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Whole Brain Imaging of Learning, Mem...

Vousden, Dulcie A.

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Whole Brain Imaging of Learning, Memory, and Plasticity.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Whole Brain Imaging of Learning, Memory, and Plasticity./
Author:	Vousden, Dulcie A.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2018,
Description:	232 p.
Notes:	Source: Dissertations Abstracts International, Volume: 80-02, Section: B.
Contained By:	Dissertations Abstracts International80-02B.
Subject:	Neurosciences. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10641110
ISBN:	9780438189294

Whole Brain Imaging of Learning, Memory, and Plasticity.
Vousden, Dulcie A.

Whole Brain Imaging of Learning, Memory, and Plasticity. - Ann Arbor : ProQuest Dissertations & Theses, 2018 - 232 p.

Source: Dissertations Abstracts International, Volume: 80-02, Section: B.

Thesis (Ph.D.)--University of Toronto (Canada), 2018.

This item must not be sold to any third party vendors.

Even in adulthood, experience can have a lasting impact on the brain. The processes of learning and memory formation engage disparate neural circuits and result in many structural and functional changes in the brain. This plasticity occurs at multiple scales, from changes in synaptic strength, to shifts in dendritic spine density, to cell genesis, and to mesoscopic changes in the size or shape of different brain regions. A major challenge has been visualizing this plasticity across the whole brain. Chapters 3 and 4 of this thesis present approaches to visualize neural activity, markers of synaptic plasticity, and mesoscopic structural plasticity across the entire mouse brain. These approaches are then used to investigate the behavioural requirements and cellular pathways driving a particular form of structural plasticity: changes in brain structure volume. Chapter 5 and 6 ask whether changes in brain anatomy induced by learning and experience require long-term memory formation and/or CREB-dependent transcription. Chapter 6 also characterizes the time course of these volume changes and shows that even two days of environmental enrichment can induce structural changes in the brain. Finally, chapter 7 uses hierarchical Bayesian modelling to perform a meta-analysis of several different studies of experience-dependent plasticity. This chapter shows that maze training, exercise, and environmental enrichment each have distinct and increasingly large effects on hippocampal volume. In summary, this thesis presents methods for visualizing plasticity at multiple scales and shows that MRI can be used to image subtle structural plasticity induced by learning and experience.

ISBN: 9780438189294Subjects--Topical Terms:

588700
Neurosciences.

Whole Brain Imaging of Learning, Memory, and Plasticity.
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500 $a Source: Dissertations Abstracts International, Volume: 80-02, Section: B.
500 $a Publisher info.: Dissertation/Thesis.
500 $a Advisor: Lerch, Jason P.
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