東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Using Multimodal Imaging to Examine ...

Chung, Jun Ku.

Linked to FindBook

Google Book

Amazon

博客來

Using Multimodal Imaging to Examine Clinical and Cognitive Correlates of Mild Cognitive Impairment and Alzheimer's Disease.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Using Multimodal Imaging to Examine Clinical and Cognitive Correlates of Mild Cognitive Impairment and Alzheimer's Disease./
Author:	Chung, Jun Ku.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2018,
Description:	326 p.
Notes:	Source: Dissertations Abstracts International, Volume: 79-10, Section: B.
Contained By:	Dissertations Abstracts International79-10B.
Subject:	Neurosciences. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10743789
ISBN:	9780355813807

Using Multimodal Imaging to Examine Clinical and Cognitive Correlates of Mild Cognitive Impairment and Alzheimer's Disease.
Chung, Jun Ku.

Using Multimodal Imaging to Examine Clinical and Cognitive Correlates of Mild Cognitive Impairment and Alzheimer's Disease. - Ann Arbor : ProQuest Dissertations & Theses, 2018 - 326 p.

Source: Dissertations Abstracts International, Volume: 79-10, Section: B.

Thesis (Ph.D.)--University of Toronto (Canada), 2018.

This item must not be sold to any third party vendors.

Mild cognitive impairment (MCI) may interact with depression to mediate the risk of developing Alzheimer's disease (AD). Investigating the relationship between depression-related and AD-associated pathological changes such as beta-amyloid (Aβ), tau, and hippocampal volume loss may help to explain the mechanistic links between depression and the cognitive and functional impairment underlying AD. We employed different neuroimaging techniques, including positron emission tomography (PET) and magnetic resonance imaging, to investigate several in-vivo markers of AD pathology, allowing us to examine their associations with clinical (e.g. symptoms of depression) and cognitive correlates of MCI and AD. The thesis covers five themes. The first theme seeks to explore the relationship between a lifetime history of depression and cortical Aβ burden using PET. The second theme investigates the association between late-life depressive symptoms and cortical Aβ, also using PET. The third theme examines hippocampal volume atrophy to observe how depressive symptoms and progressive hippocampal volume loss mediate the conversion process from MCI to dementia. The fourth theme focuses on the longitudinal and structural trajectories of MCI patients with suspected non-Alzheimer' disease in order to examine how their pathological and cognitive profiles differ from other MCI groups. The final theme seeks to investigate the link between usage of the psychoactive agent benzodiazepine and cerebral Aβ levels using participants' longitudinal cognitive profile and PET. Overall, a history of depression appears to be more strongly associated with increased Aβ burden than late-life depressive symptoms. However, late-life depression, in conjunction with hippocampal atrophy, may accelerate the conversion process to AD. Furthermore, this thesis emphasizes that Aβ level is not required to promote cognitive and functional deterioration; thus Aβ levels only partially explain mechanisms underlying AD pathogenesis. Lastly, this thesis elucidates the importance of early and preventative interventions to reduce the future incidence of AD.

ISBN: 9780355813807Subjects--Topical Terms:

588700
Neurosciences.

Using Multimodal Imaging to Examine Clinical and Cognitive Correlates of Mild Cognitive Impairment and Alzheimer's Disease.
LDR:03289nmm a2200337 4500 001 2210279
005 20191121124157.5
008 201008s2018 ||||||||||||||||| ||eng d
020 $a 9780355813807
035 $a (MiAaPQ)AAI10743789
035 $a (MiAaPQ)toronto:17096
035 $a AAI10743789
040 $a MiAaPQ $c MiAaPQ
100 1 $a Chung, Jun Ku. $3 3437421
245 1 0 $a Using Multimodal Imaging to Examine Clinical and Cognitive Correlates of Mild Cognitive Impairment and Alzheimer's Disease.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2018
300 $a 326 p.
500 $a Source: Dissertations Abstracts International, Volume: 79-10, Section: B.
500 $a Publisher info.: Dissertation/Thesis.
500 $a Advisor: Graff-Guerrero, Ariel.
502 $a Thesis (Ph.D.)--University of Toronto (Canada), 2018.
506 $a This item must not be sold to any third party vendors.
520 $a Mild cognitive impairment (MCI) may interact with depression to mediate the risk of developing Alzheimer's disease (AD). Investigating the relationship between depression-related and AD-associated pathological changes such as beta-amyloid (Aβ), tau, and hippocampal volume loss may help to explain the mechanistic links between depression and the cognitive and functional impairment underlying AD. We employed different neuroimaging techniques, including positron emission tomography (PET) and magnetic resonance imaging, to investigate several in-vivo markers of AD pathology, allowing us to examine their associations with clinical (e.g. symptoms of depression) and cognitive correlates of MCI and AD. The thesis covers five themes. The first theme seeks to explore the relationship between a lifetime history of depression and cortical Aβ burden using PET. The second theme investigates the association between late-life depressive symptoms and cortical Aβ, also using PET. The third theme examines hippocampal volume atrophy to observe how depressive symptoms and progressive hippocampal volume loss mediate the conversion process from MCI to dementia. The fourth theme focuses on the longitudinal and structural trajectories of MCI patients with suspected non-Alzheimer' disease in order to examine how their pathological and cognitive profiles differ from other MCI groups. The final theme seeks to investigate the link between usage of the psychoactive agent benzodiazepine and cerebral Aβ levels using participants' longitudinal cognitive profile and PET. Overall, a history of depression appears to be more strongly associated with increased Aβ burden than late-life depressive symptoms. However, late-life depression, in conjunction with hippocampal atrophy, may accelerate the conversion process to AD. Furthermore, this thesis emphasizes that Aβ level is not required to promote cognitive and functional deterioration; thus Aβ levels only partially explain mechanisms underlying AD pathogenesis. Lastly, this thesis elucidates the importance of early and preventative interventions to reduce the future incidence of AD.
590 $a School code: 0779.
650 4 $a Neurosciences. $3 588700
650 4 $a Aging. $3 543123
650 4 $a Medical imaging. $3 3172799
690 $a 0317
690 $a 0493
690 $a 0574
710 2 $a University of Toronto (Canada). $b Medical Science. $3 3182952
773 0 $t Dissertations Abstracts International $g 79-10B.
790 $a 0779
791 $a Ph.D.
792 $a 2018
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10743789