588700
Neurosciences.

Using Multimodal Imaging to Examine Clinical and Cognitive Correlates of Mild Cognitive Impairment and Alzheimer's Disease.
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